Bacterial Secretion of Histamine Within the Gut Influences Immune Responses Within the Lung
Open accessAbstract
Background: Histamine is an important immunomodulator influencing both the innate and adaptive immune system. Certain host cells express the histidine decarboxylase enzyme (HDC), which is responsible for catalysing the decarboxylation of histidine to histamine. We and others have shown that bacterial strains can also express HDC and secrete histamine; however, the influence of bacterial‐derived histamine on the host immune responses distant to the gut is unclear. Methods: The Escherichia coli BL 21 (E coli BL 21) strain was genetically modified to express the Morganella morganii (M morganii)‐derived HDC gene (E coli BL 21_ HTW). E coli BL 21 and E coli BL 21_ HTW were gavaged to ovalbumin (OVA) sensitized and challenged mice to investigate the effect of bacterial‐derived histamine on lung inflammatory responses. Results: Oral administration of E coli BL 21_ HTW, which is able to secrete histamine, to wild‐type mice reduced lung eosinophilia and suppressed ex vivo OVA‐stimulated cytokine secretion from lung cells in the OVA respiratory inflammation mouse model. In histamine receptor 2 (H2R)‐deficient mice, administration of histamine‐secreting bacteria also reduced inflammatory cell numbers in bronchoalveolar lavage (BAL). However, the suppressive effect of bacterial‐derived histamine on BAL inflammation was lost in HDC‐deficient mice. This loss of activity was associated with increased expression of histamine degrading enzymes and reduced histamine receptor expression. Conclusion: Histamine secretion from bacteria within the gut can have immunological consequences at distant mucosal sites, such as within the lung. These effects are influenced by host histamine receptor expression and the expression of histamine degrading enzymes.
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Mice treated with histamine-secreting E. coli BL21_HTW showed decreased lung eosinophilia and depressed OVA-sensitized cytokine secretion from lung cells in an airway inflammation model.
“mice treated with E. coli BL21_HTW, bacteria that secrete histamine after genetic modification, showed decreased lung eosinophilia and depressed ovalbumin (OVA)-sensitized cytokine secretion from lung cells in an airway inflammation model (45).”
From The Role of Gut Microbiota in Lung Cancer: From Carcinogenesis to Immunotherapy (2021) · cites this paper as [45]
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Research works printed but not linked: 1
- Sokolowska M, Frei R, Lunjani N, Akdis CA, O'Mahony L. Micro- biome and asthma. Asthma Res Pract. 2018;4:1.
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RETRACTED ARTICLE: Role of the gut microbiome in chronic diseases: a narrative review
Vijay, A., & Valdes, A. M. (2022) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00991-6 · Cited by 361 · see citing works
Retracted
- Authors
- Barcik, W., Pugin, B., Brescó, M. S., Westermann, P., Rinaldi, A., Groeger, D., Van Elst, D., Sokolowska, M., Krawczyk, K., Frei, R., Ferstl, R., Wawrzyniak, M., Altunbulakli, C., Akdis, C. A., & O'Mahony, L.
- Affiliations
- University of Zurich (CH)
- Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland
- Alimentary Health Pharma Davos (AHPD) Davos Switzerland
- ORCID
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2019-02-07
- Volume
- 74
- Issue
- 5
- Pages
- 899-909
- ISSN
- 0105-4538 (ISSN-L)
- 1398-9995
- OpenAlex
- W2907024057
- Cited by
- 98
- References
- 44
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 17 · 2023: 9 · 2022: 14 · 2021: 21 · 2020: 15 · 2019: 2 · 2018: 1
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Allergy (publishedVersion)
- PubMed (publishedVersion)
- Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (CRSII3_154488, 310030_144219, 310030‐127356)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Keywords
- histidine decarboxylase, gut-lung axis, lung eosinophilia, ovalbumin-induced airway inflammation, Morganella morganii, Escherichia coli, oral gavage, bronchoalveolar lavage inflammation, cytokine inhibition
- MeSH terms
- Gastrointestinal Microbiome, Animals, Bacteria, Disease Models, Animal, Escherichia coli, Histamine, Histidine Decarboxylase, Immunity, Inflammation, Lung, Receptors, Histamine H2, Bacterial Physiological Phenomena, Mice
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