Atorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated tau in aged APP mice
Abstract
In addition to simply reducing the serum level of cholesterol, 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have various pleiotrophic effects such as reducing oxidative stress, neuroinflammation, and neurotoxicity. However, such a pleiotrophic effect has not been fully studied in a new statin (pitavastatin). We examined and compared the effects of two strong statins (atorvastatin, 30 mg/kg/day, p.o.; pitavastatin, 3mg/kg/day, p.o.) on the serum level of lipids, cognitive dysfunction, senile plaque (SP) and phosphorylated tau-positive dystrophic neuritis (pτDN) in amyloid precursor protein (APP) transgenic (Tg) mice from 5 months (M) of age to 20 M. These two statins improved behavioral memory and reduced the numbers of SP and pτDN at 15 and 20 M without affecting serum lipid levels, but preserved mice brain weight in pitavastatin group at 20 M. These protective effects of statins took 10 M from the beginning of treatment to show an improvement in the present model mice, and sensitivity to the statin treatment was linked to behavioral memory, SP and pτDN in this order. These findings suggest that early treatment with both atorvastatin and pitavastatin prevented subsequent worsening of cognitive function and the amyloidogenic process, probably due to pleiotrophic effects, suggesting a therapeutic potential for Alzheimer's disease (AD).
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
APP mouse models of AD demonstrate cognitive decline with pathology comprising Aβ plaques closely associated with areas of high oxidative stress and dystrophic neurites.
“APP mouse models of AD demonstrate cognitive decline with pathology, comprising Aβ plaques closely associated with areas of high oxidative stress and dystrophic neurites [14,15].”
From Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice (2019) · cites this paper as [14]
Cites
Alzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420 · see citing works
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., & Glabe, C. G. (2003) · Science · doi:10.1126/science.1079469 · Cited by 4,064 · see citing works
Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506 · see citing works
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668 · see citing works
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
Roberson, E. D., Scearce-Levie, K., Palop, J. J., Yan, F., Cheng, I. H., Wu, T., Gerstein, H., Yu, G.-Q., & Mucke, L. (2007) · Science · doi:10.1126/science.1141736 · Cited by 1,892 · see citing works
Statins and the risk of dementia
Jick, H., Zornberg, G. L., Jick, S. S., Seshadri, S. S., & Drachman, D. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03155-x · Cited by 1,763 · see citing works
Wolozin, B., Kellman, W., Ruosseau, P., Celesia, G., & Siegel, G. (2000) · Archives of Neurology · doi:10.1001/archneur.57.10.1439 · Cited by 1,499 · see citing works
Fassbender, K. C., Simons, M., Bergmann, C., Stroick, M., Lütjohann, D., Keller, P., Runz, H., Kühl, S., Bertsch, T., von Bergmann, K., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081620098 · Cited by 1,078 · see citing works
Kawarabayashi, T., Younkin, L. H., Saido, T. C., Shoji, M., Ashe, K. H., & Younkin, S. G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00372.2001 · Cited by 1,053 · cited 1× · see citing works
“…month; MC, methylcellulose; NFTs, neurofibrillary tangles; pτDN, ho, total cholesterol; Tg, transgenic; TG, triglyceride . thebrainhad substantialAβamyloiddeposits (Hsiao et al., 1996; Kawarabayashi et al., 2001) with memory disturbance and subsequent typical pathological characteristics of AD.”
BackgroundHypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model
Refolo, L. M., Pappolla, M. A., Malester, B., LaFrancois, J. J., Bryant‐Thomas, T., Wang, R., Tint, G. S., Sambamurti, K., & Duff, K. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0304 · Cited by 1,003 · see citing works
Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?
