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Cited by 422

The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.

Cardiorenal Syndrome Type 1

Open access
Ronco, Claudio, Cicoira, Mariantonietta, McCullough, Peter A.·2012·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2012.01.077
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Abstract

Cardiorenal syndrome (CRS) type 1 is characterized as the development of acute kidney injury (AKI) and dysfunction in the patient with acute cardiac illness, most commonly acute decompensated heart failure (ADHF). There is evidence in the literature supporting multiple pathophysiological mechanisms operating simultaneously and sequentially to result in the clinical syndrome characterized by a rise in serum creatinine, oliguria, diuretic resistance, and in many cases, worsening of ADHF symptoms. The milieu of chronic kidney disease has associated factors including obesity, cachexia, hypertension, diabetes, proteinuria, uremic solute retention, anemia, and repeated subclinical AKI events all work to escalate individual risk of CRS in the setting of ADHF. All of these conditions have been linked to cardiac and renal fibrosis. In the hospitalized patient, hemodynamic changes leading to venous renal congestion, neurohormonal activation, hypothalamic-pituitary stress reaction, inflammation and immune cell signaling, systemic endotoxemic exposure from the gut, superimposed infection, and iatrogenesis all contribute to CRS type 1. The final common pathway of bidirectional organ injury appears to be cellular, tissue, and systemic oxidative stress that exacerbate organ function. This review explores in detail the pathophysiological pathways that put a patient at risk and then effectuate the vicious cycle now recognized as CRS type 1.

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Metadata

Authors
Ronco, C., Cicoira, M., & McCullough, P. A.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2012-09
Volume
60
Issue
12
Pages
1031-1042
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2012.01.077
OpenAlex
W106281480
Cited by
422
References
105
FWCI
22.80
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Cardiorenal Syndrome Type 1. https://app.cochat.ai/papers/10.1016/j.jacc.2012.01.077
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Ronco, C., Cicoira, M., & McCullough, P. A. (2012). Cardiorenal Syndrome Type 1. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2012.01.077

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.