The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Canadian Spontaneous Coronary Artery Dissection Cohort Study
Open accessAbstract
Background Spontaneous coronary artery dissection (SCAD) is an important cause of myocardial infarction (MI) in young to middle-aged women.Objectives We aim to define the long-term natural history of SCAD.Methods We performed a multicenter, prospective, observational study of patients with nonatherosclerotic SCAD presenting acutely from 22 North American centers. We recorded baseline demographics, in-hospital characteristics, precipitating and predisposing conditions, angiographic features (adjudicated), in-hospital and 3-year major adverse cardiovascular events (MACE). Cox regression multivariable analysis was performed.Results We prospectively enrolled 750 consecutive patients with SCAD from June 2014 to June 2018. Mean age was 51.7 ± 10.5 years, 88.5% were women (55.0% postmenopausal); 31.3% presented with ST-segment elevation myocardial infarction, and 68.3% with non-ST-segment elevation myocardial infarction. Precipitating emotional stressor was reported in 50.3%, and physical stressor in 28.9%. Predisposing conditions included fibromuscular dysplasia in 42.9% (56.4% in those with complete screening), peripartum state 4.5%, and genetic disorders 1.6%. Most patients were treated conservatively (84.3%); 14.1% underwent percutaneous coronary intervention (PCI), 0.7% coronary artery bypass graft. At 3.0-year median follow-up, mortality was 0.8%, recurrent MI 9.9% (extension of previous SCAD 3.5%, de novo recurrent SCAD 2.4%, iatrogenic dissection 1.9%), with overall MACE 14.0%. Presence of genetic disorders, peripartum SCAD, and extracoronary fibromuscular dysplasia were independent predictors of 3-year MACE. Patients who underwent PCI at index hospitalization had similar postdischarge MACE compared with no PCI. At 3 years, 80.0% remained on aspirin and 73.5% on beta-blockade.Conclusions Long-term mortality and de novo recurrent SCAD was low in our contemporary large SCAD cohort that included low revascularization rate and high use of beta-blockade and aspirin. Genetic disorders, extracoronary fibromuscular dysplasia, and peripartum SCAD were independent predictors of long-term MACE.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A Global Measure of Perceived Stress
Cohen, S., Kamarck, T., & Mermelstein, R. (1983) · Journal of Health and Social Behavior · doi:10.2307/2136404 · Cited by 32,807
Third universal definition of myocardial infarction
Thygesen, K. A., Alpert, J. S., Jaffe, A. S., Simoons, M. L., Chaitman, B. R., White, H. D., the Writing Group on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, Authors/Task Force Members Chairpersons, Thygesen, K., Alpert, J. S., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs184 · Cited by 3,095
Hayes, S. N., Kim, E., Saw, J., Adlam, D., Arslanian‐Engoren, C., Economy, K. E., Ganesh, S. K., Gulati, R., Lindsay, M. E., Mieres, J. H., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000564 · Cited by 1,346
Self-citationSpontaneous Coronary Artery Dissection
Saw, J., Aymong, E. D., Sedlak, T., Buller, C. E. H., Starovoytov, A., Ricci, D. R., Robinson, S. S., Vuurmans, T., Gao, M., Humphries, K. H., et al. (2014) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.114.001760 · Cited by 783
Self-citationAdlam, D., Alfonso, F., Maas, A. H. E. M., Vrints, C. J., Al-Hussaini, A., Bueno, H., Capranzano, P., Gevaert, S., Hoole, S. P., Johnson, T., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy080 · Cited by 686
Spontaneous Coronary Artery Dissection
Saw, J., Humphries, K. H., Aymong, E. D., Sedlak, T., Prakash, R., Starovoytov, A., & Mancini, G. B. J. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.06.053 · Cited by 619
Self-citationContemporary Review on Spontaneous Coronary Artery Dissection
Saw, J., Mancini, G. B. J., & Humphries, K. H. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.05.034 · Cited by 585
Self-citationCoronary angiogram classification of spontaneous coronary artery dissection
Saw, J. (2013) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.25293 · Cited by 476
Self-citationFibromuscular Dysplasia: State of the Science and Critical Unanswered Questions
Olin, J. W., Gornik, H. L., Bacharach, J. M., Biller, J., Fine, L. J., Gray, B. H., Gray, W. A., Gupta, R. G., Hamburg, N. M., Katzen, B. T., et al. (2014) · Circulation · doi:10.1161/01.cir.0000442577.96802.8c · Cited by 473
Canadian spontaneous coronary artery dissection cohort study: in-hospital and 30-day outcomes
Saw, J., Starovoytov, A., Humphries, K. H., Sheth, T., So, D. Y. F., Minhas, K., Brass, N. S., Lavoie, A., Bishop, H., Lavi, S., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz007 · Cited by 440
Self-citationSpontaneous Coronary Artery Dissection
Saw, J., Ricci, D. R., Starovoytov, A., Fox, R., & Buller, C. E. H. (2012) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2012.08.017 · Cited by 393
Self-citationNakashima, T., Noguchi, T., Haruta, S., Yamamoto, Y., Oshima, S., Nakao, K., Taniguchi, Y., Yamaguchi, J., Tsuchihashi, K., Seki, A., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.01.188 · Cited by 356
Nonatherosclerotic Coronary Artery Disease in Young Women
