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Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

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Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

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Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity

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Tracking cancer drugs in living cells by thermal profiling of the proteome

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Microglia development follows a stepwise program to regulate brain homeostasis

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Microglial brain region-dependent diversity and selective regional sensitivities to aging

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Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

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Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

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Lysosome-targeting chimaeras for degradation of extracellular proteins

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The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

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Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

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Normalizing the environment recapitulates adult human immune traits in laboratory mice

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Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

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A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain

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The complex transcriptional landscape of the anucleate human platelet

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LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation

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A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains

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Domestication and Divergence of Saccharomyces cerevisiae Beer Yeasts

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Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

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Physiological blood–brain transport is impaired with age by a shift in transcytosis

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A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

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Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

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Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears

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A cellular and spatial map of the choroid plexus across brain ventricles and ages

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Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity

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Million-year-old DNA sheds light on the genomic history of mammoths

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Trade-off between transcriptome plasticity and genome evolution in cephalopods

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A Synergistic Core for Human Brain Evolution and Cognition

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Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding

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The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death

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Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology

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Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice

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pH-gated succinate secretion regulates muscle remodeling in response to exercise

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Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

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Normative brain size variation and brain shape diversity in humans

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Functional Genetic Variants Revealed by Massively Parallel Precise Genome Editing

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IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease

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Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach

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Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells

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A Differential Wiring Analysis of Expression Data Correctly Identifies the Gene Containing the Causal Mutation

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scSLAM-seq reveals core features of transcription dynamics in single cells

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i-cisTarget 2015 update: generalized cis-regulatory enrichment analysis in human, mouse and fly

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A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain

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Cell-type-specific metabolic labeling of nascent proteomes in vivo

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Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain

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Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease

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Metabolic Turnover of Synaptic Proteins: Kinetics, Interdependencies and Implications for Synaptic Maintenance

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Sex-chromosome dosage effects on gene expression in humans

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Identifying drug targets in tissues and whole blood with thermal-shift profiling

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