The DOI matches its Crossref record; 43 of the 45 references it cites were found in a registry or an index.
Effects of Vitamin D on Cardiac Function in Patients With Chronic HF
Open accessAbstract
BACKGROUND: Patients with chronic heart failure (HF) secondary to left ventricular systolic dysfunction (LVSD) are frequently deficient in vitamin D. Low vitamin D levels are associated with a worse prognosis. OBJECTIVES: The VINDICATE (VitamIN D treatIng patients with Chronic heArT failurE) study was undertaken to establish safety and efficacy of high-dose 25 (OH) vitamin D3 (cholecalciferol) supplementation in patients with chronic HF due to LVSD. METHODS: We enrolled 229 patients (179 men) with chronic HF due to LVSD and vitamin D deficiency (cholecalciferol <50 nmol/l [<20 ng/ml]). Participants were allocated to 1 year of vitamin D3 supplementation (4,000 IU [100 μg] daily) or matching non-calcium-based placebo. The primary endpoint was change in 6-minute walk distance between baseline and 12 months. Secondary endpoints included change in LV ejection fraction at 1 year, and safety measures of renal function and serum calcium concentration assessed every 3 months. RESULTS: One year of high-dose vitamin D3 supplementation did not improve 6-min walk distance at 1 year, but was associated with a significant improvement in cardiac function (LV ejection fraction +6.07% [95% confidence interval (CI): 3.20 to 8.95; p < 0.0001]); and a reversal of LV remodeling (LV end diastolic diameter -2.49 mm [95% CI: -4.09 to -0.90; p = 0.002] and LV end systolic diameter -2.09 mm [95% CI: -4.11 to -0.06 p = 0.043]). CONCLUSIONS: One year of 100 μg daily vitamin D3 supplementation does not improve 6-min walk distance but has beneficial effects on LV structure and function in patients on contemporary optimal medical therapy. Further studies are necessary to determine whether these translate to improvements in outcomes. (VitamIN D Treating patIents With Chronic heArT failurE [VINDICATE]; NCT01619891).
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“The low sensitivity of NYHA classification and 6 min walk test limits their ability to measure change over time”
From Prioritizing symptom management in the treatment of chronic heart failure (2020) · cites this paper as [38]
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“while the additional equipment to measure metabolic gas exchange limits the widespread applicability of cardiopulmonary exercise testing. 38 , 39”
From Prioritizing symptom management in the treatment of chronic heart failure (2020) · cites this paper as [38]
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Holick, M. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmra070553 · Cited by 13,720
Lang, R. M., Badano, L. P., Mor-Avi, V., Afilalo, J., Armstrong, A., Ernande, L., Flachskampf, F. A., Foster, E., Goldstein, S. A., Kuznetsova, T., et al. (2015) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2014.10.003 · Cited by 12,362
Forecasting the Impact of Heart Failure in the United States
Heidenreich, P. A., Albert, N. M., Allen, L. A., Bluemke, D. A., Butler, J., Fonarow, G. C., Ikonomidis, J. S., Khavjou, O., Konstam, M. A., Maddox, T. M., et al. (2013) · Circulation Heart Failure · doi:10.1161/hhf.0b013e318291329a · Cited by 2,872
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Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency
Anker, S. D., Comin Colet, J., Filippatos, G., Willenheimer, R., Dickstein, K., Drexler, H., Lüscher, T. F., Bart, B., Banasiak, W., Niegowska, J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0908355 · Cited by 2,083
Clinical epidemiology of heart failure
Mosterd, A., & Hoes, A. W. (2007) · Heart · doi:10.1136/hrt.2003.025270 · Cited by 1,921
1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