Klein, W. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01749-5 · Cited by 989 · see citing works
Refolo, L. M., Pappolla, M. A., LaFrancois, J. J., Malester, B., Schmidt, S. D., Thomas-Bryant, T., Tint, G. S., Wang, R., Mercken, M. H., Petanceska, S. S., et al. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0422 · Cited by 521 · see citing works
Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers
De Felice, F. G., Wu, D., Lambert, M. P., Fernandez, S. J., Velasco, P. T., Lacor, P. N., Bigio, E. H., Jerecic, J., Acton, P. J., Shughrue, P. J., et al. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.02.029 · Cited by 432 · see citing works
Tomiyama, T., Matsuyama, S., Iso, H., Umeda, T., Takuma, H., Ohnishi, K., Ishibashi, K., Teraoka, R., Sakama, N., Yamashita, T., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5825-09.2010 · Cited by 396 · see citing works
Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease
Li, G., Larson, E. B., Sonnen, J. A., Shofer, J. B., Petrie, E. C., Schantz, A. M., Peskind, E. R., Raskind, M. A., Breitner, J. C. S., & Montine, T. J. (2007) · Neurology · doi:10.1212/01.wnl.0000277657.95487.1c · Cited by 237 · see citing works
Cordle, A. C., & Landreth, G. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2544-04.2005 · Cited by 177 · see citing works
Statin therapy for Alzheimer’s disease
Petanceska, S. S., DeRosa, S., Olm, V., Diaz, N. S., Sharma, A., Bryant‐Thomas, T., Duff, K., Pappolla, M. A., & Refolo, L. M. (2002) · Journal of Molecular Neuroscience · doi:10.1007/s12031-002-0026-2 · Cited by 153 · see citing works
Simvastatin enhances learning and memory independent of amyloid load in mice
Li, L., Cao, D., Kim, H., Lester, R. A. J., & Fukuchi, K. (2006) · Annals of Neurology · doi:10.1002/ana.21053 · Cited by 150 · see citing works
Sparks, D. L., Connor, D. J., Sabbagh, M. N., Petersen, R. B., Lopez, J., & Browne, P. J. (2006) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00690.x · Cited by 130 · see citing works
Tong, X.-K., Nicolakakis, N., Fernandes, P., Ongali, B., Brouillette, J., Quirion, R., & Hamel, E. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.003 · Cited by 122 · see citing works
Statins: Multiple Mechanisms of Action in the Ischemic Brain
Cimino, M., Gelosa, P., Gianella, A., Nobili, E., Tremoli, E., & Sironi, L. (2007) · The Neuroscientist · doi:10.1177/1073858406297121 · Cited by 101 · see citing works
Nomura, S., Inami, N., Shouzu, A., Omoto, S., Kimura, Y., Takahashi, N., Tanaka, A., Urase, F., Maeda, Y., Ohtani, H., et al. (2009) · Platelets · doi:10.1080/09537100802409921 · Cited by 98 · see citing works
Carlsson, C. M., Gleason, C. E., Hess, T., Moreland, K. A., Blazel, H. M., Koscik, R. L., Schreiber, N. T. N., Johnson, S. C., Atwood, C., Puglielli, L., et al. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13209 · Cited by 92 · see citing works
Statins reduce the neurofibrillary tangle burden in a mouse model of tauopathy
Boimel, M., Grigoriadis, N., Lourbopoulos, A., Touloumi, O., Rosenmann, D., Abramsky, O., & Rosenmann, H. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31819ac3cb · Cited by 86 · see citing works
NK-104: a novel synthetic HMG-CoA reductase inhibitor
Kajinami, K., Mabuchi, H., & Saito, Y. (2000) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.9.11.2653 · Cited by 85 · see citing works
Chauhan, N. B., Siegel, G. J., & Feinstein, D. L. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000042217.90204.8d · Cited by 77 · see citing works
Morikawa, S., Umetani, M., Nakagawa, S., Yamazaki, H., Suganami, H., Inoue, K., Kitahara, M., Hamakubo, T., Kodama, T., & Saitō, Y. (2000) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat1994.7.138 · Cited by 76 · see citing works
Okada, M., Tamura, A., Urae, A., Nakagomi, T., Kirino, T., Mine, K., & Fujiwara, M. (1995) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1995.62 · Cited by 68 · see citing works
Role of GSK‐3β activation and α7 nAChRs in Aβ1–42‐induced tau phosphorylation in PC12 cells
