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Cited by 600

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

Open access
Moore, Wendy C., Hastie, Annette T., Li, Xingnan, Li, Huashi, Busse, William W., Jarjour, Nizar N., Wenzel, Sally E., Peters, Stephen P., Meyers, Deborah A., Bleecker, Eugene R.·2014·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2013.10.011
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Abstract

Background Clinical cluster analysis from the Severe Asthma Research Program (SARP) identified five asthma subphenotypes that represent the severity spectrum of early onset allergic asthma, late onset severe asthma and severe asthma with COPD characteristics. Analysis of induced sputum from a subset of SARP subjects showed four sputum inflammatory cellular patterns. Subjects with concurrent increases in eosinophils (≥2%) and neutrophils (≥40%) had characteristics of very severe asthma. Objective To better understand interactions between inflammation and clinical subphenotypes we integrated inflammatory cellular measures and clinical variables in a new cluster analysis. Methods Participants in SARP at three clinical sites who underwent sputum induction were included in this analysis (n=423). Fifteen variables including clinical characteristics and blood and sputum inflammatory cell assessments were selected by factor analysis for unsupervised cluster analysis. Results Four phenotypic clusters were identified. Cluster A (n=132) and B (n=127) subjects had mild-moderate early onset allergic asthma with paucigranulocytic or eosinophilic sputum inflammatory cell patterns. In contrast, these inflammatory patterns were present in only 7% of Cluster C (n=117) and D (n=47) subjects who had moderate-severe asthma with frequent health care utilization despite treatment with high doses of inhaled or oral corticosteroids, and in Cluster D, reduced lung function. The majority these subjects (>83%) had sputum neutrophilia either alone or with concurrent sputum eosinophilia. Baseline lung function and sputum neutrophils were the most important variables determining cluster assignment. Conclusion This multivariate approach identified four asthma subphenotypes representing the severity spectrum from mild-moderate allergic asthma with minimal or eosinophilic predominant sputum inflammation to moderate-severe asthma with neutrophilic predominant or mixed granulocytic inflammation.

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Metadata

Authors
Moore, W. C., Hastie, A. T., Li, X., Li, H., Busse, W. W., Jarjour, N. N., Wenzel, S. E., Peters, S. P., Meyers, D. A., & Bleecker, E. R.
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2014-06
Volume
133
Issue
6
Pages
1557-1563.e5
ISSN
0091-6749 (ISSN-L)
DOI
10.1016/j.jaci.2013.10.011
OpenAlex
W1964669406
Cited by
600
References
30
FWCI
19.18
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. https://app.cochat.ai/papers/10.1016/j.jaci.2013.10.011
The paper
Moore, W. C., Hastie, A. T., Li, X., Li, H., Busse, W. W., Jarjour, N. N., Wenzel, S. E., Peters, S. P., Meyers, D. A., & Bleecker, E. R. (2014). Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2013.10.011

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.