The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
The Prevalence, Incidence, Progression, and Risks of Aortic Valve Sclerosis
Open accessAbstract
Objectives The aim of this study was to comprehensively review the epidemiology of aortic sclerosis (ASc) and its association with cardiovascular events.Background ASc, which is defined as thickening or calcification of the aortic valve without significant obstruction of blood flow, is a common finding on cardiac imaging.Methods We searched MEDLINE and EMBASE from inception to April 2013 for studies describing the epidemiology of ASc and performed a meta-analysis of the risk of adverse events using a random effects model.Results Twenty-two studies were identified from the systematic review. The prevalence of ASc increased in proportion to the average age of study participants, ranging from 9% in a study in which the mean age was 54 years to 42% in a study in which the mean age was 81 years. In total, 1.8% to 1.9% of participants with ASc had progression to clinical aortic stenosis per year. There was a 68% increased risk of coronary events in subjects with ASc (hazard ratio [HR]: 1.68; 95% confidence interval [CI]: 1.31 to 2.15), a 27% increased risk of stroke (HR: 1.27; 95% CI: 1.01 to 1.60), a 69% increased risk of cardiovascular mortality (HR: 1.69; 95% CI: 1.32 to 2.15), and a 36% increased risk of all-cause mortality (HR: 1.36; 95% CI: 1.17 to 1.59).Conclusions ASc is a common finding that is more prevalent with older age. Despite low rates of progression to ASc, there is an independent increase in morbidity and mortality associated with the condition.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“According to a recent meta-analysis, the rate of progression to AS in individuals with aortic sclerosis is 1.8–1.9% of patients per year11.”
From Calcific aortic stenosis (2016) · cites this paper as [11]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Therefore, when lifespan or quality of life is profoundly limited by frailty, noncardiac disease, mental or physical disability, the potential benefit of AVR may be low11.”
From Calcific aortic stenosis (2016) · cites this paper as [11]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
Clinical Factors Associated With Calcific Aortic Valve Disease
Stewart, B. F., Siscovick, D., Lind, B. K., Gardin, J. M., Gottdiener, J. S., Smith, V. E., Kitzman, D. W., & Otto, C. M. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00563-3 · Cited by 2,029
Intensive Lipid Lowering with Simvastatin and Ezetimibe in Aortic Stenosis
Rossebø, A. B., Pedersen, T. R., Boman, K., Brudi, P., Chambers, J. B., Egstrup, K., Gerdts, E., Gohlke-Bärwolf, C., Holme, I., Kesäniemi, Y. A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0804602 · Cited by 1,644
Association of Aortic-Valve Sclerosis with Cardiovascular Mortality and Morbidity in the Elderly
Otto, C. M., Lind, B. K., Kitzman, D. W., Gersh, B. J., & Siscovick, D. S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907153410302 · Cited by 1,281
Lindroos, M., Kupari, M. M., Heikkilä, J., & Tilvis, R. S. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90249-z · Cited by 1,148
A Randomized Trial of Intensive Lipid-Lowering Therapy in Calcific Aortic Stenosis
Cowell, S. J., Newby, D. E., Prescott, R. J., Bloomfield, P., Reid, J., Northridge, D. B., & Boon, N. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043876 · Cited by 1,146
Chan, K. L., Teo, K., Dumesnil, J. G., Ni, A., & Tam, J. (2010) · Circulation · doi:10.1161/circulationaha.109.900027 · Cited by 815
Mild and moderate aortic stenosis Natural history and risk stratification by echocardiography
Rosenhek, R. (2004) · European Heart Journal · doi:10.1016/j.ehj.2003.12.002 · Cited by 461
