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The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Relation Between Volume of Exercise and Clinical Outcomes in Patients With Heart Failure

Open access
Keteyian, Steven J., Leifer, Eric S., Houston-Miller, Nancy, Kraus, William E., Brawner, Clinton A., O’Connor, Christopher M., Whellan, David J., Cooper, Lawton S., Fleg, Jerome L., Kitzman, Dalane W., Cohen-Solal, Alain, Blumenthal, James A., Rendall, David S., Piña, Ileana L.·2012·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2012.08.958
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Abstract

Background The HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) trial showed that among patients with heart failure (HF), regular exercise confers a modest reduction in the adjusted risk for all-cause mortality or hospitalization. Objective This study determined whether greater volumes of exercise were associated with greater reductions in clinical events. Methods Patients randomized to the exercise training arm of HF-ACTION who were event-free at 3 mo after randomization were included (n= 959). Median follow-up was 28.2 months. Clinical end points were all-cause mortality or hospitalization and cardiovascular mortality or HF hospitalization. Results A reverse J-shaped association was observed between exercise volume and adjusted clinical risk. Based on Cox regression, exercise volume was not a significant linear predictor but was a logarithmic predictor (p=0.03) for all-cause mortality or hospitalization. For cardiovascular mortality or HF hospitalization, exercise volume was a significant (p=0.001) linear and logarithmic predictor. Moderate exercise volumes of 3 to <5 and 5 to <7 MET-hr per week were associated with reductions in subsequent risk that exceeded 30%. Exercise volume was positively associated with the change in peak oxygen uptake at 3 months (r=0.10; p=0.005). Conclusions In patients with chronic systolic HF, volume of exercise is associated with the risk for clinical events, with only moderate levels (3–7 MET-hr per week) of exercise needed to observe a clinical benefit. Although further study is warranted to confirm the relationship between volume of exercise completed and clinical events, our findings support the use of regular exercise in the management of these patients. Clinical Trial Registry: http://clinicaltrials.gov/ct2/show/NCT00047437

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Metadata

Authors
Keteyian, S. J., Leifer, E. S., Houston-Miller, N., Kraus, W. E., Brawner, C. A., O’Connor, C. M., Whellan, D. J., Cooper, L. S., Fleg, J. L., Kitzman, D. W., Cohen-Solal, A., Blumenthal, J. A., Rendall, D. S., & Piña, I. L.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2012-11
Volume
60
Issue
19
Pages
1899-1905
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2012.08.958
OpenAlex
W2044220453
Cited by
204
References
7
FWCI
35.02
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Relation Between Volume of Exercise and Clinical Outcomes in Patients With Heart Failure. https://app.cochat.ai/papers/10.1016/j.jacc.2012.08.958
The paper
Keteyian, S. J., Leifer, E. S., Houston-Miller, N., Kraus, W. E., Brawner, C. A., O’Connor, C. M., Whellan, D. J., Cooper, L. S., Fleg, J. L., Kitzman, D. W., Cohen-Solal, A., Blumenthal, J. A., Rendall, D. S., & Piña, I. L. (2012). Relation Between Volume of Exercise and Clinical Outcomes in Patients With Heart Failure. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2012.08.958

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.