Cited by 266Diabetes, Cardiovascular Risks, and LipoproteinsObesity, Physical Activity, DietCardiovascular Disease and Adiposity

Healthy obese versus unhealthy lean: the obesity paradox

Lavie, Carl J., De Schutter, Alban, Milani, Richard V.·2015·Nature Reviews Endocrinology

Abstract

Overweight and obesity have reached epidemic proportions in the USA and most of the rest of the world. Particularly concerning is the very high prevalence of class III obesity (BMI ≥40 kg/m(2)), which has reached ∼3% in the USA. In the past few years, controversy has surrounded the idea that some individuals with obesity can be considered healthy with regards to their metabolic and cardiorespiratory fitness, which has been termed the 'obesity paradox'. These controversies are reviewed in detail here, including discussion of the very favourable prognosis in patients with obesity who have no notable metabolic abnormalities and who have preserved fitness. The article also discusses the suggestion that greater emphasis should be placed on improving fitness rather than weight loss per se in the primary and secondary prevention of cardiovascular diseases, at least in patients with overweight and class I obesity (BMI 30-35 kg/m(2)).

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Registry

Crossref · 10.1038/nrendo.2014.165

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82 of 82 references verified0 citation errors · 0 not checkable

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Authors
Lavie, C. J., De Schutter, A., & Milani, R. V.
Affiliations
The University of Queensland (AU)
Corresponding author
Lavie, Carl J.
Venue
Nature Reviews Endocrinology
Published
2014-09-30
Volume
11
Issue
1
Pages
55-62
ISSN
  • 1759-5029 (ISSN-L)
  • 1759-5037
OpenAlex
W2043273449
Cited by
266
References
83
Citations by year
2026: 14 · 2025: 26 · 2024: 16 · 2023: 28 · 2022: 19 · 2021: 14 · 2020: 22 · 2019: 22 · 2018: 22 · 2017: 24 · 2016: 33 · 2015: 21 · 2014: 5
FWCI
4.39
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
obesity paradox, metabolically healthy obesity, obesity, cardiovascular health, cardiorespiratory fitness, overweight, morbid obesity, cardiovascular disease prevention, weight loss, body mass index
MeSH terms
Cardiovascular Diseases, Humans, Obesity, Risk Factors, Thinness, United States, Kaplan-Meier Estimate, Physical Conditioning, Human

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