Cueff, C., Serfaty, J.-M., Cimadevilla, C., Laissy, J.-P., Himbert, D., Tubach, F., Duval, X., Iung, B., Enriquez-Sarano, M., Vahanian, A., et al. (2011) · Heart · doi:10.1136/hrt.2010.198853 · Cited by 385
Messika–Zeitoun, D., Aubry, M.-C., Détaint, D., Bielak, L. F., Peyser, P. A., Sheedy, P. F., Turner, S. T., Breen, J. F., Scott, C. G., Tajik, A. J., et al. (2004) · Circulation · doi:10.1161/01.cir.0000135469.82545.d0 · Cited by 383
Research works printed but not linked: 2
- Kaelsch, 2011, Prevalence of aortic and mitral valvular calcification as a marker of atherosclerosis for improved cardiovascular risk prediction assessed by computed tomography, Eur Heart J, 32, 222
- Lowery, 2012, Prevalence of previously undiagnosed aortic and mitral valve disease in a community population over the age of 60, Eur Heart J Cardiovasc Imaging, 13, i18
Cited by
Sorted by citations
Lindman, B. R., Clavel, M.-A., Mathieu, P., Iung, B., Lancellotti, P., Otto, C. M., & Pibarot, P. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.6 · Cited by 982
Global epidemiology of valvular heart disease
Coffey, S., Roberts-Thomson, R., Brown, A. D. H., Carapetis, J. R., Chen, M., Enriquez-Sarano, M. L., Zuhlke, L. J., & Prendergast, B. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00570-z · Cited by 791
Self-citationd'Arcy, J. L., Coffey, S., Loudon, M. A., Kennedy, A., Pearson-Stuttard, J., Birks, J., Frangou, E., Farmer, A. J., Mant, D., Wilson, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw229 · Cited by 724
Self-citationPrevalence and Outcomes of Concomitant Aortic Stenosis and Cardiac Amyloidosis
Nitsche, C., Scully, P. R., Patel, K., Kammerlander, A. A., Koschutnik, M., Donà, C., Wollenweber, T., Ahmed, N. A., Thornton, G. D., Kelion, A. D., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.11.006 · Cited by 390
The modern epidemiology of heart valve disease
Coffey, S., Cairns, B. J., & Iung, B. (2015) · Heart · doi:10.1136/heartjnl-2014-307020 · Cited by 326
Self-citationCalcific aortic valve disease: from molecular and cellular mechanisms to medical therapy
Kraler, S., Blaser, M. C., Aikawa, E., Camici, G. G., & Lüscher, T. F. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehab757 · Cited by 281
Imaging and Impact of Myocardial Fibrosis in Aortic Stenosis
Bing, R., Cavalcante, J. L., Everett, R. J., Clavel, M.-A. A., Newby, D. E., & Dweck, M. R. (2019) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2018.11.026 · Cited by 278
Smith, J. G., Luk, K., Schulz, C.-A., Engert, J. C., Do, R., Hindy, G., Rukh, G., Dufresne, L., Almgren, P., Owens, D. S., et al. (2014) · JAMA · doi:10.1001/jama.2014.13959 · Cited by 238
Zhong, G., Su, S., Li, J., Zhao, H., Hu, D., Chen, J., Li, S., Lin, Y., Wen, L., Lin, X., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg0478 · Cited by 127
Role of oxidative stress in calcific aortic valve disease and its therapeutic implications
Greenberg, H. Z. E., Zhao, G., Shah, A. M., & Zhang, M. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab142 · Cited by 115
Evaluating Medical Therapy for Calcific Aortic Stenosis
Lindman, B. R., Sukul, D., Dweck, M. R., Madhavan, M. V., Arsenault, B. J., Coylewright, M. J., Merryman, W. D., Newby, D. E., Lewis, J., Harrell, F. E., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.09.1367 · Cited by 115
Limited versus full sternotomy for aortic valve replacement
Kirmani, B. H., Jones, S., Malaisrie, S. C., Chung, D. A., & Williams, R. J. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011793.pub2 · Cited by 98
Calcific Aortic Stenosis: A Review
Otto, C. M., Newby, D. E., & Hillis, G. S. (2024) · JAMA · doi:10.1001/jama.2024.16477 · Cited by 97
Development of calcific aortic valve disease: Do we know enough for new clinical trials?
