Cited by 295Cardiac Valve Diseases and TreatmentsAortic Disease and Treatment ApproachesInfective Endocarditis Diagnosis and Management

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Health-Related Quality of Life After Transcatheter or Surgical Aortic Valve Replacement in High-Risk Patients With Severe Aortic Stenosis

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Reynolds, Matthew R., Magnuson, Elizabeth A., Wang, Kaijun, Thourani, Vinod H., Williams, Mathew, Zajarias, Alan, Rihal, Charanjit S., Brown, David L., Smith, Craig R., Leon, Martin B., Cohen, David J.·2012·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2012.03.075

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Abstract

Objectives This study sought to compare health status and quality-of-life outcomes for patients with severe aortic stenosis (AS) and high surgical risk treated with either transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (AVR).Background For high-risk patients with severe AS, TAVR has been shown to result in similar 12-month survival but differing adverse events compared with AVR.Methods We evaluated the health status of 628 patients with severe, symptomatic AS at high risk of surgical complications who were randomized to either TAVR or AVR in the PARTNER Trial. Health status was assessed at baseline and 1, 6, and 12 months using the Kansas City Cardiomyopathy Questionnaire, the Short Form-12, and the EuroQol-5D.Results The primary outcome, the Kansas City Cardiomyopathy Questionnaire summary score, improved more rapidly with TAVR, but was similar for the 2 groups at 6 and 12 months. However, there was a significant interaction between the benefit of TAVR and access site (transapical vs. transfemoral). Patients eligible for transfemoral TAVR demonstrated significant health status benefits with TAVR versus AVR at 1 month (difference, 9.9 points; 95% confidence interval: 4.9 to 14.9; p < 0.001), whereas patients treated via the TA approach demonstrated no benefits with TAVR compared with AVR at any time point. Results for Kansas City Cardiomyopathy Questionnaire subscales and generic measures demonstrated similar patterns.Conclusions In high-risk patients with severe AS, health status improved substantially between baseline and 1 year after either TAVR or AVR. TAVR via the transfemoral, but not the transapical route, was associated with a short-term advantage compared with surgery. (Placement of AoRTic TraNscathetER Valve [PARTNER] trial; NCT00530894).

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Authors: Reynolds, M. R., Magnuson, E. A., Wang, K., Thourani, V. H., Williams, M., Zajarias, A., Rihal, C. S., Brown, D. L., Smith, C. R., Leon, M. B., & Cohen, D. J.
Affiliations: Harvard University (US)
Saint Luke's Hospital (US)
Emory University Hospital (US)
NewYork–Presbyterian Hospital (US)
Mayo Clinic (US)
Medical City Dallas Hospital (US)
Corresponding author: Cohen, David J.
ORCID: Reynolds, Matthew R.
Magnuson, Elizabeth A.
Wang, Kaijun
Thourani, Vinod H.
Williams, Mathew
Rihal, Charanjit S.
Brown, David L.
Smith, Craig R.
Leon, Martin B.
Cohen, David J.
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2012-08
Volume: 60
Issue: 6
Pages: 548-558
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2012.03.075
OpenAlex: W49484717
Cited by: 295
References: 33
Citations by year: 2026: 5 · 2025: 11 · 2024: 14 · 2023: 15 · 2022: 14 · 2021: 16 · 2020: 15 · 2019: 19 · 2018: 23 · 2017: 22 · 2016: 37 · 2015: 26 · 2014: 24 · 2013: 39 · 2012: 15
FWCI: 21.41
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 386 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
Funders: Boston Scientific Corporation
Medtronic
Abbott Vascular
St. Jude Medical
Eli Lilly and Company
AstraZeneca
Edwards Lifesciences
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Aortic Disease and Treatment Approaches
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Infective Endocarditis Diagnosis and Management
Keywords: transcatheter aortic valve implantation, surgical aortic valve replacement, severe aortic stenosis, high surgical risk, health-related quality of life, health status, transapical approach, transfemoral access, PARTNER trial, Kansas City Cardiomyopathy Questionnaire, EuroQol-5D, SF-12
MeSH terms: Aged, 80 and over, Aortic Valve, Aortic Valve Stenosis, Female, Health Status, Heart Valve Prosthesis, Humans, Male, Quality of Life, Surveys and Questionnaires, Severity of Illness Index, Heart Valve Prosthesis Implantation

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Health-Related Quality of Life After Transcatheter or Surgical Aortic Valve Replacement in High-Risk Patients With Severe Aortic Stenosis

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