Cited by 477Cardiovascular and exercise physiologyHeart Failure Treatment and ManagementHeart rate and cardiovascular health

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Exercise Intolerance in Patients With Heart Failure

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Del Buono, Marco Giuseppe, Arena, Ross, Borlaug, Barry A., Carbone, Salvatore, Canada, Justin M., Kirkman, Danielle L., Garten, Ryan, Rodriguez-Miguelez, Paula, Guazzi, Marco, Lavie, Carl J., Abbate, Antonio·2019·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2019.01.072

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Abstract

Exercise intolerance is the cardinal symptom of heart failure (HF) and is of crucial relevance, because it is associated with a poor quality of life and increased mortality. While impaired cardiac reserve is considered to be central in HF, reduced exercise and functional capacity are the result of key patient characteristics and multisystem dysfunction, including aging, impaired pulmonary reserve, as well as peripheral and respiratory skeletal muscle dysfunction. We herein review the different modalities to quantify exercise intolerance, the pathophysiology of HF, and comorbid conditions as they lead to reductions in exercise and functional capacity, highlighting the fact that distinct causes may coexist and variably contribute to exercise intolerance in patients with HF.

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Pachen, M., Chen, S., Chang, J. W. ‐., Pauža, A. G., Shanks, J. A., George, B., Paton, J. F. R., & Ramchandra, R. (2026) · The Journal of Physiology · doi:10.1113/jp291306
Reduced serum adiponectin and exercise predict depression in chronic heart failure patients and affect depressive-like behaviors in a mouse model
Yang, H., Du, Q., Zeng, F., & Li, B. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1835186
Association between the 30-s chair stand test and peak oxygen uptake in patients undergoing cardiopulmonary exercise testing: A large retrospective internal and external validation study
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DISFUNÇÃO MUSCULAR RESPIRATÓRIA E ALTERAÇÕES ULTRASSONOGRÁFICAS DO DIAFRAGMA EM IDOSOS COM INSUFICIÊNCIA CARDÍACA NA UTI SEGUNDO FRAÇÃO DE EJEÇÃO
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Diretriz Brasileira de Insuficiência Cardíaca – 2026
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Systemic Inflammation and Cardiorespiratory Fitness in Heart Failure: A Pooled Analysis of Anakinra Clinical Trials
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Self-citation
Cardiopulmonary exercise testing utilization and clinical outcomes among patients with heart failure across racial and ethnic groups
Rice, J., Furqan, Y., Elbanna, S., O’Leary, C., Ansari, S., & Albayyaa, M. (2026) · ESC Heart Failure · doi:10.1093/eschf/xvag231

Authors: Del Buono, M. G., Arena, R., Borlaug, B. A., Carbone, S., Canada, J. M., Kirkman, D. L., Garten, R., Rodriguez-Miguelez, P., Guazzi, M., Lavie, C. J., & Abbate, A.
Affiliations: University of Illinois Chicago (US)
Mayo Clinic (US)
Virginia Commonwealth University (US)
University of Milan (IT)
Ochsner Health System (US)
Corresponding author: Abbate, Antonio
ORCID: Arena, Ross
Borlaug, Barry A.
Carbone, Salvatore
Canada, Justin M.
Kirkman, Danielle L.
Garten, Ryan
Guazzi, Marco
Lavie, Carl J.
Abbate, Antonio
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2019-05
Volume: 73
Issue: 17
Pages: 2209-2225
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2019.01.072
OpenAlex: W2943775907
Cited by: 477
References: 130
Citations by year: 2026: 91 · 2025: 81 · 2024: 65 · 2023: 62 · 2022: 60 · 2021: 52 · 2020: 48 · 2019: 17
FWCI: 9.11
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 372 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
Funders: AstraZeneca
American College of Cardiology Foundation
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
Keywords: exercise intolerance, heart failure, functional capacity, cardiac reserve, pulmonary reserve, skeletal muscle dysfunction, aging, comorbidities, exercise testing, pathophysiology
MeSH terms: Aged, Heart Failure, Humans, Middle Aged, Oxygen Consumption, Prognosis, Severity of Illness Index, Vital Capacity, Exercise, Comorbidity, Exercise Tolerance, Risk Assessment

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Exercise Intolerance in Patients With Heart Failure

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