Omega-3 Fatty Acids and Risk for Atrial Fibrillation
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In the REDUCE-IT trial, high-dose EPA (4,000 mg/d) reduced relative risk of stroke by 28% despite increasing relative risk of AF by 35%.
“Similarly, in the REDUCE-IT trial69, 125, which was comprised of high-CVD risk patients, high-dose EPA (4,000 mg/d) reduced relative risk of stroke by 28% despite increasing relative risk of AF by 35%126.”
From Effects of Omega-3 Fatty Acid Treatment on Risk for Atrial Fibrillation: An Updated Meta-Analysis of 35 Trials including 114 592 Individuals (2026) · cites this paper as [126]
In REDUCE-IT, participants in the EPA arm who developed AF experienced lower risks of stroke and MACE compared to control participants who developed AF.
“Even those in the EPA arm of the REDUCE-IT study who developed AF experienced lower risks of stroke and MACE compared to those in the control group who developed AF126.”
From Effects of Omega-3 Fatty Acid Treatment on Risk for Atrial Fibrillation: An Updated Meta-Analysis of 35 Trials including 114 592 Individuals (2026) · cites this paper as [126]
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References 20 · Cited by 10
- Authors
- Ballantyne, C. M., & Jia, X.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Ballantyne, Christie M.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2023-07
- Volume
- 82
- Issue
- 4
- Pages
- 350-352
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W4384500980
- Cited by
- 10
- References
- 20
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 1 · 2023: 3
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons-TMC (Texas Medical Center) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- omega-3 fatty acids, atrial fibrillation, cardiovascular risk, antiarrhythmic effect
- MeSH terms
- Animals, Atrial Fibrillation, Fishes, Fatty Acids, Omega-3
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