Kostyunin, A. E., Yuzhalin, A. E., Ovcharenko, E. A., & Kutikhin, A. G. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.05.016 · Cited by 102
Adaptive immune cells in calcific aortic valve disease
Raddatz, M. A., Madhur, M. S., & Merryman, W. D. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00100.2019 · Cited by 97
Biomarkers of Calcific Aortic Valve Disease
Small, A., Kiss, D., Giri, J. S., Anwaruddin, S., Siddiqi, H. K., Guerraty, M. A., Chirinos, J. A., Ferrari, G. M., & Rader, D. J. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308615 · Cited by 98
Ring, L. S., Shah, B. N., Bhattacharyya, S., Harkness, A., Belham, M., Oxborough, D., Pearce, K., Rana, B. S., Augustine, D. X., Robinson, S., et al. (2021) · Echo Research and Practice · doi:10.1530/erp-20-0035 · Cited by 76
Small, A., Yutzey, K. E., Binstadt, B. A., Key, K. V., Bouatia‐Naji, N., Milan, D., Aïkawa, E., Otto, C. M., & Hilaire, C. S. (2024) · Circulation · doi:10.1161/cir.0000000000001254 · Cited by 82
Faggiano, P. M., Dasseni, N., Gaibazzi, N., Rossi, A., Henein, M. Y., & Pressman, G. S. (2019) · European Journal of Preventive Cardiology · doi:10.1177/2047487319830485 · Cited by 68
Risk factors for valvular calcification
Chen, H. Y., Engert, J. C., & Thanassoulis, G. (2019) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000471 · Cited by 66
Epidemiology of Valvular Heart Disease
Peters, A. S., Duggan, J. P., Trachiotis, G. D., & Antevil, J. L. (2022) · Surgical Clinics of North America · doi:10.1016/j.suc.2022.01.008 · Cited by 69
Li, J., Zeng, Q., Xiong, Z., Xian, G., Liu, Z., Zhan, Q., Lai, W., Ao, L., Meng, X., Ren, H., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab243 · Cited by 52
Zheng, D., Zang, Y., Xu, H., Wang, Y., Cao, X., Wang, T., Pan, M., Shi, J., & Li, X. (2018) · Clinical Research in Cardiology · doi:10.1007/s00392-018-1398-9 · Cited by 51
Dissecting Calcific Aortic Valve Disease—The Role, Etiology, and Drivers of Valvular Fibrosis
Buttner, P. G., Feistner, L., Lurz, P. C., Thiele, H., Hutcheson, J. D., & Schlotter, F. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.660797 · Cited by 46
Genome-wide association studies of late-onset cardiovascular disease
Smith, J. G., & Newton‐Cheh, C. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.04.004 · Cited by 51
Lipoprotein(a): Emerging insights and therapeutics
Kaur, G., Abdelrahman, K., Berman, A. N., Biery, D. W., Shiyovich, A., Huck, D. M., Garshick, M. S., Blankstein, R., & Weber, B. (2024) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2024.100641 · Cited by 49
Minno, M. N. D. D., Minno, A. D., Ambrosino, P., Songia, P., Pepi, M., Tremoli, E., & Poggio, P. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.01.054 · Cited by 45
Pasipoularides, A. D. (2016) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-016-9679-z · Cited by 47
Calcification and extracellular matrix dysregulation in human postmortem and surgical aortic valves
Gomez‐Stallons, M. V., Tretter, J. T., Hassel, K. R., Gonzalez-Ramos, O., AMOFA, D., Ollberding, N. J., Mazur, W. M., Choo, J. K., Smith, J. M., Kereiakes, D. J., et al. (2019) · Heart · doi:10.1136/heartjnl-2019-314879 · Cited by 44
Added benefits of early detection of other diseases on low-dose CT screening
for the I-ELCAP Investigators, Yip, R., Jirapatnakul, A. C., Hu, M., Chen, X., Han, D., Ma, T., Zhu, Y., Salvatore, M. M., Margolies, L. R., et al. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-20-746 · Cited by 42
