Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,112

The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.

Transthyretin Amyloid Cardiomyopathy

Open access
Ruberg, Frederick L., Grogan, Martha, Hanna, Mazen, Kelly, Jeffery W., Maurer, Mathew S.·2019·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2019.04.003
Open this paper in CoChat — free account

Abstract

Transthyretin amyloid cardiomyopathy (ATTR-CM) is an under-recognized cause of heart failure (HF) in older adults, resulting from myocardial deposition of misfolded transthyretin (TTR or prealbumin). Characteristic patterns of echocardiography and cardiac magnetic resonance imaging are strongly suggestive but not diagnostic. The diagnosis can be made with non-invasive nuclear imaging when there is no evidence of a monoclonal protein. Amyloid fibril formation results from a destabilizing mutation in hereditary ATTR amyloidosis (hATTR) or from an aging-linked process in wild-type ATTR amyloidosis (wtATTR). Recent studies suggest that up to 10–15% of older adults with HF may harbor unrecognized wtATTR. Associated features, including carpal tunnel syndrome and lumbar spinal stenosis, raise suspicion and may afford a means for early diagnosis. Previously treatable only by organ transplantation, pharmaceutical therapy that slows or halts ATTR-CM progression and favorably affects clinical outcomes is now available. Early recognition remains essential to afford the best treatment efficacy.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.jacc.2019.04.003

Cites

91 of 91 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 91 references

Cited by

See all 1,112

Metadata

Authors
Ruberg, F. L., Grogan, M., Hanna, M., Kelly, J. W., & Maurer, M. S.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2019-06
Volume
73
Issue
22
Pages
2872-2891
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2019.04.003
OpenAlex
W2948364217
Cited by
1,112
References
91
FWCI
32.44
Type
journal article
Language
en
Open access
bronze

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Transthyretin Amyloid Cardiomyopathy. https://app.cochat.ai/papers/10.1016/j.jacc.2019.04.003
The paper
Ruberg, F. L., Grogan, M., Hanna, M., Kelly, J. W., & Maurer, M. S. (2019). Transthyretin Amyloid Cardiomyopathy. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2019.04.003

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.