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Cited by 286

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Global Longitudinal Strain and Cardiac Events in Patients With Immune Checkpoint Inhibitor-Related Myocarditis

Open access
Awadalla, Magid, Mahmood, Syed S., Groarke, John D., Hassan, Malek Z.O., Nohria, Anju, Rokicki, Adam, Murphy, Sean P., Mercaldo, Nathaniel D., Zhang, Lili, Zlotoff, Daniel A., Reynolds, Kerry L., Alvi, Raza M., Banerji, Dahlia, Liu, Shiying, Heinzerling, Lucie M., Jones-O’Connor, Maeve, Bakar, Rula B., Cohen, Justine V., Kirchberger, Michael C., Sullivan, Ryan J., Gupta, Dipti, Mulligan, Connor P., Shah, Sachin P., Ganatra, Sarju, Rizvi, Muhammad A., Sahni, Gagan, Tocchetti, Carlo G., Lawrence, Donald P., Mahmoudi, Michael, Devereux, Richard B., Forrestal, Brian J., Mandawat, Anant, Lyon, Alexander R., Chen, Carol L., Barac, Ana, Hung, Judy, Thavendiranathan, Paaladinesh, Picard, Michael H., Thuny, Franck, Ederhy, Stephane, Fradley, Michael G., Neilan, Tomas G.·2020·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2019.11.049
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Abstract

Background: There is a need for improved methods for detection and risk stratification of myocarditis associated with immune checkpoint inhibitors (ICI’s). Global longitudinal strain (GLS) is a sensitive marker of cardiac-toxicity among patients receiving standard chemotherapy. There are no data on the use of GLS in ICI-myocarditis. Methods: We retrospectively compared echocardiographic GLS by speckle tracking at presentation with ICI-myocarditis (cases, n=101) and patients receiving ICI without myocarditis (controls, n=92). Where available, GLS was also measured pre-ICI in both groups. Major adverse cardiac events (MACE) was defined as a composite of cardiogenic shock, arrest, complete heart block, and cardiac death. Results: Cases and controls were similar in age, sex, and cancer type. At presentation with myocarditis, 61 cases (60%) had a normal EF. Pre-ICI, GLS was similar between cases and controls (20.3±2.6 vs. 20.6±2.0 %, p=0.60). There was no change in GLS among controls on an ICI without myocarditis (Pre-ICI vs. on ICI, 20.6±2.0 vs. 20.5±1.9%, p=0.41); in contrast, among cases, GLS decreased to 14.1±2.8%, (p<0.001). The GLS at presentation with myocarditis was lower among cases presenting with either a reduced (12.3±2.7%) or preserved EF (15.3±2.0%, p<0.001). Over a median follow-up of 162 days, 51 (51%) experienced MACE. The risk of MACE was higher with a lower GLS among patients with either a reduced or preserved EF. After adjustment for EF, each percent reduction in GLS was associated with a 1.5-fold increase in MACE among patients with a reduced EF (HR 1.5, CI 1.2–1.8) and a 4.4-fold increase with a preserved EF (HR 4.4, CI 2.4–7.8). Conclusion: GLS decreases with ICI-myocarditis and, compared to controls, was lower among cases presenting with either a preserved or reduced EF. Lower GLS was strongly associated with MACE in ICI-myocarditis presenting with either a preserved or reduced EF.

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Metadata

Authors
Awadalla, M., Mahmood, S. S., Groarke, J. D., Hassan, M. Z. O., Nohria, A., Rokicki, A., Murphy, S. P., Mercaldo, N. D., Zhang, L., Zlotoff, D. A., Reynolds, K. L., Alvi, R. M., Banerji, D., Liu, S., Heinzerling, L. M., Jones-O’Connor, M., Bakar, R. B., Cohen, J. V., Kirchberger, M. C., Sullivan, R. J., Gupta, D., Mulligan, C. P., Shah, S. P., Ganatra, S., Rizvi, M. A., Sahni, G., Tocchetti, C. G., Lawrence, D. P., Mahmoudi, M., Devereux, R. B., Forrestal, B. J., Mandawat, A., Lyon, A. R., Chen, C. L., Barac, A., Hung, J., Thavendiranathan, P., Picard, M. H., Thuny, F., Ederhy, S., Fradley, M. G., & Neilan, T. G.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2020-02
Volume
75
Issue
5
Pages
467-478
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2019.11.049
OpenAlex
W3003308809
Cited by
286
References
38
FWCI
25.28
Type
journal article
Language
en
Open access
bronze

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The paper
Awadalla, M., Mahmood, S. S., Groarke, J. D., Hassan, M. Z. O., Nohria, A., Rokicki, A., Murphy, S. P., Mercaldo, N. D., Zhang, L., Zlotoff, D. A., Reynolds, K. L., Alvi, R. M., Banerji, D., Liu, S., Heinzerling, L. M., Jones-O’Connor, M., Bakar, R. B., Cohen, J. V., Kirchberger, M. C., . . . Neilan, T. G. (2020). Global Longitudinal Strain and Cardiac Events in Patients With Immune Checkpoint Inhibitor-Related Myocarditis. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2019.11.049

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.