Effects of omalizumab on changes in pulmonary function induced by controlled cat room challenge
Open accessAbstract
Background Environmental exposure to cat allergen is common, and sensitization to cat allergens is strongly associated with asthma.Objective We sought to examine the efficacy of omalizumab in preventing acute bronchoconstriction induced by environmental exposure to cat allergen.Methods Patients with a history of cat allergen-induced asthma were randomized to treatment with omalizumab or placebo and exposed to cat allergen in a controlled chamber for up to 1 hour at baseline and after 16 weeks of treatment. The primary efficacy outcome was area under the curve for percentage decrease from prechallenge FEV(1) at week 16 for omalizumab-treated versus placebo-treated patients. FEV(1) was recorded before and every 10 minutes during the 1-hour challenge. Chest, nasal, and ocular symptoms were also monitored during cat chamber exposure as secondary end points.Results The area under the curve for percentage decrease in FEV(1) was 15.2% per hour for omalizumab-treated patients (n = 32) and 27.3% per hour for placebo-treated patients (n = 33), reflecting 44% less reduction in FEV(1) and a treatment difference of -12.1% per hour (P = .0009; 95% CI, -19.0 to -5.2). Compared with placebo-treated patients, omalizumab-treated patients were also able to tolerate longer allergen exposure (P = .0006) and demonstrated significant reductions from prechallenge values in their chest symptom score (P < .0001) and nasal-ocular symptom score (P = .0002).Conclusions The severity of acute airway reactions and symptoms caused by controlled cat room exposure to allergens was significantly reduced by treatment with omalizumab.
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Numerous randomized, placebo-controlled clinical trials using allergen challenge chambers have tested the efficacy of drugs with immediate therapeutic activity, such as antihistamines, or with prophylactic therapeutic potential, such as topical steroids, novel anti-inflammatory compounds, or probiotics.
“In this respect, numerous randomized, placebo-controlled clinical trials have been conducted using parallel-group or crossover designs in order to test the efficacy of drugs with immediate therapeutic activity, such as antihistamines,1050-1053 or with prophylactic therapeutic potential, such as topical steroids,1054-1056 novel anti-inflammatory compounds,1057-1060 or probiotics.1061”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [1058]
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- Authors
- Corren, J., Wood, R. A., Patel, D., Zhu, J., Yegin, A., Dhillon, G., & Fish, J. E.
- Affiliations
- University of California, Los Angeles (US)
- Johns Hopkins University (US)
- Genentech (US)
- Corresponding author
- Corren, Jonathan
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 127
- Issue
- 2
- Pages
- 398-405
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2017731663
- Cited by
- 38
- References
- 29
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 4
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Food Allergy and Anaphylaxis Network
- National Institutes of Health
- Genentech
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- omalizumab, cat allergen, allergic asthma, bronchoconstriction, allergen challenge, FEV1, anti-IgE therapy, airway hyperresponsiveness, allergen tolerance, chest symptoms
- MeSH terms
- Omalizumab, Adult, Allergens, Animals, Antibodies, Anti-Idiotypic, Antibodies, Monoclonal, Asthma, Cats, Female, Forced Expiratory Volume, Glycoproteins, Humans, Male, Middle Aged, Bronchoconstriction, Anti-Allergic Agents, Antibodies, Monoclonal, Humanized
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