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Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease

Fuster, José J., Walsh, Kenneth·2018·Circulation Research
DOI 10.1161/circresaha.117.312115PMC PMC5826570
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Abstract

Increasing evidence shows that conventional cardiovascular risk factors are incompletely predictive of cardiovascular disease, particularly in elderly individuals, suggesting that there may still be unidentified causal risk factors. Although the accumulation of somatic DNA mutations is a hallmark of aging, its relevance in cardiovascular disease or other age-related conditions has been, with the exception of cancer, largely unexplored. Here, we review recent clinical and preclinical studies that have identified acquired mutations in hematopoietic stem cells and subsequent clonal hematopoiesis as a new cardiovascular risk factor and a potential major driver of atherosclerosis. Understanding the mechanisms underlying the connection between somatic mutation-driven clonal hematopoiesis and cardiovascular disease will be highly relevant in the context of personalized medicine, as it may provide key information for the design of diagnostic, preventive, or therapeutic strategies tailored to the effects of specific somatic mutations.

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  1. 10.1016/S0140-6736(16)31012-1 · DOI · Paper page
  2. 10.1016/S0140-6736(08)60313-X · DOI
  3. 10.1001/jama.290.7.898 · DOI · Paper page
  4. 10.1016/j.jacc.2015.01.017 · DOI · Paper page
  5. 10.1161/CIRCULATIONAHA.114.014310 · DOI
  6. 10.1016/j.jacc.2015.12.056 · DOI
  7. 10.1016/j.jacc.2017.10.024 · DOI · Paper page
  8. 10.1093/eurheartj/ehw026 · DOI
  9. 10.1161/JAHA.116.003665 · DOI
  10. 10.1016/S0140-6736(07)61778-4 · DOI · Paper page
  11. 10.1056/NEJMoa1110874 · DOI
  12. 10.1001/jama.2016.16951 · DOI · Paper page
  13. 10.1038/nrg.2016.160 · DOI · Paper page
  14. 10.1056/NEJMra1105239 · DOI
  15. 10.1126/science.1237758 · DOI · Paper page
  16. 10.1038/nature21703 · DOI
  17. 10.1038/nrg.2016.145 · DOI
  18. 10.1016/j.gde.2014.04.002 · DOI
  19. 10.1182/blood.V83.4.931.931 · DOI · Paper page
  20. 10.1046/j.1365-2141.1997.2573078.x · DOI
  21. 10.1182/blood-2017-02-769869 · DOI · Paper page
  22. 10.1038/nm.3733 · DOI · Paper page
  23. 10.1038/ng.2413 · DOI · Paper page
  24. 10.1101/gr.162131.113 · DOI · Paper page
  25. 10.1182/blood-2015-03-631747 · DOI · Paper page
  26. 10.1038/leu.2017.181 · DOI
  27. 10.1038/ng.2700 · DOI · Paper page
  28. 10.1016/j.ajhg.2011.12.009 · DOI · Paper page
  29. 10.1038/ng.2270 · DOI · Paper page
  30. 10.1038/ng.2271 · DOI · Paper page
  31. 10.1038/ng.1009 · DOI · Paper page
  32. 10.1038/leu.2015.358 · DOI · Paper page
  33. 10.1182/blood-2009-07-230698 · DOI
  34. 10.1084/jem.20131141 · DOI
  35. 10.1182/blood-2013-05-500272 · DOI
  36. 10.1073/pnas.1112317108 · DOI · Paper page
  37. 10.1016/j.ccr.2011.06.003 · DOI · Paper page
  38. 10.1016/j.jns.2012.09.012 · DOI
  39. 10.1111/j.1538-7836.2007.02424.x · DOI
  40. 10.1002/ajh.23632 · DOI
