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Cited by 277

The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.

Severe asthma in adults: What are the important questions?

Open access
Chanez, Pascal, Wenzel, Sally E., Anderson, Gary P., Anto, Josep M., Bel, Elisabeth H., Boulet, Louis-Philippe, Brightling, Christopher E., Busse, William W., Castro, Mario, Dahlen, Babro, Dahlen, Sven Erik, Fabbri, Leo M., Holgate, Stephen T., Humbert, Marc, Gaga, Mina, Joos, Guy F., Levy, Bruce, Rabe, Klaus F., Sterk, Peter J., Wilson, Susan J., Vachier, Isabelle·2007·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2006.11.702
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Abstract

The term severe refractory asthma (SRA) in adults applies to patients who remain difficult to control despite extensive re-evaluation of diagnosis and management following an observational period of at least 6 months by a specialist. Factors that influence asthma control should be recognized and adequately addressed prior to confirming the diagnosis of SRA. This report presents statements according to the literature defining SRA in order address the important questions. Phenotyping SRA will improve our understanding of mechanisms, natural history, and prognosis. Female gender, obesity, and smoking are associated with SRA. Atopy is less frequent in SRA, but occupational sensitizers are common inducers of new-onset SRA. Viruses contribute to severe exacerbations and can persist in the airways for long periods. Inflammatory cells are in the airways of the majority of patients with SRA and persist despite steroid therapy. The T(H)2 immune process alone is inadequate to explain SRA. Reduced responsiveness to corticosteroids is common, and epithelial cell and smooth muscle abnormalities are found, contributing to airway narrowing. Large and small airway wall thickening is observed, but parenchymal abnormalities may influence airway limitation. Inhaled corticosteroids and bronchodilators are the mainstay of treatment, but patients with SRA remain uncontrolled, indicating a need for new therapies.

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Metadata

Authors
Chanez, P., Wenzel, S. E., Anderson, G. P., Anto, J. M., Bel, E. H., Boulet, L.-P., Brightling, C. E., Busse, W. W., Castro, M., Dahlen, B., Dahlen, S. E., Fabbri, L. M., Holgate, S. T., Humbert, M., Gaga, M., Joos, G. F., Levy, B., Rabe, K. F., Sterk, P. J., Wilson, S. J., & Vachier, I.
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2007-06
Volume
119
Issue
6
Pages
1337-1348
ISSN
0091-6749 (ISSN-L)
DOI
10.1016/j.jaci.2006.11.702
OpenAlex
W2006174105
Cited by
277
References
111
FWCI
18.19
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Severe asthma in adults: What are the important questions? https://app.cochat.ai/papers/10.1016/j.jaci.2006.11.702
The paper
Chanez, P., Wenzel, S. E., Anderson, G. P., Anto, J. M., Bel, E. H., Boulet, L.-P., Brightling, C. E., Busse, W. W., Castro, M., Dahlen, B., Dahlen, S. E., Fabbri, L. M., Holgate, S. T., Humbert, M., Gaga, M., Joos, G. F., Levy, B., Rabe, K. F., Sterk, P. J., . . . Vachier, I. (2007). Severe asthma in adults: What are the important questions? Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2006.11.702

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.