CoChat
Sign Up
Cited by 124

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Crucial role for autophagy in degranulation of mast cells

Ushio, Hiroko, Ueno, Takashi, Kojima, Yuko, Komatsu, Masaaki, Tanaka, Satoshi, Yamamoto, Akitsugu, Ichimura, Yoshinobu, Ezaki, Junji, Nishida, Keigo, Komazawa-Sakon, Sachiko, Niyonsaba, François, Ishii, Tetsuro, Yanagawa, Toru, Kominami, Eiki, Ogawa, Hideoki, Okumura, Ko, Nakano, Hiroyasu·2011·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2010.12.1078
Open this paper in CoChat — free account

Abstract

Background Autophagy plays a crucial role in controlling various biological responses including starvation, homeostatic turnover of long-lived proteins, and invasion of bacteria. However, a role for autophagy in development and/or function of mast cells is unknown. Objective To investigate a role for autophagy in mast cells, we generated bone marrow-derived mast cells (BMMCs) from mice lacking autophagy related gene (Atg) 7, an essential enzyme for autophagy induction. Methods Bone marrow-derived mast cells were generated from bone marrow cells of control and IFN-inducible Atg7-deficient mice, and morphologic and functional analyses were performed. Results We found that conversion of type I to type II light chain (LC3)-II, a hallmark of autophagy, was constitutively induced in mast cells under full nutrient conditions, and LC3-II localized in secretory granules of mast cells. Although deletion of Atg7 did not impair the development of BMMCs, Atg7(-/-) BMMCs showed severe impairment of degranulation, but not cytokine production on FcεRI cross-linking. Intriguingly, LC3-II but not LC3-I was co-localized with CD63, a secretory lysosomal marker, and was released extracellularly along with degranulation in Atg7(+/+) but not Atg7(-/-) BMMCs. Moreover, passive cutaneous anaphylaxis reactions were severely impaired in mast cell-deficient WBB6F1-W/W(V) mice reconstituted with Atg7(-/-) BMMCs compared with Atg7(+/+) BMMCs. Conclusion These results suggest that autophagy is not essentia…

