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Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts
Open accessAbstract
Background Anecdotal reports of mood disorder following infection with common respiratory viruses with neurotropic potential have been in existence since the last century. Nevertheless, systematic studies on the association between these viruses and mood disorders are lacking.Methods Influenza A, B and coronavirus antibody titers were measured in 257 subjects with recurrent unipolar and bipolar disorder and healthy controls, by SCID. Pearson's χ² tests and logistic regression models were used to analyze associations between seropositivity for coronaviruses, influenza A and B viruses and the following: a) history of recurrent mood disorders b) having attempted suicide in the past c) uni- vs. bi-polarity and d) presence of psychotic symptoms during mood episodes.Results Seropositivity for influenza A (p=0.004), B (p<0.0001) and coronaviruses (p<0.0001) were associated with history of mood disorders but not with the specific diagnosis of unipolar or bipolar depression. Seropositivity for influenza B was significantly associated with a history of suicide attempt (p=0.001) and history of psychotic symptoms (p=0.005).Limitations The design was cross-sectional. Socioeconomic factors, inflammatory markers, and axis II psychopathology were not assessed.Conclusions The association of seropositivity for influenza and coronaviruses with a history of mood disorders, and influenza B with suicidal behavior require replication in larger longitudinal samples. The need for these studies is additionally supported by the high incidence of these viral infections, the high prevalence of mood disorders, and resilience of suicide epidemics.
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“Moreover, seropositivity for coronaviruses associated with suicide and psychosis persisting one year after SARS (Okusaga et al., 2011).”
From Anxiety and depression in COVID-19 survivors: role of inflammatory and clinical predictors (2020) · cites this paper as Okusaga et al., 2011
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“Further indication for psychiatric implications of coronaviruses infections came from a study of Okusaga et al. [160], who connected seropositivity for human coronavirus strain L63 with mood disorders and suicide attempts.”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [160]
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Metadata
- Authors
- Okusaga, O., Yolken, R. H., Langenberg, P., Lapidus, M., Arling, T. A., Dickerson, F. B., Scrandis, D. A., Severance, E., Cabassa, J. A., Balis, T., & Postolache, T. T.
- Affiliations
- University of Maryland, Baltimore (US)
- Johns Hopkins University (US)
- Sheppard Pratt Health System (US)
- Corresponding author
- Postolache, Teodor T.
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 130
- Issue
- 1-2
- Pages
- 220-225
- ISSN
- 0165-0327 (ISSN-L)
- PMC
- PMC3043161
- OpenAlex
- W1965020733
- Cited by
- 163
- References
- 55
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 29 · 2021: 36 · 2020: 44 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Affective Disorders (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH074891, R21MH075891)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Keywords
- influenza A virus, influenza B, coronavirus, seropositivity, mood disorders, bipolar disorder, major depressive disorder, suicide attempts, psychotic symptoms, neurotropic viruses
- MeSH terms
- Adolescent, Adult, Aged, Bipolar Disorder, Major Depressive Disorder, Depressive Disorder, Female, Humans, Influenza, Human, Male, Middle Aged, Influenza A virus, Influenza B virus, Suicide, Attempted, Chi-Square Distribution, Logistic Models, Coronavirus, Coronavirus Infections, Mood Disorders, Young Adult
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