Saw, J., Aymong, E. D., Mancini, G. B. J., Sedlak, T., Starovoytov, A., & Ricci, D. R. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.01.011 · Cited by 282
Self-citationSaw, J., Mancini, G. B. J., Humphries, K. H., Fung, A., Boone, R., Starovoytov, A., & Aymong, E. D. (2015) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.26022 · Cited by 200
Self-citationPrasad, M., Tweet, M. S., Hayes, S. N., Leng, S., Liang, J. J., Eleid, M. F., Gulati, R., & Vrtiska, T. J. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2015.03.011 · Cited by 198
Pregnancy-Related Spontaneous Coronary Artery Dissection
Vijayaraghavan, R., Verma, S., Gupta, N., & Saw, J. (2014) · Circulation · doi:10.1161/circulationaha.114.011422 · Cited by 174
Self-citationChou, A. Y., Prakash, R., Rajala, J., Birnie, T., Isserow, S., Taylor, C. M., Ignaszewski, A. P., Chan, S., Starovoytov, A., & Saw, J. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.01.009 · Cited by 139
Self-citationMahmoud, A. N., Taduru, S. S., Mentias, A. G., Mahtta, D., Barakat, A. F., Saad, M. S., Elgendy, A. Y., Mojadidi, M. K., Omer, M. A., Abuzaid, A., et al. (2017) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2017.08.016 · Cited by 124
Self-citationSaw, J. (2017) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.117.005119 · Cited by 41
Self-citationCharacteristics of extension and de novo recurrent spontaneous coronary artery dissection
Main, A., Prakash, R., Starovoytov, A., et al. (2017) · EuroIntervention · doi:10.4244/eij-d-17-00264 · Cited by 41
Self-citation456 Characteristics and Clinical Outcomes in Patients With Spontaneous Coronary Artery Dissection
Tan, C., Dagan, M., Stehli, J., Zaman, S. J., Duffy, S. J., & Kaye, D. M. (2020) · Heart Lung and Circulation · doi:10.1016/j.hlc.2020.09.463 · Cited by 13
Flagged first, then by citations
Research works printed but not linked: 1
- Alderman, 1992, The angiographic definitions of the Bypass Angioplasty Revascularization Investigation, Coronary Artery Dis, 3, 1189
Cited by
Sorted by citations
Vine, D., Ghosh, M., Wang, T., & Bakal, J. (2024) · CJC Open · doi:10.1016/j.cjco.2023.12.010 · Cited by 53
“118 In a Danish cohort, CVD incidence, including hypertension, occurred at a median age of 35 and 36 years in those with PCOS and in non-PCOS controls, respectively, and > 95% of those diagnosed with CVD were aged 50 years.”
BackgroundVascular Diseases in Women: Do Women Suffer from Them Differently?
Farkas, K., Stanek, A., Zbinden, S., Borea, B., Ciurica, S., Moore, V., Maguire, P., Abola, M. T. B., Alajar, E. B., Marcoccia, A., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13041108 · Cited by 13
Metadata
- Authors
- Saw, J., Starovoytov, A., Aymong, E., Inohara, T., Alfadhel, M., McAlister, C., Samuel, R., Grewal, T., Parolis, J. A., Sheth, T., So, D., Minhas, K., Brass, N., Lavoie, A., Bishop, H., Lavi, S., Pearce, C., Renner, S., Madan, M., Welsh, R. C., McGrath, B. M., Vijayaraghavan, R., Har, B., Ibrahim, R., Chaudhary, P., Ganesh, S. K., Graham, J., Matteau, A., Martucci, G., Ko, D. T., Humphries, K., & Mancini, G. J.
- Affiliations
- Vancouver General Hospital (CA)
- St. Paul's Hospital (CA)
- Hamilton General Hospital (CA)
- University of Ottawa (CA)
- St. Boniface Hospital (CA)
- Royal Alexandra Hospital (CA)
- University of Saskatchewan (CA)
- London Health Sciences Centre (CA)
- Royal University Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- University of Alberta (CA)
- Scarborough Health Network (CA)
- University of Michigan (US)
- St. Michael's Hospital (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- McGill University Health Centre (CA)
- Corresponding author
- Saw, Jacqueline
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2022-10
- Volume
- 80
- Issue
- 17
- Pages
- 1585-1597
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W4306649371
- Cited by
- 155
- References
- 21
- Citations by year
- 2026: 45 · 2025: 35 · 2024: 42 · 2023: 29 · 2022: 2
- FWCI
- 18.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Sanofi
- Heart and Stroke Foundation of Canada
- University of Michigan
- Boston Scientific Corporation
- Sunovion
- University of Toronto
- Servier
- HLS Therapeutics
- National Institutes of Health
- Abbott Vascular
- Canadian Institutes of Health Research
- Japan Society for the Promotion of Science (21K08115)
- National Heart, Lung, and Blood Institute (HL139672, R01HL139672)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Issues in Pregnancy
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Takotsubo Cardiomyopathy and Associated Phenomena
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- spontaneous coronary artery dissection, major adverse cardiovascular events, reinfarction, fibromuscular dysplasia, genetic disorders, percutaneous coronary intervention, beta-adrenergic blockade, aspirin, women, ST-elevation myocardial infarction, non-ST-elevation myocardial infarction
- MeSH terms
- Non-ST Elevated Myocardial Infarction, Adult, Aftercare, Aspirin, Canada, Coronary Vessel Anomalies, Coronary Vessels, Female, Fibromuscular Dysplasia, Humans, Male, Middle Aged, Myocardial Infarction, Patient Discharge, Prospective Studies, Vascular Diseases, Cohort Studies, Coronary Angiography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