Hu, M., Waring, J. F., Gopalakrishnan, M., & Li, J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05483.x · Cited by 67 · see citing works
Hypolipidemic effect of NK-104, a potent HMG-CoA reductase inhibitor, in guinea pigs
Suzuki, H., Aoki, T., Tamaki, T., Sato, F., Kitahara, M., & Saitō, Y. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00146-x · Cited by 65 · see citing works
Nachtigal, P., Jamborova, G., Pospisilova, N., Pospěchová, K., Solichová, D., Zdansky, P., & Semecký, V. (2006) · PubMed · Cited by 25 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Amyloid-β-independent regulators of tau pathology in Alzheimer disease
van der Kant, R., Goldstein, L. S. B., & Ossenkoppele, R. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0240-3 · Cited by 580 · see citing works
Pharmacological Actions of Statins: A Critical Appraisal in the Management of Cancer
Gazzerro, P., Proto, M., Gangemi, G., Malfitano, A. M., Ciaglia, E., Pisanti, S., Santoro, A., Laezza, C., & Bifulco, M. (2011) · Pharmacological Reviews · doi:10.1124/pr.111.004994 · Cited by 458 · see citing works
Cholesterol: its regulation and role in central nervous system disorders
Orth, M., & Bellosta, S. (2012) · Cholesterol · doi:10.1155/2012/292598 · Cited by 339 · see citing works
Di Domenico, F., Tramutola, A., & Butterfield, D. A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.490 · Cited by 253 · see citing works
Dai, X., Fan, Y., & Zhao, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02168-0 · Cited by 258 · see citing works
Foster, P. P., Rosenblatt, K. P., & Kuljiš, R. O. (2011) · Frontiers in Neurology · doi:10.3389/fneur.2011.00028 · Cited by 204 · see citing works
Molecular Mechanisms Underlying the Effects of Statins in the Central Nervous System
McFarland, A. J., Anoopkumar‐Dukie, S., Arora, D. S., Grant, G. D., McDermott, C., Perkins, A. V., & Davey, A. K. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151120607 · Cited by 199 · see citing works
SIRT1 in the brain—connections with aging-associated disorders and lifespan
Ng, F. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00064 · Cited by 185 · see citing works
Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine
Eid, A., Mhatre, I., & Richardson, J. R. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.03.005 · Cited by 164 · see citing works
Peters, D. G., Connor, J. R., & Meadowcroft, M. D. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.08.007 · Cited by 145 · see citing works
Emerging roles for cholesterol in Huntington's disease
Valenza, M., & Cattaneo, E. F. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.005 · Cited by 123 · see citing works
Statins and the Brain: More than Lipid Lowering Agents?
Fracassi, A., Marangoni, M., Rosso, P., Pallottini, V., Fioramonti, M., Siteni, S., & Segatto, M. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170703101816 · Cited by 116 · see citing works
Rojas‐Fernandez, C. H., & Cameron, J.-C. F. (2012) · Annals of Pharmacotherapy · doi:10.1345/aph.1q620 · Cited by 113 · see citing works
Harnessing endophenotypes and network medicine for Alzheimer's drug repurposing
Fang, J., Pieper, A. A., Nussinov, R., Lee, G., Bekris, L. M., Leverenz, J. B., Cummings, J. L., & Cheng, F. (2020) · Medicinal Research Reviews · doi:10.1002/med.21709 · Cited by 93 · see citing works
Lipid metabolism and neuroinflammation in Alzheimer’s disease: a role for liver X receptors
Kang, J., & Rivest, S. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1049 · Cited by 94 · see citing works
Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice
Matthews, D. G., Caruso, M., Murchison, C. F., Zhu, J. Y., Wright, K. M., Harris, C. J., Gray, N. E., Quinn, J. F., & Soumyanath, A. (2019) · Antioxidants · doi:10.3390/antiox8120630 · Cited by 86 · see citing works
“APP mouse models of AD demonstrate cognitive decline with pathology, comprising Aβ plaques closely associated with areas of high oxidative stress and dystrophic neurites [14,15].”