Vignale, D., Palmisano, A., Gnasso, C., Margonato, D., Romagnolo, D., Barbieri, S., Ingallina, G., Stella, S., Ancona, M. B., Montorfano, M., et al. (2023) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jead040 · Cited by 41
Valvular heart disease in patients with cardiac amyloidosis
Aimo, A., Camerini, L., Fabiani, I., Morfino, P., Panichella, G., Barison, A., Pucci, A., Castiglione, V., Vergaro, G., Sinagra, G., et al. (2023) · Heart Failure Reviews · doi:10.1007/s10741-023-10350-1 · Cited by 40
Fiber Scaffold Patterning for Mending Hearts: 3D Organization Bringing the Next Step
Kristen, M., Ainsworth, M. J., Chirico, N., van der Ven, C. F. T., Doevendans, P. A., Sluijter, J. P. G., Malda, J., van Mil, A., & Castilho, M. D. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900775 · Cited by 40
Coffey, S., Williams, M. J. A., Phillips, L. V., & Jones, G. T. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002150 · Cited by 36
Self-citationGaibazzi, N., Rigo, F., Facchetti, R., Carerj, S., Giannattasio, C., Moreo, A. M., Mureddu, G. F., Salvetti, M., Grolla, E., Faden, G., et al. (2015) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jev222 · Cited by 35
Bob‐Manuel, T., Sharma, A., Nanda, A. S., Ardeshna, D. R., Skelton, W. P., & Khouzam, R. N. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2017.10.17 · Cited by 34
Limited versus full sternotomy for aortic valve replacement
Kirmani, B. H., Jones, S., Muir, A. D., Malaisrie, S. C., Chung, D. A., Williams, R. J., & Akowuah, E. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011793.pub3 · Cited by 33
Epigenome alterations in aortic valve stenosis and its related left ventricular hypertrophy
Gošev, I., Zeljko, M., Đurić, Ž., Nikolić, I., Gošev, M., Ivčević, S., Bešić, D., Legčević, Z., & Paić, F. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0406-7 · Cited by 33
Incident aortic stenosis in 49 449 men and 42 229 women investigated with routine echocardiography
Stewart, S., Chan, Y., Playford, D. A., & Strange, G. A. (2021) · Heart · doi:10.1136/heartjnl-2021-319697 · Cited by 30
Thonghong, T., Backer, O. D., & Søndergaard, L. (2018) · Open Heart · doi:10.1136/openhrt-2017-000753 · Cited by 30
Global burden of calcific aortic valve disease and attributable risk factors from 1990 to 2019
Yu, J., Wang, Z., Bao, Q., Lei, S., You, Y., Yin, Z., & Xie, X. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1003233 · Cited by 30
Minno, M. N. D. D., Minno, A. D., Songia, P., Ambrosino, P., Gripari, P., Ravani, A. L., Pepi, M., Rubba, P., Medda, E., Tremoli, E., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.08.122 · Cited by 28
Pathobiology of Lp(a) in calcific aortic valve disease
Mathieu, P., Arsenault, B. J., Boulanger, M., Bossé, Y., & Koschinsky, M. L. (2017) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2017.1367286 · Cited by 30
Visual scoring of aortic valve calcifications on low-dose CT in lung cancer screening
Zhu, Y., Wang, Y., Gioia, W. E., Yip, R., Jirapatnakul, A. C., Chung, M., Yankelevitz, D. F., & Henschke, C. I. (2020) · European Radiology · doi:10.1007/s00330-019-06614-w · Cited by 28
Engineering the aortic valve extracellular matrix through stages of development, aging, and disease
Scott, A. J., Simon, L. R., Hutson, H. N., Porras, A. M., & Masters, K. S. B. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.07.009 · Cited by 27
Yang, C., Xu, H., Jia, R., Jin, Z., Zhang, C., & Yuan, J. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11226733 · Cited by 26
