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A Randomized Trial to Assess Catheter Ablation Versus Rate Control in the Management of Persistent Atrial Fibrillation in Heart Failure
Open accessAbstract
Objectives This study sought to compare catheter ablation with rate control for persistent atrial fibrillation (AF) in heart failure (HF).Background The optimal therapy for AF in HF is unclear. Drug-based rhythm control has not proved clinically beneficial. Catheter ablation improves cardiac function in patients with HF, but impact on physiological performance has not been formally evaluated in a randomized trial.Methods In a randomized, open-label, blinded-endpoint clinical trial, adults with symptomatic HF, radionuclide left ventricular ejection fraction (EF) ≤35%, and persistent AF were assigned to undergo catheter ablation or rate control. Primary outcome was 12-month change in peak oxygen consumption. Secondary endpoints were quality of life, B-type natriuretic peptide, 6-min walk distance, and EF. Results were analyzed by intention-to-treat.Results Fifty-two patients (age 63 ± 9 years, EF 24 ± 8%) were randomized, 26 each to ablation and rate control. At 12 months, 88% of ablation patients maintained sinus rhythm (single-procedure success 68%). Under rate control, rate criteria were achieved in 96%. The primary endpoint, peak oxygen consumption, significantly increased in the ablation arm compared with rate control (difference +3.07 ml/kg/min, 95% confidence interval: 0.56 to 5.59, p = 0.018). The change was not evident at 3 months (+0.79 ml/kg/min, 95% confidence interval: -1.01 to 2.60, p = 0.38). Ablation improved Minnesota score (p = 0.019) and B-type natriuretic peptide (p = 0.045) and showed nonsignificant trends toward improved 6-min walk distance (p = 0.095) and EF (p = 0.055).Conclusions This first randomized trial of ablation versus rate control to focus on objective exercise performance in AF and HF shows significant benefit from ablation, a strategy that also improves symptoms and neurohormonal status. The effects develop over 12 months, consistent with progressive amelioration of the HF syndrome. (A Randomised Trial to Assess Catheter Ablation Versus Rate Control in the Management of Persistent Atrial Fibrillation in Chronic Heart Failure; NCT00878384).
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“For patients who develop HFrEF as a result of rapid AF (tachycardiomyopathy), a rhythm control strategy is preferred, based on several relatively small patient cohorts and trials reporting improved LV function after restoration of sinus rhythm.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [185]
In the citing paper
“Catheter ablation may be a useful method to restore LV function and quality of life in AF patients with HFrEF, 185,[226][227][228] but further data are needed.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [185]
In the citing paper
“In such patients, catheter ablation is more effective than antiarrhythmic drug therapy.185,586,713,[717][718][719][720]”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [185]
In the citing paper
“Catheter ablation of AF is effective in restoring and maintaining sinus rhythm in patients with symptomatic paroxysmal, persistent, and probably long-standing persistent AF -in general as second-line treatment after failure of or intolerance to antiarrhythmic drug therapy.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [185]
In the citing paper
“Fewer data are available reporting the effectiveness and safety of catheter ablation in patients with persistent or long-standing persistent AF, but all point to lower recurrence rates after catheter ablation compared to antiarrhythmic drug therapy with or without cardioversion.185,717,[723][724][725][726]1039”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [185]
In the citing paper
“Fewer data are available reporting the effectiveness and safety of catheter ablation in patients with persistent or long-standing persistent AF, but all point to lower recurrence rates after catheter ablation compared to antiarrhythmic drug therapy with or without cardioversion.185,717,[723][724][725][726]1039”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [185]
In the citing paper
“Several smaller trials suggest improved LV function after catheter ablation in HFrEF patients 185, 226-228, 778, 779”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [185]
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Long-term effectiveness of catheter ablation in patients with atrial fibrillation and heart failure
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“non-CA, respectively](45) and no statistically significant difference for stroke risk between treatment groups.(9,40,43,47) This is similar to results in AF patients with and without HF, in which the reduction in stroke risk after CA was not statistically significant.”
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Atrial Fibrillation Ablation in Patients with Heart Failure: One Size Does Not Fit All
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“Right ventricle insertion point 5 (5) 2 (7) 0 (0)”
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“There was a nonsignificant increase in the 6-min walk distance (6-MWD) in the ablation group but a decrease in the rate control group [12].”
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“Twenty-six RCTs that enrolled a total of 5788 patients were included in the meta-analysis.”