BackgroundUmeda, T., Tomiyama, T., Kitajima, E., Idomoto, T., Nomura, S., Lambert, M. P., Klein, W. L., & Mori, H. (2012) · Life Sciences · doi:10.1016/j.lfs.2011.12.022 · Cited by 78 · see citing works
Barone, E., Domenico, F. D., & Butterfield, D. A. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.10.030 · Cited by 79 · see citing works
Barone, E., Mancuso, C., Di Domenico, F., Sultana, R., Murphy, M. P., Head, E., & Butterfield, D. A. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07538.x · Cited by 75 · see citing works
Tramontina, A. C., Wartchow, K. M., Rodrigues, L., Biasibetti, R., Quincozes‐Santos, A., Bobermin, L. D., Tramontina, F. F., & Gonçalves, C. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0680-z · Cited by 72 · see citing works
Apolipoprotein A ‐ I : Insights from redox proteomics for its role in neurodegeneration
Keeney, J. T. R., Swomley, A. M., Förster, S., Harris, J. L., Rukhsana Sultana, A., & Butterfield, D. A. (2012) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201200087 · Cited by 73 · see citing works
Srivastava, S., & Haigis, M. C. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211798072526 · Cited by 69 · see citing works
A comprehensive review on the lipid and pleiotropic effects of pitavastatin
Sahebkar, A., Kiaie, N., Gorabi, A. M., Mannarino, M. R., Bianconi, V., Jamialahmadi, T., Pirro, M., & Banach, M. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101127 · Cited by 68 · see citing works
Pleiotropic effects of statins on brain cells
Sodero, A. O., & Barrantes, F. J. (2020) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2020.183340 · Cited by 66 · see citing works
MicroRNA-208a Increases Myocardial Fibrosis via Endoglin in Volume Overloading Heart
Wang, B. W., Wu, G., Cheng, W.-P., & Shyu, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084188 · Cited by 63 · see citing works
Statins and their influence on brain cholesterol
Cibičková, L. (2011) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2011.06.007 · Cited by 58 · see citing works
Chang, Y., Chiu, G.-F., Kuo, F., Lai, C., Yang, Y.-H., Hu, H., Chang, P., Chen, C., Wu, D., & Yu, F. (2013) · Gastroenterology Research and Practice · doi:10.1155/2013/175729 · Cited by 54 · see citing works
Zhai, Y., Yamashita, T., Nakano, Y., Sun, Z., Shang, J., Feng, T., Morihara, R., Fukui, Y., Ohta, Y., Hishikawa, N., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160345 · Cited by 54 · see citing works
Self-citationKurata, T., Miyazaki, K., Kozuki, M., Morimoto, N., Ohta, Y., Ikeda, Y., & Abe, K. (2012) · Neurological Research · doi:10.1179/1743132812y.0000000054 · Cited by 49 · see citing works
Self-citationCholesterol and Alzheimer's disease: A still poorly understood correlation
Ricciarelli, R., Canepa, E., Marengo, B., Marinari, U. M., Poli, G., Pronzato, M. A., & Domenicotti, C. (2012) · IUBMB Life · doi:10.1002/iub.1091 · Cited by 50 · see citing works
Pitavastatin decreases tau levels via the inactivation of Rho/ROCK
Hamano, T., Yen, S.-H., Gendron, T., Ko, L.-W., & Kuriyama, M. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.10.020 · Cited by 49 · see citing works
Neuroprotective effects of statins against amyloid β-induced neurotoxicity
Huang, C., Li, H., & Lin, C. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.226379 · Cited by 47 · see citing works
Kurata, T., Miyazaki, K., Morimoto, N., Kawai, H., Ohta, Y., Ikeda, Y., & Abe, K. (2013) · Neurological Research · doi:10.1179/1743132812y.0000000127 · Cited by 42 · see citing works
Self-citationNeurovascular and Cognitive failure in Alzheimer’s Disease: Benefits of Cardiovascular Therapy
