The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Clonal Hematopoiesis and Risk of Progression of Heart Failure With Reduced Left Ventricular Ejection Fraction
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Several studies have implicated CH as an independent risk factor for cardiovascular diseases, including myocardial infarction4,5, stroke6 and heart failure7–9, providing a potential explanation for the increased non-cancer mortality in individuals with CH.”
From Blockade of IL-6 signaling alleviates atherosclerosis in Tet2-deficient clonal hematopoiesis (2023) · cites this paper as [8]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536
Age-related clonal hematopoiesis associated with adverse outcomes
Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
Genovese, G., Kähler, A. K., Handsaker, R. E., Lindberg, J., Rose, S. A., Bakhoum, S. F., Chambert, K., Mick, E., Neale, B. M., Fromer, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409405 · Cited by 3,531
Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease
Jaiswal, S., Natarajan, P., Silver, A. J., Gibson, C. J., Bick, A. G., Shvartz, E., McConkey, M., Gupta, N., Gabriel, S., Ardissino, D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701719 · Cited by 2,683
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
Fuster, J. J., MacLauchlan, S., Zuriaga, M. A., Polackal, M. N., Ostriker, A. C., Chakraborty, R., Wu, C.-L., Sano, S., Muralidharan, S., Rius, C., et al. (2017) · Science · doi:10.1126/science.aag1381 · Cited by 1,536
Self-citationInherited causes of clonal haematopoiesis in 97,691 whole genomes
Bick, A. G., Weinstock, J. S., Nandakumar, S. K., Fulco, C. P., Bao, E. L., Zekavat, S. M., Szeto, M. D., Liao, X., Leventhal, M. J., Nasser, J., et al. (2020) · Nature · doi:10.1038/s41586-020-2819-2 · Cited by 733
Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults
Young, A. L., Challen, G. A., Birmann, B. M., & Druley, T. E. (2016) · Nature Communications · doi:10.1038/ncomms12484 · Cited by 692
Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis
McKerrell, T., Park, N., Moreno, T., Grove, C. S., Ponstingl, H., Stephens, J., Crawley, C., Craig, J., Scott, M. A., Hodkinson, C., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.005 · Cited by 534
Buscarlet, M., Provost, S., Zada, Y. F., Barhdadi, A., Bourgoin, V., Lépine, G., Mollica, L., Szuber, N., Dubé, M.-P., & Busque, L. (2017) · Blood · doi:10.1182/blood-2017-04-777029 · Cited by 383
Libby (2019) · doi:10.1016/j.jacc.2019.06.007 · Cited by 247
Wang, Y., Sano, S., Yura, Y., Ke, Z., Sano, M., Oshima, K., Ogawa, H., Horitani, K., Min, K.-D., Miura-Yura, E., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.135204 · Cited by 167
Self-citation
Research works printed but not linked: 21
- Vijg, 2020, Pathogenic mechanisms of somatic mutation and genome mosaicism in aging, Cell, 182, 12, 10.1016/j.cell.2020.06.024 · DOI · Paper page
- Xie, 2014, Age-related mutations associated with clonal hematopoietic expansion and malignancies, Nat Med, 20, 1472, 10.1038/nm.3733 · DOI · Paper page
- Zink, 2017, Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly, Blood, 130, 742, 10.1182/blood-2017-02-769869 · DOI · Paper page
- Steensma, 2015, Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes, Blood, 126, 9, 10.1182/blood-2015-03-631747 · DOI · Paper page
- Bick, 2020, Genetic interleukin 6 signaling deficiency attenuates cardiovascular risk in clonal hematopoiesis, Circulation, 141, 124, 10.1161/CIRCULATIONAHA.119.044362 · DOI · Paper page
- Sano, 2018, Tet2-mediated clonal hematopoiesis accelerates heart failure through a mechanism involving the IL-1β/NLRP3 inflammasome, J Am Coll Cardiol, 71, 875, 10.1016/j.jacc.2017.12.037 · DOI · Paper page
- Dorsheimer, 2019, Association of mutations contributing to clonal hematopoiesis with prognosis in chronic ischemic heart failure, JAMA Cardiol, 4, 25, 10.1001/jamacardio.2018.3965 · DOI · Paper page