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“IHD, n (%), [0] 13 (17) 9 (18) 4 (15) 0.”
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“Recent randomized trials [3-5] and a 3 large meta-analysis [6] consistently reported an improvement in systolic HF symptoms and left 4 ventricular ejection function (LVEF) after AF ablation.”
BackgroundRecent advances in rhythm control for atrial fibrillation
Bond, R. C., Olshansky, B., & Kirchhof, P. F. (2017) · F1000Research · doi:10.12688/f1000research.11061.1 · Cited by 10
Vaidya, K., Arnott, C. G., Russell, A., Masson, P., Sy, R. W., & Patel, S. (2015) · Heart Lung and Circulation · doi:10.1016/j.hlc.2015.02.025 · Cited by 10
“Furthermore, various RCT employed differing definitions of CCF (Table 1), and hence patients who were recruited in some RCT [16] would have been deemed ineligible for recruitment in others [17,18].”
BackgroundInfluentialAtrial fibrillation ablation in heart failure
Balla, C., & Cappato, R. (2020) · European Heart Journal Supplements · doi:10.1093/eurheartj/suaa059 · Cited by 9
“Data from this meta-analysis indicate AF burden reduction as a possible cause of functional improvement since 22–50% of patients had AF episodes after ablation.(3,6,7,9) More recently, the Ablation vs.”
MethodA comparison of medical therapy and ablation for atrial fibrillation in patients with heart failure
Calvert, P. A. R., Farinha, J., Gupta, D., Kahn, M., Proietti, R., & Lip, G. Y. H. (2022) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2022.2050695 · Cited by 9
“In both the study by MacDonald et al. and ARC-HF [29], LVEF improved in the control arm as well as the ablation arm.”
BackgroundInfluentialMohsin, M., Zeyad, H., Khalid, H., Gapizov, A., Bibi, R., Kamani, Y. G., Rashid, A., Shams, M., Khalid, F., Khan, S., et al. (2023) · Cureus · doi:10.7759/cureus.45881 · Cited by 9
“During PVI, the goal is to create scar tissue around the pulmonary veins, interrupting the abnormal electrical pathways responsible for AF [42-44].”
BackgroundMethodInfluentialElectrophysiological Perspectives on Hybrid Ablation of Atrial Fibrillation.
Syed, F. F., & Oral, H. (2015) · PubMed Central · doi:10.4022/jafib.1290 · Cited by 9
Khan, H. R., Kralj‐Hans, I., Haldar, S., Bahrami, T. T., Clague, J. R., Souza, A. D., Francis, D. P., Hussain, W., Jarman, J. W. E., Jones, D. G., et al. (2018) · Trials · doi:10.1186/s13063-018-2487-9 · Cited by 9
Atrial fibrillation ablation in heart failure: What do we know? What can we do?
Chiocchini, A., Terricabras, M., & Verma, A. (2020) · EP Europace · doi:10.1093/europace/euaa217 · Cited by 9
Prabhu, S., Ahluwalia, N., Tyebally, S. M., Dennis, A. S., Malomo, S., Abiodun, A., Tyrlis, A., Dhillon, G. S., Segan, L. A., Graham, A. J., et al. (2021) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14923 · Cited by 9
Advanced heart failure: non-pharmacological approach
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Tereshchenko, S. N., Жиров, И. В., Uskach, T. M., Saidova, M. A., Sp, G., Rimskaya, E. M., Николаевна, Н. С., Narusov, O. Y., Safiullina, A. A., Tereshchenko, A. S., et al. (2024) · Eurasian heart journal · doi:10.38109/2225-1685-2024-2-6-76 · Cited by 8
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Atrial Fibrillation and Heart Failure With Reduced Ejection Fraction
Boehmer, A. A., Ehrlich, J. R., & Nattel, S. (2025) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2025.09.014 · Cited by 10
Atrial Fibrillation Management During Surgical vs Transcatheter Aortic Valve Replacement
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Update on Arrhythmias and Cardiac Pacing 2013
Almendral, J. M., Pombo, M., Martínez-Alday, J. D., Rebollo, J. M. G., Font, E. R., Martínez-Ferrer, J., Castellanos, E., Fernandez, F., & Ruiz‐Mateas, F. (2014) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2013.12.012 · Cited by 8
“Another report compared ablation with a strategy involving rate control for the first time in patients with persistent AF and heart failure (HF), taking peak oxygen consumption as the primary outcome measure; nevertheless, ablation proved to be superior.(11)”
MethodManagement of patients with newly-diagnosed atrial fibrillation: Insights from the BALKAN-AF survey
Kozieł, M., Simovic, S. M., Pavlović, N., Nedeljkovic, M. A., Paparisto, V., Musić, L., Goshev, E., Dan, A. R., Manola, Š., Kušljugić, Z., et al. (2019) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2019.100461 · Cited by 8
“According to guidelines, rhythm control strategy should be chosen in patients who develop HF with reduced ejection fraction, as a result of tachycardiomyopathy, to make left ventricle function better after restoration of sinus rhythm [19,38,39].”
