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Cited by 277

The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.

Fatty acids in cardiovascular health and disease: A comprehensive update

Open access
Baum, Seth J., Kris-Etherton, Penny M., Willett, Walter C., Lichtenstein, Alice H., Rudel, Lawrence L., Maki, Kevin C., Whelan, Jay, Ramsden, Christopher E., Block, Robert C.·2012·Journal of Clinical Lipidology

Abstract

Research dating back to the 1950s reported an association between the consumption of saturated fatty acids (SFAs) and risk of coronary heart disease. Recent epidemiological evidence, however, challenges these findings. It is well accepted that the consumption of SFAs increases low-density lipoprotein cholesterol (LDL-C), whereas carbohydrates, monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids (PUFAs) do not. High-density lipoprotein (HDL)-C increases with SFA intake. Among individuals who are insulin resistant, a low-fat, high-carbohydrate diet typically has an adverse effect on lipid profiles (in addition to decreasing HDL-C, it also increases triglyceride and LDL particle concentrations). Consequently, a moderate fat diet in which unsaturated fatty acids replace SFAs and carbohydrates are not augmented is advised to lower LDL-C; compared with a low-fat diet, a moderate-fat diet will lower triglycerides and increase HDL-C. Now, there is some new evidence that is questioning the health benefits of even MUFAs and PUFAs. In addition, in a few recent studies investigators have also failed to demonstrate expected cardiovascular benefits of marine-derived omega-3 fatty acids. To clarify the clinical pros and cons of dietary fats, the National Lipid Association held a fatty acid symposium at the 2011 National Lipid Association Scientific Sessions. During these sessions, the science regarding the effects of different fatty acid classes on coronary heart disease risk was reviewed.

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Crossref · 10.1016/j.jacl.2012.04.077

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Metadata

Authors
Baum, S. J., Kris-Etherton, P. M., Willett, W. C., Lichtenstein, A. H., Rudel, L. L., Maki, K. C., Whelan, J., Ramsden, C. E., & Block, R. C.
Venue
Journal of Clinical Lipidology
Publisher
Elsevier BV
Published
2012-05
Volume
6
Issue
3
Pages
216-234
ISSN
  • 1876-4789 (ISSN-L)
  • 1933-2874
OpenAlex
W1970693723
Cited by
277
References
95
FWCI
28.69
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Fatty acids in cardiovascular health and disease: A comprehensive update. https://app.cochat.ai/papers/10.1016/j.jacl.2012.04.077
The paper
Baum, S. J., Kris-Etherton, P. M., Willett, W. C., Lichtenstein, A. H., Rudel, L. L., Maki, K. C., Whelan, J., Ramsden, C. E., & Block, R. C. (2012). Fatty acids in cardiovascular health and disease: A comprehensive update. Journal of Clinical Lipidology. https://doi.org/10.1016/j.jacl.2012.04.077

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.