Hamel, É., Royea, J., Ongali, B., & Tong, X. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0285-4 · Cited by 41 · see citing works
Adeli, S., Zahmatkesh, M., Tavoosidana, G., Karimian, M., & Hassanzadeh, G. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.09.009 · Cited by 41 · see citing works
Tradtrantip, L., Duan, T., Yeaman, M. R., & Verkman, A. S. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1448-x · Cited by 40 · see citing works
Mendoza‐Oliva, A., Zepeda, A., & Arias, C. (2014) · Current Alzheimer Research · doi:10.2174/1567205011666141001114858 · Cited by 35 · see citing works
Xu, C., Apostolova, L. G., Oblak, A. L., & Gao, S. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191023 · Cited by 35 · see citing works
Kozuki, M., Kurata, T., Miyazaki, K., Morimoto, N., Ohta, Y., Ikeda, Y., & Abe, K. (2011) · Brain Research · doi:10.1016/j.brainres.2011.03.024 · Cited by 34 · see citing works
Self-citationAre microRNAs the Molecular Link Between Metabolic Syndrome and Alzheimer’s Disease?
Codocedo, J. F., Ríos, J. A., Godoy, J. A., & Inestrosa, N. C. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9201-7 · Cited by 34 · see citing works
Examination of the FDA Warning for Statins and Cognitive Dysfunction
Sahebzamani, F. M. (2014) · Journal of Pharmacovigilance · doi:10.4172/2329-6887.1000141 · Cited by 30 · see citing works
Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes
Froestl, W., Muhs, A., & Pfeifer, A. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121537 · Cited by 31 · see citing works
Kurata, T., Kawai, H., Miyazaki, K., Kozuki, M., Morimoto, N., Ohta, Y., Ikeda, Y., & Abe, K. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.06.011 · Cited by 31 · see citing works
Self-citationLong-term Effect of Telmisartan on Alzheimer’s Amyloid Genesis in SHR-SR After tMCAO
Kurata, T., Lukic, V., Kozuki, M., Wada, D., Miyazaki, K., Morimoto, N., Ohta, Y., Deguchi, K., Yamashita, T., Hishikawa, N., et al. (2014) · Translational Stroke Research · doi:10.1007/s12975-013-0321-y · Cited by 31 · see citing works
Self-citationKurata, T., Miyazaki, K., Kozuki, M., Morimoto, N., Ohta, Y., Ikeda, Y., & Abe, K. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.030 · Cited by 30 · see citing works
Self-citationSelective benefits of simvastatin in bitransgenic APPSwe,Ind/TGF-β1 mice
Papadopoulos, P., Tong, X., & Hamel, É. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.010 · Cited by 26 · see citing works
Zhou, D., Liu, H., Li, C., Wang, F., Shi, Y., Liu, L., Zhao, X., Liu, A., Zhang, J., Wang, C., et al. (2016) · Metabolic Brain Disease · doi:10.1007/s11011-016-9803-4 · Cited by 26 · see citing works
Liu, X., Yamashita, T., Shang, J., Shi, X., Morihara, R., Huang, Y. C., Sato, K., Takemoto, M., Hishikawa, N., Ohta, Y., et al. (2019) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2019.03.029 · Cited by 25 · see citing works
Self-citationEffect of Atorvastatin and Rosuvastatin on Learning and Memory in Rats with Diazepam-Induced Amnesia
Georgieva-Kotetarova, M., & Kostadinova, I. I. (2013) · Folia Medica · doi:10.2478/folmed-2013-0018 · Cited by 24 · see citing works
Yi, P., Schrott, L. M., Castor, T. P., & Alexander, J. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9816-3 · Cited by 24 · see citing works
Roy, S., Weinstock, J. L., Ishino, A. S., Benites, J., Pop, S. R., Perez, C., Gumbs, E. A., Rosenbaum, J. A., Roccato, M. K., Shah, H., et al. (2017) · Journal of Clinical Medicine Research · doi:10.14740/jocmr3066w · Cited by 22 · see citing works