BackgroundAtrial fibrillation in heart failure: Prime time for ablation!
Deisenhofer, I. (2021) · Heart Rhythm O2 · doi:10.1016/j.hroo.2021.10.011 · Cited by 8
Budnik, M., Gawalko, M. M., Lodziński, P., Tymińska, A., Ozierański, K., Grabowski, M., Peller, M., Wancerz, A., Kiliszek, M., Opolski, G., et al. (2022) · ESC Heart Failure · doi:10.1002/ehf2.14130 · Cited by 8
Safety and efficacy of external electrical cardioversion in patients with left ventricular leads
Lüker, J., Bodman, G. V., Sultan, A., Brömsen, J., Akbulak, R. Ö., Schäffer, B., Schreiber, D., Hoffmann, B. A., Block, M. S., Willems, S., et al. (2014) · Clinical Research in Cardiology · doi:10.1007/s00392-014-0800-5 · Cited by 8
Atrial fibrillation in heart failure: catheter and surgical interventional therapies
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“In ARC-HF, patients with symptomatic HF (an ejection fraction \35 % by radionuclide scanning) and persistent AF were randomized to catheter ablation or rate control [42].”
MethodKatsumata, Y., Tamura, Y., Kimura, T., Kohsaka, S., Sadahiro, T., Nishiyama, T., Aizawa, Y., Azuma, K., Fukuda, K., & Takatsuki, S. (2019) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14149 · Cited by 9
“It was also reported that catheter ablation (CA) in patients with persistent AF and heart failure ameliorated the objective exercise tolerance and QOL.7,8 Furthermore, maintenance of SR by CA of asymptomatic persistent AF improved exercise tolerance using treadmill test without ventilatory gas exchange measurements an…”
BackgroundPacker, M. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.013779 · Cited by 7
Effectiveness of catheter ablation of atrial fibrillation according to heart failure etiology
Black‐Maier, E., Steinberg, B. A., Trulock, K. M., Wang, F. M., Lokhnygina, Y. V., O’Neal, W. K., Al‐Khatib, S. M., Atwater, B. D., Daubert, J. P., Frazier‐Mills, C. G., et al. (2020) · Journal of Arrhythmia · doi:10.1002/joa3.12291 · Cited by 7
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“18 The absence of a known HF aetiology had the greatest odds ratio of association with response in the multivariable regression model in the ANTWOORD study (OR 33.5; 95% CI [6.0–187.4]; p<0.001).”
InfluentialChandan, N., Ashok, V., Hwang, T., Lim, V. G., Lachlan, T., Eftekhari, H., McGregor, G., & Osman, F. (2025) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm27175 · Cited by 7
“Similarly, the ARC-HF trial [84] found that catheter ablation led to significant improvements in exercise capacity, quality of life, and the neurohormonal states of patients compared to a pharmacological rate control strategy.”
Catheter ablation and mortality, stroke and heart failure readmission with atrial fibrillation
Pallisgaard, J. L., Hansen, M. L., Schjerning, A.-M., Johannessen, A. C., Gerds, T. A., Gustafsson, F., Gislason, G., Torp-Pedersen, C., Jacobsen, P. K., Kristensen, S. L., et al. (2020) · Open Heart · doi:10.1136/openhrt-2020-001369 · Cited by 7
The Year in Review of Clinical Cardiac Electrophysiology
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Atrial Fibrillation in Heart Failure—Diagnostic, Therapeutic, and Prognostic Relevance
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Aoyama, D., Miyazaki, S., Hasegawa, K., Nagao, M., Kakehashi, S., Mukai, M., Sekihara, T., Nodera, M., Eguchi, T., Aiki, T., et al. (2021) · Heart and Vessels · doi:10.1007/s00380-021-01829-8 · Cited by 8
Koniari, I. C., Artopoulou, E., Velissaris, D., Kounis, N. G., & Tsigkas, G. (2021) · PubMed Central · doi:10.11909/j.issn.1671-5411.2021.05.003 · Cited by 8
Lee, W., Fang, H., Wu, P., Chen, H., Fang, Y., & Chen, M. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1165011 · Cited by 7
“The enrollment criterion for HF trial patients in four studies was LVEF≤ 35% (5, 6, 9, 11).”