Overview

Integrity signals

Registry

Crossref · 10.1016/j.jaci.2010.12.1078

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 6 references

Research works printed but not linked: 32

  1. Cadwell, 2009, Role of autophagy and autophagy genes in inflammatory bowel disease, Curr Top Microbiol Immunol, 335, 141
  2. Stappenbeck, 2010, The role of autophagy in Paneth cell differentiation and secretion, Mucosal Immunol, 3, 8, 10.1038/mi.2009.121 · DOI
  3. Jung, 2008, Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia, Cell Metab, 8, 318, 10.1016/j.cmet.2008.08.013 · DOI · Paper page
  4. Ebato, 2008, Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet, Cell Metab, 8, 325, 10.1016/j.cmet.2008.08.009 · DOI · Paper page
  5. Galli, 2005, Mast cells in the development of adaptive immune responses, Nat Immunol, 6, 135, 10.1038/ni1158 · DOI
  6. Galli, 2005, Mast cells as “tunable” effector and immunoregulatory cells: recent advances, Annu Rev Immunol, 23, 749, 10.1146/annurev.immunol.21.120601.141025 · DOI
  7. Supajatura, 2002, Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity, J Clin Invest, 109, 1351, 10.1172/JCI0214704 · DOI
  8. Supajatura, 2001, Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4, J Immunol, 167, 2250, 10.4049/jimmunol.167.4.2250 · DOI
  9. Malaviya, 2001, Mast cell modulation of immune responses to bacteria, Immunol Rev, 179, 16, 10.1034/j.1600-065X.2001.790102.x · DOI
  10. Menager, 2007, Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4, Nat Immunol, 8, 257, 10.1038/ni1431 · DOI
  11. Logan, 2003, Understanding exocytosis in immune and inflammatory cells: the molecular basis of mediator secretion, J Allergy Clin Immunol, 111, 923, 10.1016/S0091-6749(03)80114-8 · DOI
  12. Komatsu, 2007, Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice, Cell, 131, 1149, 10.1016/j.cell.2007.10.035 · DOI · Paper page
  13. Mizushima, 2004, In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker, Mol Biol Cell, 15, 1101, 10.1091/mbc.e03-09-0704 · DOI · Paper page
  14. Niyonsaba, 2010, Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells, J Immunol, 184, 3526, 10.4049/jimmunol.0900712 · DOI
  15. Kamijo, 2009, Cupressaceae pollen grains modulate dendritic cell response and exhibit IgE-inducing adjuvant activity in vivo, J Immunol, 183, 6087, 10.4049/jimmunol.0901039 · DOI
  16. Miyoshi, 2004, Gene delivery to hematopoietic stem cells using lentiviral vectors, Methods Mol Biol, 246, 429
  17. Nishida, 2005, Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane, J Cell Biol, 170, 115, 10.1083/jcb.200501111 · DOI
  18. Metzelaar, 1991, CD63 antigen: a novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells, J Biol Chem, 266, 3239, 10.1016/S0021-9258(18)49980-2 · DOI
  19. Fader, 2009, Autophagy and multivesicular bodies: two closely related partners, Cell Death Differ, 16, 70, 10.1038/cdd.2008.168 · DOI
  20. Komatsu, 2006, Loss of autophagy in the central nervous system causes neurodegeneration in mice, Nature, 441, 880, 10.1038/nature04723 · DOI · Paper page
  21. Moscat, 2009, p62 at the crossroads of autophagy, apoptosis, and cancer, Cell, 137, 1001, 10.1016/j.cell.2009.05.023 · DOI · Paper page
  22. Manjithaya, 2010, Unconventional secretion of Pichia pastoris Acb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation, J Cell Biol, 188, 537, 10.1083/jcb.200911149 · DOI
  23. Duran, 2010, Unconventional secretion of Acb1 is mediated by autophagosomes, J Cell Biol, 188, 527, 10.1083/jcb.200911154 · DOI · Paper page
  24. Nickel, 2009, Mechanisms of regulated unconventional protein secretion, Nat Rev Mol Cell Biol, 10, 148, 10.1038/nrm2617 · DOI
  25. Tiwari, 2008, VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways, Blood, 111, 3665, 10.1182/blood-2007-07-103309 · DOI
  26. Puri, 2008, Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms, Proc Natl Acad Sci U S A, 105, 2580, 10.1073/pnas.0707854105 · DOI
  27. Dvorak, 2005, Ultrastructural studies of human basophils and mast cells, J Histochem Cytochem, 53, 1043, 10.1369/jhc.5R6647.2005 · DOI
  28. Andrews, 2000, Regulated secretion of conventional lysosomes, Trends Cell Biol, 10, 316, 10.1016/S0962-8924(00)01794-3 · DOI
  29. Komatsu, 2007, Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice, Cell, 131, 1149, 10.1016/j.cell.2007.10.035 · DOI · Paper page
  30. Komatsu, 2005, Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice, J Cell Biol, 169, 425, 10.1083/jcb.200412022 · DOI · Paper page
  31. Supajatura, 2002, Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity, J Clin Invest, 109, 1351, 10.1172/JCI0214704 · DOI
  32. Chen, 2007, Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability, Eur J Immunol, 37, 434, 10.1002/eji.200636379 · DOI

Cited by

Sorted by citations

Metadata

Authors
Ushio, H., Ueno, T., Kojima, Y., Komatsu, M., Tanaka, S., Yamamoto, A., Ichimura, Y., Ezaki, J., Nishida, K., Komazawa-Sakon, S., Niyonsaba, F., Ishii, T., Yanagawa, T., Kominami, E., Ogawa, H., Okumura, K., & Nakano, H.
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2011-05
Volume
127
Issue
5
Pages
1267-1276.e6
ISSN
0091-6749
DOI
10.1016/j.jaci.2010.12.1078
Cited by
124
References
6
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review