- Cremer, 2020, Multiple somatic mutations for clonal hematopoiesis are associated with increased mortality in patients with chronic heart failure, Circ Genomic Precis Med, 13, 10.1161/CIRCGEN.120.003003 · DOI
- Poller, 2020, Hematopoiesis and cardiovascular disease, Circ Res, 126, 1061, 10.1161/CIRCRESAHA.120.315895 · DOI
- Fernández-Vázquez, 2020, Changes in causes of death and influence of therapeutic improvement over time in patients with heart failure and reduced ejection fraction, Rev Esp Cardiol, 73, 561, 10.1016/j.recesp.2019.09.012 · DOI
- Benjamin, 2019, Calling somatic SNVs and indels with Mutect2, bioRxiv, 861054
- Cook, 2019, Comorbid and inflammatory characteristics of genetic subtypes of clonal hematopoiesis, Blood Adv, 3, 2482, 10.1182/bloodadvances.2018024729 · DOI
- Sano, 2018, CRISPR-mediated gene editing to assess the roles of TET2 and DNMT3A in clonal hematopoiesis and cardiovascular disease, Circ Res, 123, 335, 10.1161/CIRCRESAHA.118.313225 · DOI · Paper page
- Khetarpal, 2019, Clonal hematopoiesis of indeterminate potential reshapes age-related CVD: JACC review topic of the week, J Am Coll Cardiol, 74, 578, 10.1016/j.jacc.2019.05.045 · DOI
- Fuster, 2018, Somatic mutations and clonal hematopoiesis: unexpected potential new drivers of age-related cardiovascular disease, Circ Res, 122, 523, 10.1161/CIRCRESAHA.117.312115 · DOI · Paper page
- Abplanalp, 2021, Clonal hematopoiesis-driver DNMT3A mutations alter immune cells in heart failure, Circ Res, 128, 216, 10.1161/CIRCRESAHA.120.317104 · DOI
- Fuster, 2020, TET2-loss-of-function-driven clonal hematopoiesis exacerbates experimental insulin resistance in aging and obesity, Cell Rep, 33, 108326, 10.1016/j.celrep.2020.108326 · DOI · Paper page
- Abplanalp, 2020, Association of clonal hematopoiesis of indeterminate potential with inflammatory gene expression in patients with severe degenerative aortic valve stenosis or chronic postischemic heart failure, JAMA Cardiol, 5, 1, 10.1001/jamacardio.2020.2468 · DOI · Paper page
- Tsutamoto, 1998, Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure, J Am Coll Cardiol, 31, 391, 10.1016/S0735-1097(97)00494-4 · DOI
- Pascual-Figal, 2019, The interleukin-1 axis and risk of death in patients with acutely decompensated heart failure, J Am Coll Cardiol, 73, 1016, 10.1016/j.jacc.2018.11.054 · DOI
- Everett, 2019, Anti-inflammatory therapy with canakinumab for the prevention of hospitalization for heart failure, Circulation, 139, 1289, 10.1161/CIRCULATIONAHA.118.038010 · DOI · Paper page
Cited by
Blockade of IL-6 signaling alleviates atherosclerosis in Tet2-deficient clonal hematopoiesis
Liu, W., Yalcinkaya, M., Maestre, I. F., Olszewska, M., Ampomah, P. B., Heimlich, J. B., Wang, R., Vela, P. S., Xiao, T., Bick, A. G., et al. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00281-3 · Cited by 93
Roadmap for alleviating the manifestations of ageing in the cardiovascular system
Liberale, L., Tual-Chalot, S., Sedej, S., Ministrini, S., Georgiopoulos, G., Grunewald, M., Bäck, M., Bochaton-Piallat, M.-L., Boon, R. A., Ramos, G. C., et al. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01130-5 · Cited by 59
Evans, M. A., Chavkin, N. W., Sano, S., Sun, H., Sardana, T., Ravi, R., Doviak, H., Wang, Y., Yura, Y., Polizio, A. H., et al. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1487867 · Cited by 4
Metadata
- Authors
- Pascual-Figal, D. A., Bayes-Genis, A., Díez-Díez, M., Hernández-Vicente, Á., Vázquez-Andrés, D., de la Barrera, J., Vazquez, E., Quintas, A., Zuriaga, M. A., Asensio-López, M. C., Dopazo, A., Sánchez-Cabo, F., & Fuster, J. J.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 77
- Issue
- 14
- Pages
- 1747-1759
- ISSN
- 0735-1097
- Cited by
- 221
- References
- 11
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review