Wang, D., Xiong, T., Yu, W., Liu, B., Wang, J., Xiao, K., & She, Q. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.650213 · Cited by 25
Diekmann, J., Neuser, J., Röhrich, M., Derlin, T., Zwadlo, C., Koenig, T., Weiberg, D., Jäckle, F., Kempf, T., Roß, T. L., et al. (2023) · Journal of Nuclear Medicine · doi:10.2967/jnumed.122.265147 · Cited by 27
Valerio, V., Myasoedova, V. A., Moschetta, D., Porro, B., Perrucci, G. L., Cavalca, V., Cavallotti, L., Songia, P., & Poggio, P. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8040552 · Cited by 24
Degenerative Aortic Stenosis, Dyslipidemia and Possibilities of Medical Treatment
Kleinauskienė, R., & Jonkaitienė, R. (2018) · Medicina · doi:10.3390/medicina54020024 · Cited by 25
Structural Heart Disease Emergencies
Jentzer, J., Ternus, B., Eleid, M., & Rihal, C. (2020) · Journal of Intensive Care Medicine · doi:10.1177/0885066620918776 · Cited by 23
Bakaeen, F. G., Rosengart, T. K., & Carabello, B. A. (2017) · Annals of Internal Medicine · doi:10.7326/aitc201701030 · Cited by 24
Unloading the Stenotic Path to Identifying Medical Therapy for Calcific Aortic Valve Disease
Lindman, B. R., & Merryman, W. D. (2021) · Circulation · doi:10.1161/circulationaha.120.052531 · Cited by 23
Rubin, J., Aggarwal, S., Swett, K., Kirtane, A., Kodali, S., Nazif, T., Pu, M., Dadhania, R., Kaplan, R., & Rodriguez, C. (2019) · Mayo Clinic proceedings · doi:10.1016/j.mayocp.2018.12.035 · Cited by 15
Heat shock protein 90 is downregulated in calcific aortic valve disease
Weisell, J., Ohukainen, P., Näpänkangas, J. P., Ohlmeier, S., Bergmann, U., Peltonen, T. O., Taskinen, P., Ruskoaho, H. J., & Rysä, J. (2019) · BMC Cardiovascular Disorders · doi:10.1186/s12872-019-01294-2 · Cited by 22
Yamaura, Y., Watanabe, N., Shimaya, M., Tomita, Y., Fukaya, T., & Yoshida, K. (2019) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.119.008901 · Cited by 21
Henein, M. Y., Hällgren, P., Holmgren, A., Sörensen, K., Ibrahimi, P., Kofoed, K. F., Larsen, L. H., & Hassager, C. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.10.014 · Cited by 21
Aortic valve sclerosis as a marker of atherosclerosis: Novel insights from hepatic steatosis
Minno, M. N. D. D., Minno, A. D., Ambrosino, P., Songia, P., Tremoli, E., & Poggio, P. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.04.162 · Cited by 21
Grodecki, K., Olasińska-Wiśniewska, A., Cyran, A., Urbanowicz, T., Kwieciński, J., Geers, J., Tamarappoo, B. K., Perek, B., Gocoł, R., Nawara-Skipirzepa, J., et al. (2024) · Radiology · doi:10.1148/radiol.240229 · Cited by 20
FOXO1 regulates RUNX2 ubiquitination through SMURF2 in calcific aortic valve disease
Jiang, C., Yao, D., Liu, Z., Zheng, Y., Chen, M., Yim, W. Y., Zheng, Q., Zhang, T., Fan, L., Fan, Z., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103215 · Cited by 20
Zhang, C., Liu, J., & Qin, S. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263378 · Cited by 20
Wang, Y.-T., Tao, J., Maimaiti, A., Adi, D., Yang, Y.-N., Li, X.-M., Ma, X., Liu, F., Chen, B., & Ma, Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174490 · Cited by 20
Faggiano, A., Santangelo, G., Carugo, S., Pressman, G. S., Picano, E., & Faggiano, P. M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081668 · Cited by 21
Tokodi, M., Shah, R., Jamthikar, A. D., Craig, N. J., Hamirani, Y. S., Casaclang‐Verzosa, G., Hahn, R. T., Dweck, M. R., Pîbarot, P., Yanamala, N. V. K., et al. (2024) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2024.07.017 · Cited by 19
Moderate aortic stenosis: culprit or bystander?