Li, Y. C., Kong, J., Wei, M., Chen, Z.-F., Liu, S. Q., & Cao, L.-P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215219 · Cited by 1,625
Schleithoff, S. S., Zittermann, A., Tenderich, G., Berthold, H. K., Stehle, P., & Koerfer, R. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.4.754 · Cited by 928
Mechanisms and Models in Heart Failure
Mann, D. L., & Bristow, M. R. (2005) · Circulation · doi:10.1161/circulationaha.104.500546 · Cited by 885
Rosen, C. J. (2011) · New England Journal of Medicine · doi:10.1056/nejmcp1009570 · Cited by 829
Flagged first, then by citations
2 of the 45 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Lowry, 2015, Vitamin d supplementation improves the size and function of the left ventricle in patients with heart failure, Eur Heart J, 36, A665
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Environmental Determinants of Cardiovascular Disease
Bhatnagar, A. (2017) · Circulation Research · doi:10.1161/circresaha.117.306458 · Cited by 636
Atherton, J. J., Sindone, A. P., Pasquale, C. G. D., Driscoll, A. L., Macdonald, P. S., Hopper, I., Kistler, P. M., Briffa, T. G., Wong, J., Abhayaratna, W. P., et al. (2018) · Heart Lung and Circulation · doi:10.1016/j.hlc.2018.06.1042 · Cited by 439
Association between vitamin D supplementation and mortality: systematic review and meta-analysis
Zhang, Y., Fang, F., Tang, J., Jia, L., Feng, Y., Xu, P., & Faramand, A. M. (2019) · BMJ · doi:10.1136/bmj.l4673 · Cited by 402
MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19
Bilezikian, J. P., Bikle, D. D., Hewison, M., Lazaretti‐Castro, M., Formenti, A. M., Gupta, A., Madhavan, M. V., Nair, N., Babalyan, V., Hutchings, N. J., et al. (2020) · European Journal of Endocrinology · doi:10.1530/eje-20-0665 · Cited by 349
Vitamin D and cardiovascular health
de la Guía-Galipienso, F., Martínez‐Ferrán, M., Vallecillo, N., Lavie, C. J., Sanchis‐Gomar, F., & Pareja-Galeano, H. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.12.025 · Cited by 364
Metadata
- Authors
- Witte, K. K., Byrom, R., Gierula, J., Paton, M. F., Jamil, H. A., Lowry, J. E., Gillott, R. G., Barnes, S. A., Chumun, H., Kearney, L. C., Greenwood, J. P., Plein, S., Law, G. R., Pavitt, S., Barth, J. H., Cubbon, R. M., & Kearney, M. T.
- Affiliations
- University of Leeds (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Corresponding author
- Witte, Klaus K.
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 67
- Issue
- 22
- Pages
- 2593-2603
- ISSN
- 0735-1097 (ISSN-L)
- PMC
- PMC4893154
- OpenAlex
- W2338797564
- Cited by
- 229
- References
- 45
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 18 · 2023: 23 · 2022: 21 · 2021: 23 · 2020: 26 · 2019: 22 · 2018: 34 · 2017: 30 · 2016: 14
- FWCI
- 30.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of the American College of Cardiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Lincoln Repository (University of Lincoln) (acceptedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institute for Health and Care Research (HCS DRF-2014-05-006)
- British Heart Foundation (RG/09/010/28087, FS/12/80/29821, FS/10/028/28252)
- University of Leeds
- National Institutes of Health
- Medical Research Council (MR/J00281X/1)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- vitamin D supplementation, chronic heart failure, left ventricular systolic dysfunction, vitamin D deficiency, 25-hydroxyvitamin D3, vitamin D3, left ventricular ejection fraction, left ventricular remodeling, 6-minute walk distance, renal function, serum calcium
- MeSH terms
- Walk Test, Aged, Calcifediol, Calcitriol, Cholecalciferol, Double-Blind Method, Echocardiography, Female, Heart Failure, Heart Ventricles, Humans, Male, Middle Aged, Stroke Volume, Systole, Vitamins, Ventricular Dysfunction, Left, Magnetic Resonance Imaging, Cine, Ventricular Remodeling
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