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Prenatal prediction of infant atopy by maternal but not paternal total IgE levels

Liu, Chieh-An, Wang, Chih-Lu, Chuang, Hau, Ou, Chia-Yu, Hsu, Te-Yao, Yang, Kuender D·2003·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2003.08.030
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Abstract

Background The atopic history of parents has long been used to predict infant atopy. However, bias from questionnaires of allergic history are also frequently suspected, because a large number of vasomotor rhinitis, intrinsic asthma, and seborrheic dermatitis cases are probably misinterpreted to be atopic diseases. Objective We attempted to identify a risk factor other than parental atopic history to predict elevated infant IgE levels and infant atopy. Methods A total of 655 core families were prenatally recruited, and finally 545 families completed the study for the prospective analysis of infant atopy at 6 months of age. Atopic history and blood samples of parents were collected in the third trimester during pregnancy. Cord blood (CB) was collected immediately after birth. Infant blood samples and history of infant eczema were collected in the 6-month physical checkup clinic. Blood total IgE and specific IgE levels were determined by use of the Pharmacia CAP system. Results In univariate analysis, maternal, but not paternal, atopic history correlated with elevated CB IgE levels and the occurrence of infant eczema. Elevated maternal, but not paternal, total IgE levels (>150 KU/L) significantly correlated with increases of CB IgE levels (median, 0.54 vs 0.17 KU/L, P Conclusions The maternal, but not paternal, total IgE level correlates with elevated infant IgE levels and infant atopy. This provides a high specificity (83%) and a sensitivity of 34% for prediction of infant ato…

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Metadata

Authors
Liu, C.-A., Wang, C.-L., Chuang, H., Ou, C.-Y., Hsu, T.-Y., & Yang, K. D.
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2003-11
Volume
112
Issue
5
Pages
899-904
ISSN
0091-6749
DOI
10.1016/j.jaci.2003.08.030
Cited by
132
References
1
Language
en
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CoChat. (2026). Citation check: Prenatal prediction of infant atopy by maternal but not paternal total IgE levels. https://app.cochat.ai/papers/10.1016/j.jaci.2003.08.030
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Liu, C.-A., Wang, C.-L., Chuang, H., Ou, C.-Y., Hsu, T.-Y., & Yang, K. D. (2003). Prenatal prediction of infant atopy by maternal but not paternal total IgE levels. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2003.08.030