Pankayatselvan, V., Raber, I., Playford, D. A., Stewart, S., Strange, G. A., & Strom, J. B. (2022) · Open Heart · doi:10.1136/openhrt-2021-001743 · Cited by 19
An, Y., Wang, Y., Ma, Y.-T., Wulasihan, M., Huang, Y., Adi, D., Yang, Y., Ma, X., Li, X., Xie, X., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128965 · Cited by 19
Zhu, Y., Yip, R., Shemesh, J., Jirapatnakul, A. C., Yankelevitz, D. F., & Henschke, C. I. (2020) · European Radiology · doi:10.1007/s00330-020-07049-4 · Cited by 19
Khurrami, L., Møller, J. E., Lindholt, J. S., Urbonavičienė, G., Steffensen, F. H., Lambrechtsen, J., Karon, M., Frost, L., Busk, M., Egstrup, K., et al. (2021) · Heart · doi:10.1136/heartjnl-2021-319023 · Cited by 20
Aortic Valve Stenosis and Cardiac Amyloidosis: A Misleading Association
Bonelli, A., París, S. C., Nardi, M., Henein, M. Y., Agricola, E., Troise, G., & Faggiano, P. M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10184234 · Cited by 18
Molnár, A., Pásztor, D. T., & Merkely, B. P. (2022) · Cells · doi:10.3390/cells11213389 · Cited by 18
Han, Y., Zhang, J., Yang, Z., Jian, W., Gao, S., Liu, Y., Liu, Y., He, S., Zhu, Y., Zhang, C., et al. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2023.06.004 · Cited by 20
Wang, A., Adeli, A., Kylhammar, D., Swahn, E., Engvall, J. E., Lind, L., Söderberg, S., Blomberg, A., Engström, G., Spaak, J., et al. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf157 · Cited by 19
Taylor, A. P., Freeman, R. V., Bartek, M. A., & Shalhub, S. (2018) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2018.09.050 · Cited by 17
Wen, L., Lin, X., Hu, D., Li, J., Xie, K., Li, S., Su, S., Duan, X., Zhong, G., Lin, Y., et al. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119109 · Cited by 17
Bouhamida, E., Morciano, G., Pedriali, G., Ramaccini, D., Tremoli, E., Giorgi, C., Pinton, P., & Patergnani, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311105 · Cited by 19
Singh, G. K., van der Bijl, P., Goedemans, L., Vollema, E. M., Abou, R., Marsan, N. A., Bax, J. J., & Delgado, V. (2021) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2021.05.012 · Cited by 16
Xiong, T., Shen, H., Pu, L., Zhang, T.-C., Zhan, X., Fu, T., Dai, Y.-H., & Li, Y.-X. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.832591 · Cited by 16
Oikawa, M., Owada, T., Yamauchi, H., Misaka, T., Machii, H., Yamaki, T., Sugimoto, K., Kunii, H., Nakazato, K., Suzuki, H., et al. (2016) · BioMed Research International · doi:10.1155/2016/2174657 · Cited by 16
Age-related Cardiovascular Changes and Diseases
Seki, A., & Fishbein, M. C. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420219-1.00002-1 · Cited by 15
Aortic Valve Calcification and Risk of Stroke
Bos, D., Bozorgpourniazi, A., Mutlu, Ü., Kavousi, M., Vernooij, M. W., Moelker, A. D., Franco, O. H., Koudstaal, P. J., Ikram, M. A., & van der Lugt, A. (2016) · Stroke · doi:10.1161/strokeaha.116.015200 · Cited by 15
Masri, A., Chen, Y., Colavecchia, A. C., Benjumea, D., Crowley, A., Jhingran, P. M., Kent, M., Wogen, J., Pankratova, C., Alvir, J. M. J., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.123.033251 · Cited by 14
Exploiting novel valve interstitial cell lines to study calcific aortic valve disease
Tsang, H., Cui, L., Farquharson, C., CORCORAN, B. M., SUMMERS, K. M., & MacRae, V. E. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.8163 · Cited by 15
Robot-assisted real-time magnetic resonance image–guided transcatheter aortic valve replacement
Miller, J. G., Li, M., Mazilu, D., Hunt, T. J., & Horvath, K. A. (2015) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2015.11.047 · Cited by 14
Expression of connexin 43 protein in cardiomyocytes of heart failure mouse model
Liu, S., Yang, L., Zhao, Y., Zhang, Q., Lin, T.-C., Lin, K., Guo, J., & Yan, Y. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1028558 · Cited by 13
He, S., Deng, H., Jiang, J., Liu, F., Liao, H., Xue, Y., Zheng, M., Li, H., & Wu, S. (2021) · BioMed Research International · doi:10.1155/2021/9982569 · Cited by 14
Lee, H., Kim, S. M., Lee, K. S., Park, S. W., Chung, M. J., Cho, H., Jung, J. I., Jang, H. W., Jung, S., & Goo, J. (2016) · Medicine · doi:10.1097/md.0000000000003710 · Cited by 14
Lindman, B. R., Perry, A., Lance, M. L., Amancherla, K. V., Kim, N., Sheng, Q., Lin, P., Pfeiffer, R. D., Farber‐Eger, E. H., Fearon, W. F., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62201-2 · Cited by 15
Increased serum chemerin level to predict early onset of aortic valve stenosis
Lurins, J., Lūriņa, D., Tretjakovs, P., Mackēvičs, V., Lejnieks, A., Rapisarda, V., & Baylon, V. (2017) · Biomedical Reports · doi:10.3892/br.2017.1010 · Cited by 12
Kurasawa, S., Okazaki, M., Imaizumi, T., Kondo, T., Hishida, M., Nishibori, N., Takeda, Y., Kasuga, H., & Maruyama, S. (2023) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jead020 · Cited by 12
Association Between Aortic Valve Sclerosis and Clonal Hematopoiesis of Indeterminate Potential
Kim, M., Kim, J. J., Lee, S., Shim, Y., Lee, H., Bae, S., Son, N., Shin, S., & Jung, I. H. (2024) · Annals of Laboratory Medicine · doi:10.3343/alm.2023.0268 · Cited by 12
COSTA, J. F., Ali, A. E., Morland, D., Dejust, S., Papathanassiou, D., Nazeyrollas, P., & Metz, D. (2024) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2024.04.007 · Cited by 12
Evaluation of Whole Blood Viscosity in Patients with Aortic Sclerosis.
