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Cited by 19

The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.

α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin

Ohmatsu, Hanako, Kadono, Takafumi, Sugaya, Makoto, Tomita, Manabu, Kai, Hiromichi, Miyagaki, Tomomitsu, Saeki, Hidehisa, Tamaki, Kunihiko, Steeber, Douglas A., Tedder, Thomas F., Sato, Shinichi·2010·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2010.08.048
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Abstract

Background β7 Integrin, a cell adhesion molecule, is present in the form of α4β7 integrin or αEβ7 integrin. α4β7 Integrin is expressed on most leucocytes and is essential for their migration to gut-associated lymphoid tissues by interacting with its primary ligand, mucosal addressin cell adhesion molecule-1, which is preferentially expressed in gut-associated lymphoid tissues. Although the importance of α4β7 integrin in intestinal inflammation has been established, its role in cutaneous inflammation remains to be elucidated. Objective We sought to investigate the role of β7 integrin in cutaneous inflammation. Methods We used a murine contact hypersensitivity model and examined the role of β7 integrin by using β7 integrin-deficient and αE integrin-deficient mice. Results β7 Integrin-deficient mice, not αE integrin-deficient mice, are defective in contact hypersensitivity responses. β7 Integrin deficiency does not affect irritant contact dermatitis. The distribution, migration, and function of antigen presenting cells from β7 integrin-deficient mice are comparable to those from wild-type mice. Moreover, sensitized β7 integrin-deficient T cells are able to respond to antigen stimuli in vitro and elicit contact hypersensitivity responses when directly injected into the skin. However, they are defective in reaching the skin under inflammatory conditions, resulting in reduced contact hypersensitivity responses when intravenously injected. Furthermore, intraperitoneal injection of a…

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Crossref · 10.1016/j.jaci.2010.08.048

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Metadata

Authors
Ohmatsu, H., Kadono, T., Sugaya, M., Tomita, M., Kai, H., Miyagaki, T., Saeki, H., Tamaki, K., Steeber, D. A., Tedder, T. F., & Sato, S.
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2010-12
Volume
126
Issue
6
Pages
1267-1276
ISSN
0091-6749
DOI
10.1016/j.jaci.2010.08.048
Cited by
19
References
64
Language
en
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)
Funders
Ministry of Education, Culture, Sports, Science and Technology

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.