The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Histologic eosinophilic gastritis is a systemic disorder associated with blood and extragastric eosinophilia, TH2 immunity, and a unique gastric transcriptome
Open accessAbstract
Background The definition of eosinophilic gastritis (EG) is currently limited to histological EG based on the tissue eosinophil count. Objective We aimed to provide additional fundamental information about the molecular, histopathological, and clinical characteristics of EG. Methods Genome-wide transcript profiles and histological features of gastric biopsies as well as blood eosinophil numbers were analyzed in EG and control patients (n = 15 each). Results The peak gastric antrum eosinophil count was 282.7 ± 163.9 eosinophils/400X high-power field (HPF) in EG and 11.0 ± 8.5 eosinophils/HPF in control patients (P = 6.1 × 10−7). EG patients (87%) had co-existing eosinophilic inflammation in multiple gastrointestinal segments; the esophagus represented the most common secondary site. Elevated peripheral blood eosinophil numbers (EG 1.09 ± 0.88 × 103 [K]/μl vs. control 0.09 ± 0.08 K/μl, P = .0027) positively correlated with peak gastric eosinophil counts (Pearson r2 = .8102, P < .0001). MIB-1+ (proliferating), CD117+ (mast cells), and FOXP3+ cells (regulatory and/or activated T cells) were increased in EG. Transcript profiling revealed changes in 8% of the genome in EG gastric tissue. Only 7% of this EG transcriptome overlapped with the eosinophilic esophagitis (EoE) transcriptome. Significantly increased IL4, IL5, IL13, IL17, CCL26 and mast cell-specific transcripts and decreased IL33 were observed. Conclusion EG is a systemic disorder involving profound blood and gastrointestinal tract eosinophilia, Th2 immunity, and a conserved gastric transcriptome markedly distinct from the EoE transcriptome. The data herein define germane cellular and molecular pathways of EG and provide a basis for improving diagnosis and treatment.
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Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists
Eden, E., Navon, R., Steinfeld, I., Lipson, D., & Yakhini, Z. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-48 · Cited by 3,356
Michalek, R. D., Gerriets, V. A., Jacobs, S. R., Macintyre, A. N., MacIver, N. J., Mason, E. F., Sullivan, S. A., Nichols, A. G., & Rathmell, J. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003613 · Cited by 2,091
Transient expression of FOXP3 in human activated nonregulatory CD4 + T cells
Wang, J., Ioan‐Facsinay, A., van der Voort, E. I. H., Huizinga, T. W. J., & Toes, R. E. M. (2007) · European Journal of Immunology · doi:10.1002/eji.200636435 · Cited by 1,011
High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders
Abonia, J. P., Wen, T., Stucke, E. M., Grotjan, T., Griffith, M. S., Kemme, K. A., Collins, M. H., Putnam, P. E., Franciosi, J. P., von Tiehl, K. F., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.02.030 · Cited by 195
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Metadata
- Authors
- Caldwell, J. M., Collins, M. H., Stucke, E. M., Putnam, P. E., Franciosi, J. P., Kushner, J. P., Abonia, J. P., & Rothenberg, M. E.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 134
- Issue
- 5
- Pages
- 1114-1124
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2091925781
- Cited by
- 185
- References
- 5
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Caldwell, J. M., Collins, M. H., Stucke, E. M., Putnam, P. E., Franciosi, J. P., Kushner, J. P., Abonia, J. P., & Rothenberg, M. E. (2014). Histologic eosinophilic gastritis is a systemic disorder associated with blood and extragastric eosinophilia, TH2 immunity, and a unique gastric transcriptome. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2014.07.026
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