Cited by 83Allergic Rhinitis and SensitizationAsthma and respiratory diseasesFood Allergy and Anaphylaxis Research

Allergen skin tests and free IgE levels during reduction and cessation of omalizumab therapy

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Corren, Jonathan, Shapiro, Gail, Reimann, James, Deniz, Yamo, Wong, Dennis, Adelman, Daniel, Togias, Alkis·2008·Journal of Allergy and Clinical Immunology

Abstract

Background The recombinant humanized anti-IgE antibody omalizumab rapidly reduces serum free IgE concentrations and alleviates allergic airway disease. It is not known whether stopping or reducing the dose of omalizumab maintains adequate suppression of free IgE levels and IgE-mediated mast cell activation.Objective To determine the effects of omalizumab on serum free IgE and immediate allergen skin test reactivity during initial therapy followed by treatment reduction and cessation.Methods Forty patients with perennial allergic rhinitis were randomized to receive 0.015 or 0.030 mg/kg/IU/mL open-label intravenous omalizumab every 2 weeks for 28 weeks, followed by 0.0015 or 0.0050 mg/kg/IU/mL every 2 weeks for 18 weeks. Serum free IgE levels were measured and titrated dust mite allergen skin tests conducted throughout.Results At day 98, serum free IgE concentrations were decreased by 96% to 99%, and wheal-and-flare reactions to skin tests were markedly suppressed. After reduced omalizumab doses (day 322), serum free IgE and allergen skin test reactivity increased significantly. On complete discontinuation of therapy (day 378), serum free IgE levels and skin test reactivity returned to baseline levels. Patients with lower initial levels of IgE had significantly less suppression of skin test reactivity.Conclusion Omalizumab reduced serum free IgE and immediate skin test reactivity to allergen during initial, high-dose administration. These effects were not fully maintained during dose reduction and returned to baseline after cessation of chronic treatment.

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Crossref · 10.1016/j.jaci.2007.11.026

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  • Omalizumab suppresses skin test reactivity in tandem with dramatic reductions in serum free IgE, and allergy skin test responses return to normal within 8 weeks of discontinuation.

    “Omalizumab appears to suppress skin test reactivity in tandem with dramatic reductions in serum free IgE, and allergy skin test responses return to normal within 8 weeks of discontinuation.875”

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  1. Hochhaus G, Brookman L, Fox H, Johnson C, Matthews J, Ren S, et al. Pharma- codynamics of omalizumab: implications for optimized dosing strategies and clin- ical efficacy in the treatment of asthma. Curr Med Res Opin 2003;19:491-8.

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Authors
Corren, J., Shapiro, G., Reimann, J., Deniz, Y., Wong, D., Adelman, D., & Togias, A.
Affiliations
  • Genentech (US)
  • Pharmacyclics (United States) (US)
  • Johns Hopkins University (US)
Corresponding author
Corren, Jonathan
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2008-02
Volume
121
Issue
2
Pages
506-511
ISSN
0091-6749 (ISSN-L)
OpenAlex
W1977639139
Cited by
83
References
19
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 3 · 2012: 2
FWCI
4.11
Type
journal article
Language
en
Open access
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Amgen
  • AstraZeneca
  • GlaxoSmithKline
  • Genentech
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Keywords
omalizumab, perennial allergic rhinitis, anti-IgE therapy, treatment dose reduction, treatment discontinuation, house dust mite allergens, wheal and flare, IgE-mediated mast cell activation
MeSH terms
Omalizumab, Adult, Antibodies, Anti-Idiotypic, Antibodies, Monoclonal, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Humans, Immunoglobulin E, Injections, Intravenous, Male, Rhinitis, Allergic, Perennial, Skin Tests, Anti-Allergic Agents, Antigens, Dermatophagoides, Antibodies, Monoclonal, Humanized

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