  41. 10.1002/ajh.23874 · DOI
  42. 10.1182/blood-2011-11-394775 · DOI · Paper page
  43. 10.1182/blood-2009-12-259747 · DOI
  44. 10.1016/j.ccr.2010.05.015 · DOI
  45. 10.1182/blood-2009-04-215848 · DOI
  46. 10.1038/nature09586 · DOI · Paper page
  47. 10.1126/science.1210944 · DOI
  48. 10.1182/blood-2010-12-325241 · DOI · Paper page
  49. Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2000;7:273–281.
  50. 10.1002/eji.1830190207 · DOI
  51. 10.1128/MCB.13.10.6231 · DOI · Paper page
  52. 10.4049/jimmunol.139.6.1911 · DOI
  53. 10.4049/jimmunol.139.6.1902 · DOI
  54. 10.1084/jem.165.5.1316 · DOI
  55. 10.1056/NEJMoa1707914 · DOI · Paper page
  56. Ridker PM, MacFadyen JG, Everett BM, Libby P, Thuren T, Glynn RJ; CANTOS Trial Group. Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial [published online ahead of print November 13, 2017]. Lancet. doi: http://dx.doi.org/10.1016/S0140-6736(17)32814-3. http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32814-3/fulltext. · DOI
  57. 10.1161/ATVBAHA.117.310097 · DOI
  58. 10.1161/CIRCRESAHA.115.306656 · DOI · Paper page
  59. 10.1016/j.ahj.2013.03.018 · DOI · Paper page
  60. 10.4049/jimmunol.0802960 · DOI · Paper page
  61. 10.4049/jimmunol.1203229 · DOI
  62. 10.1073/pnas.1103803109 · DOI
  63. 10.1016/j.celrep.2017.09.018 · DOI
  64. 10.1038/ni.3464 · DOI · Paper page
  65. 10.1016/j.cmet.2010.06.008 · DOI
  66. 10.1016/S0140-6736(05)67785-9 · DOI
  67. 10.1111/j.1365-2141.2005.05858.x · DOI
  68. 10.3324/haematol.10634 · DOI
  69. 10.1016/j.exphem.2007.08.011 · DOI
  70. 10.1002/cncr.22663 · DOI
  71. 10.1038/sj.leu.2404854 · DOI
  72. 10.1182/blood-2006-12-064287 · DOI
  73. 10.1016/j.leukres.2008.06.006 · DOI
  74. 10.1111/j.1751-553X.2010.01275.x · DOI
  75. 10.1056/NEJMc1710381 · DOI
  76. 10.1084/jem.20131371 · DOI
  77. 10.1152/ajpcell.00026.2003 · DOI
  78. 10.1111/j.1365-2141.2010.08249.x · DOI · Paper page
  79. 10.1038/s41598-017-07923-0 · DOI
  80. 10.1016/j.ccr.2012.06.032 · DOI
  81. 10.1038/ncomms8307 · DOI · Paper page
  82. 10.1182/blood-2017-06-789669 · DOI
  83. 10.1016/j.jacc.2017.12.037 · DOI · Paper page
  84. 10.1182/blood-2015-06-652941 · DOI · Paper page
  85. 10.1016/j.stem.2017.07.010 · DOI · Paper page
  86. 10.1038/nrcardio.2014.9 · DOI
  87. 10.1016/j.stem.2016.06.007 · DOI
  88. 10.1161/CIRCRESAHA.114.304792 · DOI
  89. 10.1242/dev.060103 · DOI

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Metadata

Authors
Fuster, J. J., & Walsh, K.
Venue
Circulation Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2018-02-02
Volume
122
Issue
3
Pages
523-532
ISSN
  • 0009-7330
  • 1524-4571
DOI
10.1161/circresaha.117.312115
PMC
PMC5826570
Cited by
162
References
27
Language
en

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CoChat. (2026). Citation check: Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease. https://app.cochat.ai/papers/10.1161/circresaha.117.312115
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Fuster, J. J., & Walsh, K. (2018). Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease. Circulation Research. https://doi.org/10.1161/circresaha.117.312115