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Lipoprotein(a) Levels in Familial Hypercholesterolemia
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“Some studies of individuals with Familial Hypercholesterolemia (FH) have reported an increase in Lp(a) levels40-42, but others have not43-45 and suggested that the former may have been confounded by diagnostic ascertainment bias and/or unequal distributions of LPA risk alleles between FH and non-FH populations44,45.”
From Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening (2025) · cites this paper as [41]
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Research works printed but not linked: 25
- Slack, 1969, Risks of ischaemic heart-disease in familial hyperlipoproteinaemic states, Lancet, 2, 1380, 10.1016/S0140-6736(69)90930-1 · DOI
- Alonso, 2002, Heterozygous familial hypercholesterolemia in Spain. Description of 819 non related cases, Med Clin (Barc), 118, 487, 10.1016/S0025-7753(02)72428-7 · DOI
- 1991, The risk of fatal coronary heart disease in familial hypercholesterolemia, BMJ, 3030, 893
- Jansen, 2004, The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients, J Intern Med, 256, 482, 10.1111/j.1365-2796.2004.01405.x · DOI
- Nordestgaard, 2010, European Atherosclerosis Society Consensus Panel. Lipoprotein(a) as a cardiovascular risk factor: current status, Eur Heart J, 31, 2844, 10.1093/eurheartj/ehq386 · DOI · Paper page
- Erqou, 2009, Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality, JAMA, 302, 412, 10.1001/jama.2009.1063 · DOI · Paper page
- Kamstrup, 2008, Extreme lipoprotein(a) levels and risk of myocardial infarction in the general population: the Copenhagen City Heart Study, Circulation, 117, 176, 10.1161/CIRCULATIONAHA.107.715698 · DOI
- Seed, 1990, Relation of serum lipoprotein(a) concentration and apolipoprotein(a) phenotype to coronary heart disease in patients with familial hypercholesterolemia, N Engl J Med, 322, 1494, 10.1056/NEJM199005243222104 · DOI
- de Sauvage Nolting, 2003, Prevalence and significance of cardiovascular risk factors in a large cohort of patients with familial hypercholesterolaemia, J Intern Med, 253, 161, 10.1046/j.1365-2796.2003.01070.x · DOI
- Hopkins, 2001, Evaluation of coronary risk factors in patients with heterozygous familial hypercholesterolemia, Am J Cardiol, 87, 547, 10.1016/S0002-9149(00)01429-6 · DOI
- Holmes, 2005, Lipoprotein(a) is an independent risk factor for cardiovascular disease in heterozygous familial hypercholesterolemia, Clin Chem, 51, 2067, 10.1373/clinchem.2005.055228 · DOI
- Nenseter, 2011, Lipoprotein(a) levels in coronary heart disease-susceptible and -resistant patients with familial hypercholesterolemia, Atherosclerosis, 216, 426, 10.1016/j.atherosclerosis.2011.02.007 · DOI
- Mata, 2011, Clinical characteristics and evaluation of LDL-cholesterol treatment of the Spanish Familial Hypercholesterolemia Longitudinal Cohort Study (SAFEHEART), Lipids Health Dis, 10, 94, 10.1186/1476-511X-10-94 · DOI
- Alonso, 2009, Genetic diagnosis of familial hypercholesterolemia using a DNA-array based platform, Clin Biochem, 42, 899, 10.1016/j.clinbiochem.2009.01.017 · DOI
- Simó, 2003, Evaluation of a fully-automated particle-enhanced turbidimetric immunoassay for the measurement of plasma lipoprotein(a). Population-based reference values in an area with low incidence of cardiovascular disease, Clin Biochem, 36, 129, 10.1016/S0009-9120(02)00416-2 · DOI
- Alonso, 2008, Cardiovascular disease in familial hypercholesterolaemia: influence of low-density lipoprotein receptor mutation type and classic risk factors, Atherosclerosis, 200, 315, 10.1016/j.atherosclerosis.2007.12.024 · DOI
- Wiklund, 1990, Apolipoprotein(a) and ischaemic heart disease in familial hypercholesterolemia, Lancet, 335, 1360, 10.1016/0140-6736(90)91242-3 · DOI
- Utermann, 1989, Defects in the low density lipoprotein receptor gene affect lipoprotein(a) levels: multiplicative interaction of two loci associated with premature atherosclerosis, Proc Natl Acad Sci U S A, 86, 4171, 10.1073/pnas.86.11.4171 · DOI
- Lingenhel, 1998, Concentrations of the atherogenic Lp(a)are elevated in FH, Eur J Hum Genet, 6, 50, 10.1038/sj.ejhg.5200152 · DOI · Paper page
- Mbewu, 1991, Serum Lipoprotein(a) in patients heterozygous for familial hypercholesterolemia, their relatives and unrelated control populations, Arterioscler Thromb, 11, 940, 10.1161/01.ATV.11.4.940 · DOI
- Leitersdorf, 1991, Diverse effect of ethnicity on plasma lipoprotein (a) levels in heterozygous patients with familial hypercholesterolemia, J Lipid Res, 32, 1513, 10.1016/S0022-2275(20)41918-2 · DOI
- Kraft, 2000, Lipoprotein(a) in homozygous familial hypercholesterolemia, Arterioscler Thromb Vasc Biol, 20, 522, 10.1161/01.ATV.20.2.522 · DOI · Paper page
- Thompson, 2008, Recommendations for the use of LDL apheresis, Atherosclerosis, 198, 247, 10.1016/j.atherosclerosis.2008.02.009 · DOI
- Alonso, 2013, Early diagnosis and treatment of familial hypercholesterolemia: improving patient outcomes, Expert Rev Cardiovasc Ther, 11, 327, 10.1586/erc.13.7 · DOI
- Tsimikas, 2012, Lipoprotein(a) as a potential causal genetic risk factor of cardiovascular disease: a rationale for increased efforts to understand its pathophysiology and develop targeted therapies, J Am Coll Cardiol, 60, 716, 10.1016/j.jacc.2012.04.038 · DOI
Cited by
Sorted by citations
Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening
Khan, T. G., Bragazzi Cunha, J., Raut, C., Burroughs, M., Vyas, H. S., Leix, K., Goonewardena, S. N., Smrcka, A. V., Speliotes, E. K., & Emmer, B. T. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119174 · Cited by 6
Metadata
- Authors
- Alonso, R., Andres, E., Mata, N., Fuentes-Jiménez, F., Badimón, L., López-Miranda, J., Padró, T., Muñiz, O., Díaz-Díaz, J. L., Mauri, M., Ordovás, J. M., & Mata, P.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 63
- Issue
- 19
- Pages
- 1982-1989
- ISSN
- 0735-1097
- Cited by
- 323
- References
- 0
- Language
- en
- Licence
- Funders
- Familial Hypercholesterolemia Foundation (G03/101)
- Instituto de Salud Carlos III (FIS PI12/01289)
- Centro Nacional de Investigación Cardiovascular (08-2008)
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