The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
The Mitral Annulus Disjunction Arrhythmic Syndrome
Open accessAbstract
BACKGROUND: Mitral annulus disjunction (MAD) is an abnormal atrial displacement of the mitral valve leaflet hinge point. MAD has been associated with mitral valve prolapse (MVP) and sudden cardiac death. OBJECTIVES: The purpose of this study was to describe the clinical presentation, MAD morphology, association with MVP, and ventricular arrhythmias in patients with MAD. METHODS: The authors clinically examined patients with MAD. By echocardiography, the authors assessed the presence of MVP and measured MAD distance in parasternal long axis. Using cardiac magnetic resonance (CMR), the authors assessed circumferential MAD in the annular plane, longitudinal MAD distance, and myocardial fibrosis. Aborted cardiac arrest and sustained ventricular tachycardia were defined as severe arrhythmic events. RESULTS: The authors included 116 patients with MAD (age 49 ± 15 years; 60% female). Palpitations were the most common symptom (71%). Severe arrhythmic events occurred in 14 (12%) patients. Longitudinal MAD distance measured by CMR was 3.0 mm (interquartile range [IQR]: 0 to 7.0 mm) and circumferential MAD was 150° (IQR: 90° to 210°). Patients with severe arrhythmic events were younger (age 37 ± 13 years vs. 51 ± 14 years; p = 0.001), had lower ejection fraction (51 ± 5% vs. 57 ± 7%; p = 0.002) and had more frequently papillary muscle fibrosis (4 [36%] vs. 6 [9%]; p = 0.03). MVP was evident in 90 (78%) patients and was not associated with ventricular arrhythmia. CONCLUSIONS: Ventricular arrhythmias were frequent in patients with MAD. A total of 26 (22%) patients with MAD did not have MVP, and MVP was not associated with arrhythmic events, indicating MAD itself as an arrhythmogenic entity. MAD was detected around a large part of the mitral annulus circumference and was interspersed with normal tissue.
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Lang, R. M., Badano, L. P., Mor-Avi, V., Afilalo, J., Armstrong, A., Ernande, L., Flachskampf, F. A., Foster, E., Goldstein, S. A., Kuznetsova, T., et al. (2015) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2014.10.003 · Cited by 12,362
Lang, R. M., Badano, L. P., Mor-Avi, V., Afilalo, J., Armstrong, A., Ernande, L., Flachskampf, F. A., Foster, E., Goldstein, S. A., Kuznetsova, T., et al. (2015) · European Heart Journal – Cardiovascular Imaging · doi:10.1093/ehjci/jev014 · Cited by 8,361
2017 ESC/EACTS Guidelines for the management of valvular heart disease
Baumgartner, H., Falk, V., Bax, J. J., De Bonis, M., Hamm, C., Holm, P. J., Iung, B., Lancellotti, P., Lansac, E., Rodriguez Muñoz, D., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx391 · Cited by 6,243
Recommendations for Noninvasive Evaluation of Native Valvular Regurgitation
Zoghbi, W. A., Adams, D., Bonow, R. O., Enriquez-Sarano, M., Foster, E., Grayburn, P. A., Hahn, R. T., Han, Y., Hung, J., Lang, R. M., et al. (2017) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2017.01.007 · Cited by 3,556
Prevalence and Clinical Outcome of Mitral-Valve Prolapse
Freed, L. A., Levy, D., Levine, R. A., Larson, M. G., Evans, J. C., Fuller, D. L., Lehman, B., & Benjamin, E. J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907013410101 · Cited by 1,169
Arrhythmic Mitral Valve Prolapse and Sudden Cardiac Death
Basso, C., Perazzolo Marra, M., Rizzo, S., De Lazzari, M., Giorgi, B., Cipriani, A., Frigo, A. C., Rigato, I., Migliore, F., Pilichou, K., et al. (2015) · Circulation · doi:10.1161/circulationaha.115.016291 · Cited by 625
Echocardiographically Documented Mitral-Valve Prolapse: Long-Term Follow-up of 237 Patients
Nishimura, R. A., McGoon, M. D., Shub, C., Miller, F. A., Ilstrup, D. M., & Tajik, A. J. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511213132101 · Cited by 589
Morphofunctional Abnormalities of Mitral Annulus and Arrhythmic Mitral Valve Prolapse
Perazzolo Marra, M., Basso, C., De Lazzari, M., Rizzo, S., Cipriani, A., Giorgi, B., Lacognata, C., Rigato, I., Migliore, F., Pilichou, K., et al. (2016) · Circulation: Cardiovascular Imaging · doi:10.1161/circimaging.116.005030 · Cited by 373
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The Association of Floppy Mitral Valve with Disjunction of the Mitral Annulus Fibrosus
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2021 ESC/EACTS Guidelines for the management of valvular heart disease
Vahanian, A., Beyersdorf, F., Praz, F., Milojevic, M., Baldus, S., Bauersachs, J., Capodanno, D., Conradi, L., De Bonis, M., De Paulis, R., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehab395 · Cited by 5,685
Self-citation2020 ESC guidelines on sports cardiology and exercise in patients with cardiovascular disease
Pelliccia, A., Sharma, S., Gati, S., Bäck, M., Börjesson, M., Caselli, S., Collet, J.-P., Corrado, D., Drezner, J. A., Halle, M., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehaa605 · Cited by 1,958
Self-citationLancellotti, P., Pibarot, P., Chambers, J., La Canna, G., Pepi, M., Dulgheru, R., Dweck, M., Delgado, V., Garbi, M., Vannan, M. A., et al. (2022) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeab253 · Cited by 474
Metadata
- Authors
- Dejgaard, L. A., Skjølsvik, E. T., Lie, Ø. H., Ribe, M., Stokke, M. K., Hegbom, F., Scheirlynck, E. S., Gjertsen, E., Andresen, K., Helle-Valle, T. M., Hopp, E., Edvardsen, T., & Haugaa, K. H.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 72
- Issue
- 14
- Pages
- 1600-1609
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2891096905
- Cited by
- 429
- References
- 17
- FWCI
- 23.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Dejgaard, L. A., Skjølsvik, E. T., Lie, Ø. H., Ribe, M., Stokke, M. K., Hegbom, F., Scheirlynck, E. S., Gjertsen, E., Andresen, K., Helle-Valle, T. M., Hopp, E., Edvardsen, T., & Haugaa, K. H. (2018). The Mitral Annulus Disjunction Arrhythmic Syndrome. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2018.07.070
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