Hosaka, A., Araki, W., Oda, A., Tomidokoro, Y., & Tamaoka, A. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0956-1 · Cited by 22 · see citing works
Effects of HMG-CoA reductase inhibitors on learning and memory in the guinea pig
Maggo, S. D. S., & Ashton, J. C. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.11.018 · Cited by 21 · see citing works
Minh, T. N., Bedussi, B., Chasseigneaux, S., Dodacki, A., Yapo, C., Chacun, H., Scherrmann, J., Farinotti, R., & Bourasset, F. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121891 · Cited by 20 · see citing works
Cognitive Function Assessment in Patients on Moderate- or High-Intensity Statin Therapy
Roy, S., Hyman, D., Ayyala, S., Bakhshi, A., Kim, S. H., Anoruo, N., Weinstock, J. L., Balogun, A., D’Souza, M., Filatova, N., et al. (2020) · Journal of Clinical Medicine Research · doi:10.14740/jocmr4144 · Cited by 18 · see citing works
Tolédano, A., Rodríguez‐Casado, A., Álvarez, M., & Toledano‐Díaz, A. (2024) · Brain Sciences · doi:10.3390/brainsci14111101 · Cited by 19 · see citing works
Rayatnia, F., Paydar, M. J., Allami, N., Zakeri, M., Rastegar, H., Norouzi, A., & Dehpour, A. R. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.05.017 · Cited by 17 · see citing works
Watanabe, T., Yasutaka, Y., Nishioku, T., Nakashima, A., Futagami, K., Yamauchi, A., & Kataoka, Y. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.10.032 · Cited by 17 · see citing works
Sui, H., Zhang, L., Liu, Z., & Jin, Y. (2015) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.161 · Cited by 17 · see citing works
Coenzyme Q10 and cognition in atorvastatin treated dogs
Martin, S. B., Cenini, G., Barone, E., Dowling, A. L. S., Mancuso, C., Butterfield, D. A., Murphy, M. P., & Head, E. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.06.054 · Cited by 16 · see citing works
Feng, T., Yamashita, T., Shang, J., Shi, X., Nakano, Y., Morihara, R., Tsunoda, K., Nomura, E., Sasaki, R., Tadokoro, K., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190369 · Cited by 15 · see citing works
Self-citationEffects of Walnut Polyphenol on Learning and Memory Functions in Hypercholesterolemia Mice
Shi, D., Chen, C., Zhao, S., Ge, F., Liu, D., & Song, H. (2014) · Journal of Food and Nutrition Research · doi:10.12691/jfnr-2-8-4 · Cited by 15 · see citing works
Bian, Z., Liu, X., Feng, T., Yu, H., Hu, X. F., Hu, X., Bian, Y., Sun, H., Tadokoro, K., Takemoto, M., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215318 · Cited by 14 · see citing works
Self-citationThe calcium-free form of atorvastatin inhibits amyloid-β(1–42) aggregation in vitro
Nedaei, H., Rezaei‐Ghaleh, N., Giller, K., Becker, S., Karami, L., Moosavi‐Movahedi, A. A., Griesinger, C., & Moosavi‐Movahedi, A. A. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101662 · Cited by 14 · see citing works
Collu, R., Giunti, E., Daley, S. A., Chen, M., & Xia, W. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115756 · Cited by 14 · see citing works
Ahmed, M. A., & Kamel, E. O. (2020) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13457 · Cited by 12 · see citing works
Xu, G., Yang, L., Guan, P.-P., Wang, Z., & Wang, P. (2019) · Neurotherapeutics · doi:10.1007/s13311-018-00704-1 · Cited by 12 · see citing works
Wu, Y., Meng, W., Guan, M., Zhao, X., Zhang, C., Fang, Q., Zhang, Y., Sun, Z., Cai, M., Huang, D., et al. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.963083 · Cited by 12 · see citing works
Domenico, F. D., Marzia Perluigi, A., & Barone, E. (2013) · PubMed Central · doi:10.3969/j.issn.1673-5374.2013.21.001 · Cited by 11 · see citing works
Impact on Cognitive Function—Are All Statins the Same?