BackgroundMethodJones, D. G., Haldar, S., Donovan, J., McDonagh, T. A., Sharma, R. K., Hussain, W., Markides, V., & Wong, T. (2016) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12919 · Cited by 7
An, Y., Esato, M., Ishii, M., Iguchi, M., Masunaga, N., Tsuji, H., Wada, H., Hasegawa, K., Ogawa, H., Abe, M., et al. (2018) · Heart and Vessels · doi:10.1007/s00380-018-1194-5 · Cited by 7
“Several studies have shown that rhythmcontrol therapy by CA in patients with sustained AF resulted in improved left ventricular function, functional capacity assessed by cardiopulmonary exercise testing, and quality of life compared with rate-control therapy [6, 7].”
BackgroundThe impact of catheter ablation for atrial fibrillation in heart failure
Moschonas, K., Nabeebaccus, A., Okonko, D. O., McDonagh, T. A., MURGATROYD, F. D., Dhillon, P., & Scott, P. A. (2018) · Journal of Arrhythmia · doi:10.1002/joa3.12115 · Cited by 7
“Of the remaining seven studies, four reported mortality data(6,7,11,13), six hospitalization data(7-9,11-13), seven data on change in LVEF(6-9,11-13), five data on change in MLWHF score(6-9,13), six data on change in 6‐minute walk test,(7-9,11-13) and two data on change in VO2 max.(6,7)”
Rhythm Control in Patients with Heart Failure with Preserved Ejection Fraction: A Meta-Analysis
Prasitlumkum, N., Chokesuwattanaskul, R., Cheungpasitporn, W., Kewcharoen, J., Thongprayoon, C., Bathini, T. J., Vallabhajosyula, S., & Jongnarangsin, K. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10184038 · Cited by 7
Vrachatis, D. A., Deftereos, S. G., Kekeris, V., Tsoukala, S., & Γιαννόπουλος, Γ. (2018) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2018.41.2 · Cited by 7
“In the Assess Catheter Ablation Versus Rate Control in the Management of Persistent Atrial Fibrillation in Chronic Heart Failure (ARC-AF trial) LVEF improved significantly in both the CA and rate control groups, but the magnitude of change was comparable between groups.(29) The Catheter Ablation Versus Medical Treatme…”
ResultHaldar, S., Jones, D. G., Khan, H. R., Panikker, S., Jarman, J. W. E., Butcher, C., Lim, E. K. S., Wynn, G. J., Gupta, D., Hussain, W., et al. (2017) · EP Europace · doi:10.1093/europace/euw380 · Cited by 6
Atrial Fibrillation in Patients with Heart Failure: Current State and Future Directions
Mene-Afejuku, T. O., Lopez, P. D., Akinlonu, A. A., Dumancas, C. Y., Visco, F., Mushiyev, S., & Pekler, G. (2018) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-018-0276-1 · Cited by 6
Zhu, S., Zheng, M., Yan, R., Tan, Z., Zhao, H., Zhang, J., & Peng, J. (2020) · PubMed Central · doi:10.12122/j.issn.1673-4254.2020.10.06 · Cited by 6
“[29]Jones DG, Haldar SK, Hussain W, et al.”
BackgroundEsato, M., An, Y., Ogawa, H., Wada, H., Hasegawa, K., Tsuji, H., Abe, M., & Akao, M. (2021) · Heart and Vessels · doi:10.1007/s00380-021-01796-0 · Cited by 6
Song, J., Zhang, Q., Ye, L., Zheng, Y., & Wang, L. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262702 · Cited by 6
Yu, L., Jiang, R., Sun, Y., Ye, Y., Zhang, P., Liu, Q., Sheng, X., Zhang, Z., Chen, S., Fu, G., et al. (2022) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.14507 · Cited by 6
Yu, Z., Xing, Y., Peng, J., Xu, B., Qi, Y., Zheng, Z., Qiu, Y., Qiu, F., & Peng, F. (2022) · The Anatolian Journal of Cardiology · doi:10.5152/anatoljcardiol.2022.1826 · Cited by 6
Catheter Ablation for Atrial Fibrillation in Structural Heart Disease: A Review
Brasca, F. M. A., Menè, R., & Perego, G. B. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041431 · Cited by 6
Kantharia, B. K. (2023) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.16021 · Cited by 6
Ablation versus medical therapy for patients with atrial fibrillation: An updated meta‐analysis
Kheshti, F., Abdollahifard, S., Hosseinpour, A., Bazrafshan, M., & Attar, A. (2023) · Clinical Cardiology · doi:10.1002/clc.24184 · Cited by 5
“5,8,10,37 The comparator medical therapy group in most of the selected studies used AADs, while four trials used the rate control medications, 29,30,32,35 and three trials used a combination of both.”
