Histamine receptor 2 is a key influence in immune responses to intestinal histamine-secreting microbes
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L. reuteri modulates host gut immune function and intestinal inflammation via the histamine H2 receptor.
“Perhaps most interestingly, L. reuteri was shown to modulate host gut immune function (Ferstl et al., 2014), as well as intestinal inflammation via the histamine H2 receptor (Gao et al., 2015).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Ferstl et al., 2014
Ferstl et al. is cited for the claim that L. reuteri modulates host gut immune function; the separate H2-receptor claim is attributed to Gao et al. Figure 1 reports that L. reuteri supernatant increased LPS-induced NF-κB activation in vitro, supporting an effect on an immune-response measure, but not demonstrating modulation of gut immune function in a host. The paper’s gut immune experiments used L. saerimneri 30a instead. (LLM, conf=0.84)
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Research works printed but not linked: 9
- Ruth Ferstl, PhD a Remo Frei, PhD a,b Elisa Schiavi, PhD a Patrycja Konieczna, PhD a Weronika Barcik, MSc a Mario Ziegler, Dipl-Ing a Roger P. Lauener, MD b,c Christophe Chassard, PhD d Christophe Lacroix, PhD d Cezmi A. Akdis, MD a,b Liam O'Mahony, PhD a REFERENCES 1. Pfefferle PI, Prescott SL, Kopp M. Microbial influence on tolerance and opportu- nities for intervention with prebiotics/probiotics and bacterial lysates. J Allergy Clin Immunol 2013;131:1453-63.
- Frei R, Lauener RP, Crameri R, O'Mahony L. Microbiota and dietary interactions: an update to the hygiene hypothesis? Allergy 2012;67:451-61.
- Konieczna P, Akdis CA, Quigley EM, Shanahan F, O'Mahony L. Portrait of an immunoregulatory Bifidobacterium. Gut Microbes 2012;3:261-6.
- O'Mahony L, Akdis M, Akdis CA. Regulation of the immune response and inflam- mation by histamine and histamine receptors. J Allergy Clin Immunol 2011;128: 1153-62.
- Frei R, Ferstl R, Konieczna P, Ziegler M, Simon T, Rugeles TM, et al. Histamine receptor 2 modifies dendritic cell responses to microbial ligands. J Allergy Clin Immunol 2013;132:194-204.
- Romano A, Trip H, Campbell-Sills H, Bouchez O, Sherman D, Lolkema JS, et al. Genome sequence of Lactobacillus saerimneri 30a (formerly Lactobacillus sp. strain 30a), a reference lactic acid bacterium strain producing biogenic amines. Genome Announc 2013;1:e00097-12.
- Smolinska S, Jutel M, Crameri R, O'Mahony L. Histamine and gut mucosal immune regulation. Allergy 2014;69:273-81.
- Thomas CM, Hong T, van Pijkeren JP, Hemarajata P, Trinh DV, Hu W, et al. His- tamine derived from probiotic Lactobacillus reuteri suppresses TNF via modula- tion of PKA and ERK signaling. PLoS One 2012;7:e31951.
- Til HP, Falke HE, Prinsen MK, Willems MI. Acute and subacute toxicity of tyra- mine, spermidine, spermine, putrescine and cadaverine in rats. Food Chem Toxicol 1997;35:337-48. Available online June 20, 2014. http://dx.doi.org/10.1016/j.jaci.2014.04.034
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Prebiotics, probiotics, synbiotics, and the immune system: experimental data and clinical evidence
Frei, R., Akdis, M., & O’Mahony, L. (2015) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000151 · Cited by 240 · see citing works
Self-citationGao, C., Ganesh, B. P., Shi, Z., Shah, R. R., Fultz, R., Major, A., Venable, S., Lugo, M., Hoch, K., Chen, X., et al. (2017) · The American Journal of Pathology · doi:10.1016/j.ajpath.2017.06.011 · Cited by 122 · see citing works
Bacterial Secretion of Histamine Within the Gut Influences Immune Responses Within the Lung
Barcik, W., Pugin, B., Brescó, M. S., Westermann, P., Rinaldi, A., Groeger, D., Van Elst, D., Sokolowska, M., Krawczyk, K., Frei, R., et al. (2019) · Allergy · doi:10.1111/all.13709 · Cited by 98 · see citing works
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- Authors
- Ferstl, R., Frei, R., Schiavi, E., Konieczna, P., Barcik, W., Ziegler, M., Lauener, R. P., Chassard, C., Lacroix, C., Akdis, C. A., & O'Mahony, L.
- Affiliations
- University of Zurich (CH)
- Kantonsspital St. Gallen (CH)
- ETH Zurich (CH)
- ORCID
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 134
- Issue
- 3
- Pages
- 744-746.e3
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2112069942
- Cited by
- 70
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 2 · 2019: 3 · 2018: 11 · 2017: 11 · 2016: 8 · 2015: 7
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Seventh Framework Programme (260895)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (261357, 310030_144219, 310030-127356)
- European Commission
- Universität Zürich
- Novartis
- H2020 Marie Skłodowska-Curie Actions
- Christine Kühne – Center for Allergy Research and Education
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- histamine, gut microbiota, immune regulation, mucosal tolerance, Lactobacillus rhamnosus, anti-inflammatory activity, intestinal immune homeostasis
- MeSH terms
- Animals, Cell Line, Histamine, Humans, Immunity, Intestines, Lactobacillus, Mice, Inbred Strains, Receptors, Histamine H2, Famotidine, Cytokines, NF-kappa B, Mice, Knockout, Coculture Techniques, Mice, Immunomodulation, Microbiota
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