Efficacy of Interpersonal Psychotherapy plus pharmacotherapy in chronically depressed inpatients
Abstract
Background Clinical guidelines recommend the combination of pharmaco- and psychotherapy for the treatment of chronic depression, although there are only a few studies supporting an additive effect of psychotherapy. Methods Forty-five inpatients with a chronic Major Depressive Disorder were randomized to 5 weeks of either Interpersonal Psychotherapy (IPT) modified for an inpatient setting (15 individual and 8 group sessions) plus pharmacotherapy or to medication plus Clinical Management (CM). The 17-item Hamilton Rating Scale for Depression was the primary outcome measure. The study included a prospective naturalistic follow-up, 3- and 12-months after discharge. Results Intent-to-treat analyses revealed a significantly greater reduction of depressive symptoms as well as better global functioning of patients treated with IPT compared to the CM group at week 5. Response and sustained response rates differed significantly between the two treatment conditions, favouring the IPT group. Remission rates were considerably higher for IPT patients who completed the treatment (67% vs. 32%). Patients who initially responded to IPT exhibited greater treatment gains at 12 months since only 7% of these subjects relapsed compared with 25% of the CM subjects. In the long-term, additional IPT led to a lower symptom level and higher global functioning. Limitations The study uses data of a subset of patients from a larger trial. Both treatment groups did not receive comparable amounts of therapeutic attention. Extrapolating the data from this inpatient study to chronically depressed outpatients may not be possible. Conclusions Intensive combined treatment provides superior acute and long-term effects over standard treatment in chronically depressed inpatients.
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IPT is considered a leading psychotherapeutic treatment for depression.
“IPT is considered a leading psychotherapeutic treatment for depression (Cuijpers, van Straten, Andersson, & van Oppen, 2008; de Mello, de Jesus Mari, Bacaltchuk, Verdeli, & Neugebauer, 2005; Schramm et al., 2008).”
From Sudanese Refugees in Cairo, Egypt: A Randomized Controlled Trial of Interpersonal Psychotherapy for Trauma, Depression and Interpersonal Violence: (517292011-807) (2009) · cites this paper as Schramm et al., 2008
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GeneralizabilityofFindingsFrom EfficacyTrialsforChronicDepression: AnAnalysisofEligibilityCriteria
von Wolff, A., Hölzel, L. P., & Härter, M. C. (2014)
Self-citationOutcomes in the Treatment of Major Depressive Disorder
Thase, M. E., & Koenig, A. M. (2009) · doi:10.3109/9781420084887-4
Chopra, K. K. (2013) · TSpace (University of Toronto)
Les thérapies interpersonnelles et la dépression de la personne âgée
L’Hégaret, Y., Hamida, M. C.-B., Guillard, V., Boële, A., Lemarié, C., Didillon, A., & Neveux, N. (2018) · NPG. Neurologie, psychiatrie, gériatrie/NPG · doi:10.1016/j.npg.2018.07.005
Köhler, S., Sterzer, P., Normann, C., Berger, T., & Brakemeier, E. (2016) · Der Nervenarzt
(2012) · Elsevier eBooks · doi:10.1016/b978-0-323-08373-7.00013-3
Grundlagen der Diagnostik und Therapie
(2024) · Elsevier eBooks · doi:10.1016/b978-3-437-22487-4.16001-0
- Authors
- Schramm, E., Schneider, D., Zobel, I., van Calker, D., Dykierek, P., Kech, S., Härter, M., & Berger, M.
- Affiliations
- University of Freiburg (DE)
- Corresponding author
- Schramm, Elisabeth
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 109
- Issue
- 1-2
- Pages
- 65-73
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2168396056
- Cited by
- 88
- References
- 34
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 7 · 2015: 5 · 2014: 5 · 2013: 10 · 2012: 10
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- interpersonal psychotherapy, chronic depression, major depressive disorder, inpatient care, pharmacotherapy, combined psychotherapy and pharmacotherapy, clinical management, remission, relapse, global functioning, long-term outcomes
- MeSH terms
- Adolescent, Adult, Aged, Amitriptyline, Antidepressive Agents, Chronic Disease, Combined Modality Therapy, Major Depressive Disorder, Drug Administration Schedule, Female, Follow-Up Studies, Hospitalization, Humans, Male, Middle Aged, Prospective Studies, Psychotherapy, Group, Treatment Outcome, Sertraline
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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