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Cited by 427

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Performance of 3-Dimensional Echocardiography in Measuring Left Ventricular Volumes and Ejection Fraction

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Dorosz, Jennifer L., Lezotte, Dennis C., Weitzenkamp, David A., Allen, Larry A., Salcedo, Ernesto E.·2012·Journal of the American College of Cardiology

Abstract

Objectives The primary aim of this systematic review is to objectively evaluate the test performance characteristics of three-dimensional echocardiography (3DE) in measuring left ventricular (LV) volumes and ejection fraction (EF). Background Despite its growing use in clinical laboratories, the accuracy of 3DE has not been studied on a large scale. It is unclear if this technology offers an advantage over traditional two-dimensional (2D) methods. Methods We searched for studies that compared LV volumes and EF measured by 3DE and cardiac magnetic resonance (CMR) imaging. A subset of those also compared standard 2D methods with CMR. We used meta-analyses to determine the overall bias and limits of agreement of LV end-diastolic volume (EDV), end-systolic volume (ESV), and EF measured by 3DE and 2D echocardiography (2DE). Results Twenty-three studies (1,638 echocardiograms) were included. The pooled biases ± 2 SDs for 3DE were −19.1 ± 34.2 ml, −10.1 ± 29.7 ml, and − 0.6 ± 11.8% for EDV, ESV, and EF, respectively. Nine studies also included data from 2DE, where the pooled biases were −48.2 ± 55.9 ml, −27.7 ± 45.7 ml, and 0.1 ± 13.9% for EDV, ESV, and EF, respectively. In this subset, the difference in bias between 3DE and 2D volumes was statistically significant (p = 0.01 for both EDV and ESV). The difference in variance was statistically significant (p < 0.001) for all 3 measurements. Conclusions Three-dimensional echocardiography underestimates volumes and has wide limits of agreement, but compared with traditional 2D methods in these carefully performed studies, 3DE is more accurate for volumes and more precise in all 3 measurements.

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Metadata

Authors
Dorosz, J. L., Lezotte, D. C., Weitzenkamp, D. A., Allen, L. A., & Salcedo, E. E.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2012-05
Volume
59
Issue
20
Pages
1799-1808
ISSN
0735-1097 (ISSN-L)
OpenAlex
W1514135335
Cited by
427
References
33
FWCI
17.07
Type
journal article
Language
en
Open access
bronze

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Dorosz, J. L., Lezotte, D. C., Weitzenkamp, D. A., Allen, L. A., & Salcedo, E. E. (2012). Performance of 3-Dimensional Echocardiography in Measuring Left Ventricular Volumes and Ejection Fraction. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2012.01.037

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