How do topical nasal corticosteroids improve sleep and daytime somnolence in allergic rhinitis?
Open accessAbstract
Therapy for rhinitis improves sleep quality and symptoms of daytime sleepiness. This improvement with therapy may be secondary to anti-inflammatory effects, leading to a reduction of inflammatory mediators, or to a mechanical reduction of congestion directly leading to improvement in sleep disturbance. We combined our data from 3 placebo-controlled studies of intranasal corticosteroids in patients with perennial rhinitis to determine whether a correlation between the reduction of congestion and improved sleep and daytime somnolence existed. The pooled data of budesonide, flunisolide, and fluticasone demonstrated significantly decreased nasal congestion, sleep problems, and sleepiness in treated patients. The data demonstrated a correlation between a reduction in nasal congestion and an improvement of sleep (P < .01) and daytime somnolence (P = .01). Thus, topical intranasal corticosteroids should be used to decrease nasal congestion and to improve sleep and daytime somnolence in patients manifesting these symptoms.
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Nasal obstruction, allergic rhinitis, and chronic sinusitis have repeatedly been demonstrated as significant risk factors for habitual snoring, chronic excessive daytime sleepiness, and sleep-disordered breathing.
“Nasal obstruction, AR, and chronic sinusitis have repeatedly been demonstrated as significant risk factors for habitual snoring, chronic excessive daytime sleepiness, and SDB.”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [891]
The paper’s discussion of Young et al. (section labeled Abstract; page unavailable) reports that chronic rhinitis symptoms were associated with daytime sleepiness and that nasal obstruction may be a risk factor for sleep-disordered breathing. It does not address chronic sinusitis or habitual snoring, and it describes the sleep-disordered-breathing finding as suggestive rather than establishing all three conditions as repeatedly demonstrated significant risk factors. (LLM, conf=0.86)
Experimental — accuracy not yet measuredIntranasal corticosteroids have been shown to improve congestion and daytime somnolence in patients with perennial rhinitis.
“Intranasal corticosteroids have been shown to improve congestion and daytime somnolence in patients with perennial rhinitis.”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [891]
Pooled data from three double-blind crossover randomized controlled trials of budesonide, flunisolide, and fluticasone demonstrated significantly decreased nasal congestion and sleepiness in treated patients.
“Pooled data from three double-blind crossover RCTs of budesonide, flunisolide, and fluticasone demonstrated significantly decreased nasal congestion and sleepiness in treated patients.”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [891]
Intranasal corticosteroids have been shown to improve nasal congestion, daytime somnolence, and sleep quality.
“INCS have been shown to improve nasal congestion, daytime somnolence, and sleep quality.2029”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [2029]
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- Authors
- Craig, T. J., Hanks, C. D., & Fisher, L. H.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Craig, Timothy J.
- ORCID
- Craig, Timothy J.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 116
- Issue
- 6
- Pages
- 1264-1266
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2047875483
- Semantic Scholar
- 86dc4d59fe3e9d2234e31c2fefba2c791b412cb8
- Cited by
- 69
- References
- 15
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2016: 2 · 2014: 4 · 2013: 8 · 2012: 7
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Genentech
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Surgery › Nasal Surgery and Airway Studies
- Keywords
- allergic rhinitis, intranasal corticosteroids, sleep quality, daytime somnolence, nasal congestion, budesonide, flunisolide, fluticasone, perennial rhinitis, anti-inflammatory activity
- MeSH terms
- Administration, Intranasal, Adolescent, Adrenal Cortex Hormones, Adult, Aged, Double-Blind Method, Rhinitis, Allergic, Seasonal, Humans, Disorders of Excessive Somnolence, Middle Aged, Rhinitis, Allergic, Perennial, Sleep, Cross-Over Studies
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