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Cited by 229Vitamin D Research StudiesHeart Failure Treatment and ManagementCardiovascular Function and Risk Factors

The DOI matches its Crossref record; 43 of the 45 references it cites were found in a registry or an index.

Effects of Vitamin D on Cardiac Function in Patients With Chronic HF

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Witte, Klaus K., Byrom, Rowena, Gierula, John, Paton, Maria F., Jamil, Haqeel A., Lowry, Judith E., Gillott, Richard G., Barnes, Sally A., Chumun, Hemant, Kearney, Lorraine C., Greenwood, John P., Plein, Sven, Law, Graham R., Pavitt, Sue, Barth, Julian H., Cubbon, Richard M., Kearney, Mark T.·2016·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2016.03.508PMC PMC4893154
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Abstract

BACKGROUND: Patients with chronic heart failure (HF) secondary to left ventricular systolic dysfunction (LVSD) are frequently deficient in vitamin D. Low vitamin D levels are associated with a worse prognosis. OBJECTIVES: The VINDICATE (VitamIN D treatIng patients with Chronic heArT failurE) study was undertaken to establish safety and efficacy of high-dose 25 (OH) vitamin D3 (cholecalciferol) supplementation in patients with chronic HF due to LVSD. METHODS: We enrolled 229 patients (179 men) with chronic HF due to LVSD and vitamin D deficiency (cholecalciferol <50 nmol/l [<20 ng/ml]). Participants were allocated to 1 year of vitamin D3 supplementation (4,000 IU [100 μg] daily) or matching non-calcium-based placebo. The primary endpoint was change in 6-minute walk distance between baseline and 12 months. Secondary endpoints included change in LV ejection fraction at 1 year, and safety measures of renal function and serum calcium concentration assessed every 3 months. RESULTS: One year of high-dose vitamin D3 supplementation did not improve 6-min walk distance at 1 year, but was associated with a significant improvement in cardiac function (LV ejection fraction +6.07% [95% confidence interval (CI): 3.20 to 8.95; p < 0.0001]); and a reversal of LV remodeling (LV end diastolic diameter -2.49 mm [95% CI: -4.09 to -0.90; p = 0.002] and LV end systolic diameter -2.09 mm [95% CI: -4.11 to -0.06 p = 0.043]). CONCLUSIONS: One year of 100 μg daily vitamin D3 supplementation does not improve 6-min walk distance but has beneficial effects on LV structure and function in patients on contemporary optimal medical therapy. Further studies are necessary to determine whether these translate to improvements in outcomes. (VitamIN D Treating patIents With Chronic heArT failurE [VINDICATE]; NCT01619891).

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Crossref · 10.1016/j.jacc.2016.03.508