MethodWang, M., Cai, S., Ding, W. J., Deng, Y., & Zhao, Q. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174510 · Cited by 6
Malik, A. H., & Aronow, W. S. (2018) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000000892 · Cited by 6
Impact of exercise capacity on the long-term incidence of atrial arrhythmias in heart failure
Sakai, T., Yagishita, A., Morise, M., Sakama, S., Ijichi, T., Ayabe, K., Amino, M., Ikari, Y., & Yoshioka, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-98172-9 · Cited by 5
Younes, H., Noujaim, C., Mekhael, M., Chouman, N., Assaf, A. Y. M., Kreidieh, O., Lim, C., Marrouche, N. F., & Donnellan, E. (2023) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2023.2172402 · Cited by 6
“AF-free survival in the ablation arm was significantly higher (84% off AAD); and there were significant improvements in QOL and BNP; in addition to a non-significant increase in LVEF and 6 minute walking distance [39].”
Fibrilación auricular: enfoque para el médico no cardiólogo
de Caldas, U., Forero, J., Moreno, J., del Bosque, U., Agudelo, C. A., Cayre, I. P. S., Rodríguez, E., de Manizales, I. D. C., & Sánchez, P. (2017) · IATREIA · doi:10.17533/udea.iatreia.v30n4a05 · Cited by 7
“Un estudio comparando control de respuesta ventricular estricto contra control de ritmo por ablación con catéter en este grupo de pacientes, demostró mejoría de calidad de vida y niveles de BNP (60); lo cual está respaldado por un metaanálisis reciente de esta estrategia de manejo en pacientes con falla cardiaca, con…”
BackgroundTackling Patient-Reported Outcomes in Atrial Fibrillation and Heart Failure
Steinberg, B. A., & Piccini, J. P. (2019) · Cardiology Clinics · doi:10.1016/j.ccl.2019.01.013 · Cited by 7
Packer, M. (2019) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.119.007222 · Cited by 6
Yang, E., & Rashid, H. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1349584 · Cited by 5
Yanagisawa, S., Inden, Y., Fujii, A., Sakamoto, Y., Tomomatsu, T., Mamiya, K., Okamoto, H., Murohara, T., & Shibata, R. (2020) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12807 · Cited by 5
“…quality of life with better maintenance of sinus rhythm as compared to the former approaches in previous reports (Fiala et al., 2014; Haissaguerre et al., 2005; Jones et al., 2013; Katayama et al., 2019; Katsumata et al., 2019; Mohanty et al., 2014; Ueshima et al., 1993; Yagishita et al., 2017).”
ResultMboweni, N., Maseko, M. J., & Tsabedze, N. (2023) · ESC Heart Failure · doi:10.1002/ehf2.14332 · Cited by 5
Bordi, L.-L., Opincariu, D., Benedek, T., Kovács, I., Parajkó, Z., Márton, E., Gerculy, R., & Benedek, I. (2023) · Journal of Cardiovascular Emergencies · doi:10.2478/jce-2023-0004 · Cited by 5
Bai, L., Sun, Y., Si, J., Ding, Z., Zhang, X., Zhang, Y., Xia, Y., & Liu, Y. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1265269 · Cited by 5
Rhythm Control of Atrial Fibrillation in Heart Failure with Reduced Ejection Fraction
Burkman, G. M., & Naccarelli, G. V. (2020) · Current Cardiology Reports · doi:10.1007/s11886-020-01336-8 · Cited by 5
Boyalla, V., Jarman, J. W. E., Markides, V., Hussain, W., Wong, T., Mead, R. H., Engel, G., Kong, M. H., Patrawala, R. A., & Winkle, R. A. (2021) · Open Heart · doi:10.1136/openhrt-2021-001653 · Cited by 5
“Such a score may help to better advise individual patients about the effectiveness of catheter ablation for non-PAF.”