Duyuler, P. T., Duyuler, S., İleri, M., Demir, M., Dolu, A. K., & Başyiğit, F. (2017) · PubMed Central · Cited by 12
Zhang, F., Cheng, N., Han, Y., Zhang, C., & Zhang, H. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.722564 · Cited by 12
Horne, C. E., Goda, T. S., Nifong, L. W., Kypson, A. P., O’Neal, W. T., Kindell, L. C., Jindal, C., & Efird, J. T. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16010073 · Cited by 12
Sattar, Y., Rauf, H., Bareeqa, S. B., Ullah, W., & Myla, M. (2019) · Cureus · doi:10.7759/cureus.6431 · Cited by 13
A novel in vivo assessment of fluid dynamics on aortic valve leaflet using epi‐aortic echocardiogram
Hayashi, H., Akiyama, K., Itatani, K., DeRoo, S. C., Sanchez, J. E., Ferrari, G. M., Colombo, P. C., Takeda, K., Wu, I. Y., Kainuma, A., et al. (2020) · Echocardiography · doi:10.1111/echo.14596 · Cited by 12
Aortic Valve Sclerosis in High-Risk Coronary Artery Disease Patients
Myasoedova, V. A., Genovese, S., Cavallotti, L., Bonomi, A., Chiesa, M., Campodonico, J., Rondinelli, M., Cosentino, N., Baldassarre, D., Veglia, F., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.711899 · Cited by 12
Circulating Monocyte Subsets and Transcatheter Aortic Valve Replacement
Lassalle, F., Rosa, M., Staels, B., BELLE, E. V., Susen, S., & Dupont, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105303 · Cited by 14
Real-time magnetic resonance imaging–guided transcatheter aortic valve replacement
Miller, J. G., Li, M., Mazilu, D., Hunt, T. J., & Horvath, K. A. (2015) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2015.11.024 · Cited by 12
Growing importance of valvular heart disease in the elderly
Chen, Y., & Yiu, K. (2016) · Journal of Thoracic Disease · doi:10.21037/jtd.2016.12.23 · Cited by 12
Metadata
- Authors
- Coffey, S., Cox, B., & Williams, M. J. A.
- Affiliations
- University of Oxford (GB)
- University of Otago (NZ)
- Corresponding author
- Coffey, Sean
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 63
- Issue
- 25
- Pages
- 2852-2861
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W95580629
- Cited by
- 255
- References
- 41
- Citations by year
- 2026: 17 · 2025: 33 · 2024: 25 · 2023: 26 · 2022: 20 · 2021: 33 · 2020: 18 · 2019: 26 · 2018: 15 · 2017: 16 · 2016: 9 · 2015: 14 · 2014: 3
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tony Hocken Scholarship
- Director's Cancer Research Trust
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Aortic Disease and Treatment Approaches
- Keywords
- aortic valve sclerosis, aortic valve calcification, prevalence, incidence, disease progression, aortic stenosis, cardiovascular mortality, stroke, coronary events, all-cause mortality, age-related prevalence, cardiovascular risk
- MeSH terms
- Aortic Valve Stenosis, Heart Rate, Humans, Prognosis, Risk Factors, Global Health, Incidence, Prevalence, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