Shah, N. P., Swiger, K. J., & Martin, S. S. (2014) · Current Atherosclerosis Reports · doi:10.1007/s11883-014-0466-5 · Cited by 10 · see citing works
Wang, J., Cheng, X., Zhang, X., Liu, G., Wang, Y., Zhou, W., & Zhang, Y. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.03.003 · Cited by 8 · see citing works
Sun, M., Chen, W., Wu, S., & Zhang, J. (2023) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2023.11.010 · Cited by 7 · see citing works
Honarmand, A. R., Pourtabatabaei, N., Rahimi, N., Dehpour, A. R., & Paydar, M. J. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.03.023 · Cited by 7 · see citing works
Statin Therapy and the Development of Cerebral Amyloid Angiopathy—A Rodent in Vivo Approach
Reuter, B., Venus, A., Grudzenski, S., Heiler, P. M., Schad, L. R., Staufenbiel, M., Hennerici, M. G., & Fatar, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17010126 · Cited by 7 · see citing works
Protective Effects of Statins against Alzheimer Disease
Rezakhani, L., Salimi, Z., Zarei, F., Moradpour, F., Khazaei, M. R., Khazaei, M., & Pourjalili, M. (2023) · Ewha Medical Journal · doi:10.12771/emj.2023.e17 · Cited by 6 · see citing works
Artificial Intelligence based Modern Approaches to Diagnose Alzheimer s
Pai, R. V., & Wadhwa, A. (2022) · Indian Journal of Artificial Intelligence and Neural Networking · doi:10.54105/ijainn.b1045.022222 · Cited by 5 · see citing works
Feng, T., Hu, X., Fukui, Y., Bian, Z., Bian, Y., Sun, H., Takemoto, M., Yunoki, T., Nakano, Y., Morihara, R., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215246 · Cited by 5 · see citing works
Self-citationBian, Z., Yu, H., Hu, X., Bian, Y., Sun, H., Tadokoro, K., Takemoto, M., Yunoki, T., Nakano, Y., Fukui, Y., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220761 · Cited by 4 · see citing works
Self-citationStatins - From Lipid-Lowering Benefits to Pleiotropic Effects
Liu, D. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.1001540 · Cited by 4 · see citing works
El‐Sayyad, H. I., Amin, A. H., Ghawet, H. A. E., Al-Shahari, E. E., & Gebaly, A. E. (2016) · Journal of Molecular Biomarkers & Diagnosis · doi:10.4172/2155-9929.1000316 · Cited by 4 · see citing works
Atorvastatin enhances kainate‐induced gamma oscillations in rat hippocampal slices
Li, C., Wang, J., Zhao, J., Wang, Y., Liu, Z., Guo, F. L., Wang, X. F., Vreugdenhil, M., & Lu, C. B. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13322 · Cited by 4 · see citing works
Statins and Reduction of Oxidative Stress in the Aged Brain
Kurata, T., Deguchi, K., Deguchi, S., Ikeda, Y., & Abe, K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407824-6.00069-0 · Cited by 2 · see citing works
Self-citationStatin Use, Ageing, and Cognition: A Review
Stephenson, N. E., & Crowe, S. F. (2016) · Australian Psychologist · doi:10.1111/ap.12116 · Cited by 3 · see citing works
Park, Y., Lee, H. W., Ye, B. S., Kim, S. Y., & Yu, Y. M. (2025) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2025.101218 · Cited by 2 · see citing works
Role of centrally active cardiovascular agents in cognitive disorders
Theobald, R. J. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.05.001 · Cited by 2 · see citing works