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Figure 1 Consort Diagram Demonstrating Patient Enrollment and Disposition for VINDICATE VINDICATE = VitamIN D treatIng patients with Chronic heArT failurE.
Figure 1 Consort Diagram Demonstrating Patient Enrollment and Disposition for VINDICATE VINDICATE = VitamIN D treatIng patients with Chronic heArT failurE.CC BY · PubMed Central
Figure 2 Median and Interquartile Ranges for Vitamin D, Creatinine, Calcium, and Parathyroid Concentrations at 3 Monthly Time Points in VINDICATE by Treatment Allocation Vitamin D concentrations are described in relation to deficiency (green line), sufficiency (orange line), and the accepted upper limit for hypervitaminosis D (red line). Serum calcium levels are described in relation to upper limit of normal range (red line), and serum parathyroid hormone concentrations in relation to the normal range (between red lines). Conversion factors: vitamin D nmol/l · 0.4 = ng/ml; creatinine mmol/l · 0.11 = mg/dl; calcium mmol/l · 4 = mg/dl; parathyroid hormone pmol/l · 9.4 = pg/ml. VINDICATE = VitamIN D treatIng patients with Chronic heArT failurE.
Figure 2 Median and Interquartile Ranges for Vitamin D, Creatinine, Calcium, and Parathyroid Concentrations at 3 Monthly Time Points in VINDICATE by Treatment Allocation Vitamin D concentrations are described in relation to deficiency (green line), sufficiency (orange line), and the accepted upper limit for hypervitaminosis D (red line). Serum calcium levels are described in relation to upper limit of normal range (red line), and serum parathyroid hormone concentrations in relation to the normal range (between red lines). Conversion factors: vitamin D nmol/l · 0.4 = ng/ml; creatinine mmol/l · 0.11 = mg/dl; calcium mmol/l · 4 = mg/dl; parathyroid hormone pmol/l · 9.4 = pg/ml. VINDICATE = VitamIN D treatIng patients with Chronic heArT failurE.CC BY · PubMed Central
Figure 3 Median and Interquartile Ranges for 6-Minute Walk Test Distance, and LVEF, LVEDD, and LVEDV Measured by Echocardiography at Baseline and Final Visit in VINDICATE by Treatment Allocation LVEDD = left ventricular end-diastolic dimension; LVEDV = left ventricular end-diastolic volume; LVEF = left ventricular ejection fraction; VINDICATE = VitamIN D treatIng patients with Chronic heArT failurE.
Figure 3 Median and Interquartile Ranges for 6-Minute Walk Test Distance, and LVEF, LVEDD, and LVEDV Measured by Echocardiography at Baseline and Final Visit in VINDICATE by Treatment Allocation LVEDD = left ventricular end-diastolic dimension; LVEDV = left ventricular end-diastolic volume; LVEF = left ventricular ejection fraction; VINDICATE = VitamIN D treatIng patients with Chronic heArT failurE.CC BY · PubMed Central
Central Illustration Vitamin D in Chronic Heart Failure: Impact on Left Ventricular Structure and Function Vitamin D improves left ventricular ejection fractions and reduces left ventricular dimensions and volumes.
Central Illustration Vitamin D in Chronic Heart Failure: Impact on Left Ventricular Structure and Function Vitamin D improves left ventricular ejection fractions and reduces left ventricular dimensions and volumes.CC BY · PubMed Central

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  1. Lowry, 2015, Vitamin d supplementation improves the size and function of the left ventricle in patients with heart failure, Eur Heart J, 36, A665

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Metadata

Authors
Witte, K. K., Byrom, R., Gierula, J., Paton, M. F., Jamil, H. A., Lowry, J. E., Gillott, R. G., Barnes, S. A., Chumun, H., Kearney, L. C., Greenwood, J. P., Plein, S., Law, G. R., Pavitt, S., Barth, J. H., Cubbon, R. M., & Kearney, M. T.
Affiliations
  • University of Leeds (GB)
  • Leeds Teaching Hospitals NHS Trust (GB)
Corresponding author
Witte, Klaus K.
ORCID
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2016-06
Volume
67
Issue
22
Pages
2593-2603
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2016.03.508
PMC
PMC4893154
OpenAlex
W2338797564
Cited by
229
References
45
Citations by year
2026: 7 · 2025: 10 · 2024: 18 · 2023: 23 · 2022: 21 · 2021: 23 · 2020: 26 · 2019: 22 · 2018: 34 · 2017: 30 · 2016: 14
FWCI
30.30
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American College of Cardiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Lincoln Repository (University of Lincoln) (acceptedVersion)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
  • Figshare (submittedVersion, cc-by)
Funders
  • National Institute for Health and Care Research (HCS DRF-2014-05-006)
  • British Heart Foundation (RG/09/010/28087, FS/12/80/29821, FS/10/028/28252)
  • University of Leeds
  • National Institutes of Health
  • Medical Research Council (MR/J00281X/1)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
vitamin D supplementation, chronic heart failure, left ventricular systolic dysfunction, vitamin D deficiency, 25-hydroxyvitamin D3, vitamin D3, left ventricular ejection fraction, left ventricular remodeling, 6-minute walk distance, renal function, serum calcium
MeSH terms
Walk Test, Aged, Calcifediol, Calcitriol, Cholecalciferol, Double-Blind Method, Echocardiography, Female, Heart Failure, Heart Ventricles, Humans, Male, Middle Aged, Stroke Volume, Systole, Vitamins, Ventricular Dysfunction, Left, Magnetic Resonance Imaging, Cine, Ventricular Remodeling

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