The natural history of soy allergy
Open accessAbstract
Background Soy allergy is very common, affecting approximately 0.4% of children. It is generally thought that the majority of children with soy allergy develop tolerance in early childhood; however, this has not been examined in a large cohort with soy allergy.Objective We sought to describe the natural history of soy allergy and identify predictors of oral tolerance/outgrowing soy allergy.Methods The records of patients with soy allergy seen in a tertiary referral clinic were reviewed. Data collected included soy allergy-related symptoms, history of other food allergies and atopic diseases, soy-specific IgE levels, peanut-specific IgE levels, and food challenge results.Results One hundred thirty-three patients were studied (96 male and 37 female patients). Eighty-five (64%) had asthma, 95 (71%) had allergic rhinitis, and 108 (85%) had atopic dermatitis. Eighty-eight percent had concomitant peanut allergy. The median age at the initial visit was 1 year (range, 2 months to 17.5 years); the median duration of follow-up was 5 years (range, 1-19 years). Kaplan-Meier analysis predicted resolution of soy allergy in 25% by age 4 years, 45% by age 6 years, and 69% by age 10 years. By age 6 years, 59% of children with a peak soy IgE level of less than 5 kU/L, 53% of children with a peak s-IgE level of 5 to 9.9 kU/L, 45% of children with a peak s-IgE level of 10 to 49.9 kU/L, and 18% of children with a peak s-IgE level of greater than 50 kU/L had outgrown soy allergy (P < .01 for trend).Conclusions In this referral population approximately 50% of children with soy allergy outgrew their allergy by age 7 years. Absolute soy IgE levels were useful predictors of outgrowing soy allergy.
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A wealth of evidence exists to demonstrate soy's value as part of a healthy and varied diet.
“Overall, a wealth of evidence exists to demonstrate soy’s value as part of a healthy and varied diet [169].”
From Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function (2020) · cites this paper as [169]
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Cites
Burks, A. W., James, J. M., & Eigenmann, P. (1951) · Cited by 2,573 · see citing works
Utility of food-specific IgE concentrations in predicting symptomatic food allergy
Sampson, H. A. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.114708 · Cited by 1,362 · see citing works
Sampson, H. A., & Ho, D. G. (1997) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(97)70133-7 · Cited by 1,059 · see citing works
The natural history of IgE-mediated cow's milk allergy
Skripak, J. M., Matsui, E. C., Mudd, K., & Wood, R. A. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.08.023 · Cited by 794 · see citing works
Self-citationFood hypersensitivity and atopic dermatitis: Evaluation of 113 patients
Sampson, H. A., & McCaskill, C. C. (1985) · The Journal of Pediatrics · doi:10.1016/s0022-3476(85)80390-5 · Cited by 727 · see citing works
Sicherer, S. H., & Sampson, H. A. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.05.048 · Cited by 647 · see citing works
The natural history of egg allergy
Savage, J. H., Matsui, E. C., Skripak, J. M., & Wood, R. A. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.09.040 · Cited by 591 · see citing works
Self-citationNatural history of food hypersensitivity in children with atopic dermatitis
Sampson, H. A., & Scanlon, S. M. (1989) · The Journal of Pediatrics · doi:10.1016/s0022-3476(89)80323-3 · Cited by 363 · see citing works
The relationship of allergen-specific IgE levels and oral food challenge outcome
Perry, T. T., Matsui, E. C., Conover-Walker, M. K., & Wood, R. A. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.04.009 · Cited by 337 · see citing works
Self-citationThe Natural History of Food Allergy
Wood, R. A. (2003) · PEDIATRICS · doi:10.1542/peds.111.s3.1631 · Cited by 283 · see citing works
Self-citationThe natural history of wheat allergy
Keet, C. A., Matsui, E. C., Dhillon, G., et al. (2009) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)60513-3 · Cited by 225 · see citing works
Self-citationKlemola, T., Vanto, T., Juntunen‐Backman, K., Kalimo, K., Korpela, R., & Varjonen, E. (2002) · The Journal of Pediatrics · doi:10.1067/mpd.2002.121935 · Cited by 202 · see citing works
Ballmer-Weber, B. K., & Vieths, S. (2008) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e3282ffb157 · Cited by 75 · see citing works
Usefulness of Wheat and Soybean Specific IgE Antibody Titers for the Diagnosis of Food Allergy
Komata, T., Söderström, L., Borres, M. P., et al. (2009) · Allergology International · doi:10.2332/allergolint.09-oa-0096 · Cited by 53 · see citing works
Soy allergy is not common in atopic children: a multicenter study
Bruno, G., Giampietro, P. G., Guercio, M. J. D., Gallia, P. L., Giovannini, L., Lovati, C., Paolucci, P., Quaglio, L., Zoratto, E., & Businco, L. (1997) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.1997.tb00159.x · Cited by 50 · see citing works
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Research works printed but not linked: 1
- Sampson HA, McCaskill CM. Food hypersensitivity in atopic dermatitis: evalua- tion of 113 patients. J Pediatr 1985;107:669-75.
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Food allergy: A practice parameter update—2014
Sampson, H. A., Aceves, S., Bock, S. A., James, J., Jones, S., Lang, D., Nadeau, K., Nowak-Wegrzyn, A., Oppenheimer, J., Perry, T. T., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.05.013 · Cited by 845 · see citing works
Self-citationPlant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function
Hertzler, S. R., Lieblein-Boff, J. C., Weiler, M., & Allgeier, C. (2020) · Nutrients · doi:10.3390/nu12123704 · Cited by 594 · see citing works
- Authors
- Savage, J. H., Kaeding, A. J., Matsui, E. C., & Wood, R. A.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Wood, Robert A.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 125
- Issue
- 3
- Pages
- 683-686
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W1970697032
- Cited by
- 226
- References
- 15
- Citations by year
- 2026: 3 · 2025: 14 · 2024: 6 · 2023: 14 · 2022: 22 · 2021: 14 · 2020: 13 · 2019: 14 · 2018: 7 · 2017: 16 · 2016: 12 · 2015: 18 · 2014: 14 · 2013: 21 · 2012: 16
- FWCI
- 13.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Surgery › Eosinophilic Esophagitis
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Keywords
- soy allergy, natural history (disease), oral tolerance, peanut allergy, food allergy, atopic diseases, children
- MeSH terms
- Adolescent, Child, Child, Preschool, Female, Food Hypersensitivity, Humans, Immunoglobulin E, Infant, Male, Glycine max, Age of Onset, Young Adult
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