Hu, X., Morihara, R., Fukui, Y., Bian, Y., Sun, H., Ota-Elliott, R. S., Ishiura, H., Abe, K., & Yamashita, T. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149752 · Cited by 1 · see citing works
Self-citationFeng, T., Chen, W., Bian, Z., Sun, H., & Shen, L. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251406645 · Cited by 1 · see citing works
Gider, V., & Budak, C. (2026) · Scientific Reports · doi:10.1038/s41598-026-35102-7 · Cited by 1 · see citing works
Golive, A., & Bunch, T. J. (2016) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2016.04.008 · Cited by 1 · see citing works
Guidelines for the treatment of dementia
Kurata, T., & Abe, K. (2014) · Okayama Igakkai Zasshi (Journal of Okayama Medical Association) · doi:10.4044/joma.126.155
Self-citationControversies over Statins-related Cognitive Impairment
INGOLE, S. A., Jain, R., & Tamboli, T. J. (2016) · International Journal of Cardiovascular and Cerebrovascular Disease · doi:10.13189/ijccd.2016.040202
A study of the global effects of Apolipoprotein E using lipidomics
Hawksworth, J. I. (2019) · ORCA Online Research @Cardiff (Cardiff University)
Statins’ Effects on Alzheimer’s Disease
Li, Q., Li, C.-N., & Chen, J. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.1001286
Fong, V., Kanuri, B., Traubert, O. D., Lui, M., & Patel, S. B. (2024) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02214-6
Statins as Neuroinflammatory Therapy, Bibliometric Study
Saleh, A. Y., Susanto, T. D., Valentina, R., & Saputra, D. A. Y. (2024) · F1000Research · doi:10.12688/f1000research.152963.1
Hanbouch, L. (2017) · theses.fr (ABES) · doi:10.70675/c4d2c894zf69dz4ae4z9ab1zf4135d0efa12
Rawal, P., Moon, H.-J., Nguyen, V., Khatri, S., Larson, M. A., Vivian, J. C., Saido, T. C., & Zhao, L. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.30.741791
- Authors
- Kurata, T., Miyazaki, K., Kozuki, M., Panin, V.-L., Morimoto, N., Ohta, Y., Nagai, M., Ikeda, Y., Matsuura, T., & Abe, K.
- Affiliations
- Okayama University (JP)
- Corresponding author
- Abe, Koji
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 1371
- Pages
- 161-170
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2044456875
- Cited by
- 98
- References
- 32
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 1 · 2020: 5 · 2019: 9 · 2018: 1 · 2017: 4 · 2016: 11 · 2015: 4 · 2014: 10 · 2013: 9 · 2012: 12
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Health, Labour and Welfare
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- atorvastatin, pitavastatin, statins, Alzheimer's disease, amyloid precursor protein transgenic mice, amyloid plaques, phosphorylated tau, dystrophic neurites, cognitive function, memory, amyloidosis, neuroprotection
- MeSH terms
- Atorvastatin, Aging, Alzheimer Disease, Animals, Body Weight, Brain, Cognition Disorders, Female, Heptanoic Acids, Humans, Lipids, Mice, Transgenic, Organ Size, Phosphorylation, Protein Processing, Post-Translational, Pyrroles, Quinolines, Amyloid beta-Protein Precursor, tau Proteins, Neuroprotective Agents, Maze Learning, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Mice, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review