Statins and their influence on brain cholesterol
Abstract
Background Growing evidence suggests that different statins are able to lower brain cholesterol synthesis. It is not clear yet whether lipophilic statins influence brain cholesterol in different way than hydrophilic ones. SOURCES OF MATERIAL: The MEDLINE database. Findings According to the data reported thus far, statins may influence brain cholesterol metabolism directly (because they are able to penetrate BBB no matter whether they are hydrophilic or lipophilic) and also indirectly (by lowering plasma cholesterol). Although the definite mechanism is not known yet, it becomes obvious that statins do not only influence peripheral but also central cholesterol pool. Conclusion Better understanding of the effects of statins on brain metabolism becomes more important because many studies bring evidence of a possible link between cholesterol and neurodegeneration.
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Statin drugs likely alter brain cholesterol through indirect effects of altered systemic lipid metabolism.
“The precise mechanisms by which statin drugs alter brain cholesterol are unknown, but likely include indirect effects of altered systemic lipid metabolism48,49.”
From A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome (2013) · cites this paper as [48]
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A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome
Buchovecky, C. M., Turley, S. D., Brown, H. M., Kyle, S. M., McDonald, J. G., Liu, B., Pieper, A. A., Huang, W., Katz, D. M., Russell, D. W., et al. (2013) · Nature Genetics · doi:10.1038/ng.2714 · Cited by 234 · see citing works
Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine
Eid, A., Mhatre, I., & Richardson, J. R. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.03.005 · Cited by 164 · see citing works
- Authors
- Cibičková, L.
- Venue
- Journal of Clinical Lipidology
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 5
- Issue
- 5
- Pages
- 373-379
- ISSN
- 1876-4789 (ISSN-L)
- 1933-2874
- OpenAlex
- W1999656223
- Cited by
- 58
- References
- 3
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 3 · 2019: 2 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 6
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of clinical lipidology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- statins, brain cholesterol, cholesterol biosynthesis, blood-brain barrier penetration, lipophilic statins, hydrophilic statins, serum cholesterol, neurodegeneration
- MeSH terms
- Alzheimer Disease, Blood-Brain Barrier, Brain, Cholesterol, Humans, Databases, Factual, Hydroxymethylglutaryl-CoA Reductase Inhibitors
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