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Cited by 38Treatment of Major DepressionPsychotherapy Techniques and ApplicationsAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Optimal duration of combined psychotherapy and pharmacotherapy for patients with moderate and severe depression: A meta-analysis

Oestergaard, Svetlana, Møldrup, Claus·2011·Journal of Affective Disorders
DOI 10.1016/j.jad.2010.08.014
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Abstract

Background To investigate the most effective duration of combined psychotherapy and pharmacotherapy for achieving remission and preventing relapse in depressive patients as compared to pharmacotherapy alone. Methods A systematic review of English articles using PubMed, EMBASE, Web of Science, the Cochrane Library, and PsychINFO was performed in September 2009. Clinical studies comparing pharmacotherapy alone with pharmacotherapy in combination with a psychological intervention for depression treatment that reported response, remission or relapse as outcomes were included in the analysis. For each of the studies, clinical binary outcomes such as response, remission or relapse were extracted. Results All pooled analyses were based on random-effects models. Twenty-one article describing the influence of additional psychotherapy on remission and 15 articles reporting the influence on relapse in depression were included in the analysis. Patients receiving combined treatment experienced remission more often than those receiving pharmacotherapy alone, with the highest odds ratio OR, 2.36; 95% CI, 1.58-3.55 observed at 4months after commencing the treatment. Patients receiving pharmacotherapy alone also demonstrated a higher risk for relapse compared to those receiving combined treatment. Limitations We restricted our search to only English language publications. Studies investigating relapse or recurrence rates are often of small size. Conclusion Pharmacotherapy enhanced with psycho…

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  • The odds of remission are higher with combined treatment for depression than with pharmacotherapy alone, with the highest odds ratio 2.36 after four months.

    “For example, the odds of achieving remission is higher with combined treatment for depression relative to pharmacotherapy alone (with the highest odds ratio of 2.36 after 4 months of treatment; Oestergaard & Møldrup, 2011)”

    From An Integrated, Acceptance-Based Behavioral Approach for Depression With Social Anxiety: Preliminary Results (2014) · cites this paper as Oestergaard & Møldrup, 2011

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Authors
Oestergaard, S., & Møldrup, C.
Affiliations
University of Copenhagen (DK)
Corresponding author
Oestergaard, Svetlana
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2011-06
Volume
131
Issue
1-3
Pages
24-36
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/j.jad.2010.08.014
OpenAlex
W1981734024
Cited by
38
References
17
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 8 · 2014: 6 · 2013: 3 · 2012: 5
FWCI
0.40
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
depression, combined psychotherapy and pharmacotherapy, antidepressants, treatment duration, remission, relapse prevention, moderate to severe depression, continuation phase, acute phase
MeSH terms
Antidepressive Agents, Combined Modality Therapy, Depressive Disorder, Humans, Psychotherapy, Remission Induction, Time Factors, Confidence Intervals, Odds Ratio, Treatment Outcome, Secondary Prevention

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