Ribeiro, J. M., Sousa, P. A., António, N., Baptista, R., Elvas, L., Barra, S., & Gonçalves, L. M. M. (2021) · Revista Portuguesa de Cardiologia · doi:10.1016/j.repc.2020.08.014 · Cited by 5
SCHWARTZMAN, D. S., Housel, D., Bazaz, R. R., Jain, S. K., Saba, S., Gorcsan, J., & ADELSTEIN, E. C. (2014) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12535 · Cited by 5
Cardiac Resynchronization Therapy Update: Evolving Indications, Expanding Benefit?
Butcher, C., Mareev, Y. V., Markides, V., Mason, M. J., Wong, T., & Cleland, J. G. F. (2015) · Current Cardiology Reports · doi:10.1007/s11886-015-0641-5 · Cited by 5
Sciarra, L., Iacopino, S., Arena, G., Tondo, C., Pieragnoli, P., Molon, G., Manfrin, M., Curnis, A., Russo, A. D., Rovaris, G., et al. (2021) · Cardiology Research and Practice · doi:10.1155/2021/9996047 · Cited by 5
Catheter ablation for non-paroxysmal atrial fibrillation. A review
Hassouna, S., & Osmancik, P. P. (2024) · Biomedical Papers · doi:10.5507/bp.2023.053 · Cited by 4
Nor, M. A., Bolaji, O., Bilal, A., Mahmoud, M., Wardhere, A., Kelley, J., & Assal, C. (2025) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.70017 · Cited by 4
“…Catheter Ablation Versus Rate Control in the Management of Persistent Atrial Fibrillation in Heart Failure) demonstrated improvements in peak oxygen consumption, sinus rhythm maintenance, quality of life scores, and left ventricular ejection fraction (LVEF) with CA compared to rate control [13].”
2018 Korean Guidelines for Catheter Ablation of Atrial Fibrillation: Part I
Park, H., Jeong, D. S., Yu, H. T., Pak, H., Uhm, J., Kim, J. Y., Kim, J., Lee, J., Kim, K. H., Roh, S., et al. (2018) · International Journal of Arrhythmia · doi:10.18501/arrhythmia.2018.011 · Cited by 4
Kozieł, M., Mihajlovic, M., Nedeljkovic, M. A., Pavlović, N., Paparisto, V., Musić, L., Trendafilova, E., Dan, A. R., Kušljugić, Z., Dan, G., et al. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14080 · Cited by 4
“According to guidelines, a rhythm control strategy should be used in patients who develop HF with reduced ejection fraction, as a result of tachycardiomyopathy, to make left ventricle function better after restoration of sinus rhythm [2, 40, 41].”
MethodBoriani, G., Vitolo, M., & Imberti, J. F. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2642 · Cited by 4
Kato, S., Azuma, M., Kodama, S., Horita, N., & Utsunomiya, D. (2024) · ESC Heart Failure · doi:10.1002/ehf2.14919 · Cited by 4
Metadata
- Authors
- Jones, D. G., Haldar, S. K., Hussain, W., Sharma, R., Francis, D. P., Rahman-Haley, S. L., McDonagh, T. A., Underwood, S. R., Markides, V., & Wong, T.
- Affiliations
- National Health Service (GB)
- Corresponding author
- Wong, Tom
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 61
- Issue
- 18
- Pages
- 1894-1903
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2159999579
- Cited by
- 481
- References
- 44
- Citations by year
- 2026: 16 · 2025: 20 · 2024: 41 · 2023: 36 · 2022: 59 · 2021: 45 · 2020: 41 · 2019: 43 · 2018: 49 · 2017: 37 · 2016: 31 · 2015: 23 · 2014: 26 · 2013: 12
- FWCI
- 20.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- St. Jude Medical
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- persistent atrial fibrillation, heart failure, catheter ablation, rate control, peak oxygen uptake, exercise capacity, left ventricular ejection fraction, brain natriuretic peptide, quality of life, 6-minute walk distance, sinus rhythm maintenance, cardiac rehabilitation, heart failure with reduced ejection fraction, heart failure with preserved ejection fraction
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Atrial Fibrillation, Double-Blind Method, Electrocardiography, Female, Follow-Up Studies, Heart Conduction System, Heart Failure, Heart Rate, Humans, Male, Middle Aged, Prospective Studies, Quality of Life, Ventricular Function, Left, Treatment Outcome, Catheter Ablation, Young Adult
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