The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
Open accessAbstract
U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach. This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements. Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12 months; p<0.001), with worse quality of life, and higher levels of anxiety and depression. They also had a higher incidence of nasal polyps and gastro-oesophageal reflux with lower lung function. Sputum eosinophil count was higher in severe asthma compared to mild/moderate asthma (median count 2.99%versus 1.05%; p=0.004) despite treatment with higher doses of inhaled and/or oral corticosteroids. Consistent with other severe asthma cohorts, U-BIOPRED is characterised by poor symptom control, increased comorbidity and airway inflammation, despite high levels of treatment. It is well suited to identify asthma phenotypes using the array of “omic” datasets that are at the core of this systems medicine approach.
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The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139
A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale
Johns, M. W. (1991) · Sleep · doi:10.1093/sleep/14.6.540 · Cited by 17,364
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Chung, K. F., Wenzel, S. E., Brozek, J. L., Bush, A., Castro, M., Sterk, P. J., Adcock, I. M., Bateman, E. D., Bel, E. H., Bleecker, E. R., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00202013 · Cited by 3,926
Self-citationDevelopment and validation of a questionnaire to measure asthma control
Juniper, E. F., O′byrne, P. M., Guyatt, G. H., Ferrie, P. J., & King, D. R. (1999) · European Respiratory Journal · doi:10.1034/j.1399-3003.1999.14d29.x · Cited by 2,473
Asthma phenotypes: the evolution from clinical to molecular approaches
Wenzel, S. E. (2012) · Nature Medicine · doi:10.1038/nm.2678 · Cited by 2,412
Pavord, I. D., Korn, S., Howarth, P., Bleecker, E. R., Buhl, R., Keene, O. N., Ortega, H., & Chanez, P. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60988-x · Cited by 2,221
Self-citationCluster analysis and clinical asthma phenotypes
Haldar, P., Pavord, I. D., Shaw, D. E., Berry, M. A., Thomas, M., Brightling, C. E., Wardlaw, A. J., & Green, R. H. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200711-1754oc · Cited by 1,987
Self-citationReddel, H. K., Taylor, D. R., Bateman, E. D., Boulet, L.-P., Boushey, H. A., Busse, W. W., Casale, T. B., Chanez, P., Enright, P. L., Gibson, P. G., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200801-060st · Cited by 1,918
Self-citationA double‐blind, placebo‐controlled trial
Pinals, R. S., Kaplan, S. B., Lawson, J. G., & Hepburn, B. (1986) · Arthritis & Rheumatism · doi:10.1002/art.1780291202 · Cited by 1,355
Dupilumab in Persistent Asthma with Elevated Eosinophil Levels
Wenzel, S., Ford, L., Pearlman, D., Spector, S., Sher, L., Skobieranda, F., Wang, L., Kirkesseli, S., Rocklin, R., Bock, B., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1304048 · Cited by 1,320
Cited by
Making sense of big data in health research: towards an EU action plan
Auffray, C., Balling, R., Barroso, I., Bencze, L., Benson, M., Bergeron, J., Bernal-Delgado, E., Blomberg, N., Bock, C., Conesa, A., et al. (2016) · Genome Medicine · doi:10.1186/s13073-016-0323-y · Cited by 286
Self-citationCo‐morbidities in severe asthma: Clinical impact and management
Porsbjerg, C., & Menzies‐Gow, A. (2017) · Respirology · doi:10.1111/resp.13026 · Cited by 233
Del Giacco, S. R., Cappai, A., Gambula, L., Cabras, S., Perra, S., Manconi, P. E., Carpiniello, B., & Pinna, F. (2016) · Respiratory Medicine · doi:10.1016/j.rmed.2016.09.014 · Cited by 85
Anxiety Contributes to Poorer Asthma Outcomes in Inner-City Black Adolescents
Shams, M. R., Bruce, A. C., & Fitzpatrick, A. M. (2018) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2017.06.034 · Cited by 53
High prevalence of severe asthma in a large random population study
Mincheva, R., Ekerljung, L., Bossios, A., Lundbäck, B., & Lötvall, J. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.07.047 · Cited by 37
Metadata
- Authors
- Shaw, D. E., Sousa, A. R., Fowler, S. J., Fleming, L. J., Roberts, G., Corfield, J., Pandis, I., Bansal, A. T., Bel, E. H., Auffray, C., Compton, C. H., Bisgaard, H., Bucchioni, E., Caruso, M., Chanez, P., Dahlén, B., Dahlen, S.-E., Dyson, K., Frey, U., Geiser, T., Gerhardsson de Verdier, M., Gibeon, D., Guo, Y.-K., Hashimoto, S., Hedlin, G., Jeyasingham, E., Hekking, P.-P. W., Higenbottam, T., Horváth, I., Knox, A. J., Krug, N., Erpenbeck, V. J., Larsson, L. X., Lazarinis, N., Matthews, J. G., Middelveld, R., Montuschi, P., Musial, J., Myles, D., Pahus, L., Sandström, T., Seibold, W., Singer, F., Strandberg, K., Vestbo, J., Vissing, N., von Garnier, C., Adcock, I. M., Wagers, S., Rowe, A., Howarth, P., Wagener, A. H., Djukanovic, R., Sterk, P. J., & Chung, K. F.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2015-09-10
- Volume
- 46
- Issue
- 5
- Pages
- 1308-1321
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2119706375
- Cited by
- 555
- References
- 36
- FWCI
- 33.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shaw, D. E., Sousa, A. R., Fowler, S. J., Fleming, L. J., Roberts, G., Corfield, J., Pandis, I., Bansal, A. T., Bel, E. H., Auffray, C., Compton, C. H., Bisgaard, H., Bucchioni, E., Caruso, M., Chanez, P., Dahlén, B., Dahlen, S.-E., Dyson, K., Frey, U., . . . Chung, K. F. (2015). Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. European Respiratory Journal. https://doi.org/10.1183/13993003.00779-2015
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