The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts
Open accessAbstract
Background Anecdotal reports of mood disorder following infection with common respiratory viruses with neurotropic potential have been in existence since the last century. Nevertheless, systematic studies on the association between these viruses and mood disorders are lacking.Methods Influenza A, B and coronavirus antibody titers were measured in 257 subjects with recurrent unipolar and bipolar disorder and healthy controls, by SCID. Pearson's χ² tests and logistic regression models were used to analyze associations between seropositivity for coronaviruses, influenza A and B viruses and the following: a) history of recurrent mood disorders b) having attempted suicide in the past c) uni- vs. bi-polarity and d) presence of psychotic symptoms during mood episodes.Results Seropositivity for influenza A (p=0.004), B (p<0.0001) and coronaviruses (p<0.0001) were associated with history of mood disorders but not with the specific diagnosis of unipolar or bipolar depression. Seropositivity for influenza B was significantly associated with a history of suicide attempt (p=0.001) and history of psychotic symptoms (p=0.005).Limitations The design was cross-sectional. Socioeconomic factors, inflammatory markers, and axis II psychopathology were not assessed.Conclusions The association of seropositivity for influenza and coronaviruses with a history of mood disorders, and influenza B with suicidal behavior require replication in larger longitudinal samples. The need for these studies is additionally supported by the high incidence of these viral infections, the high prevalence of mood disorders, and resilience of suicide epidemics.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, seropositivity for coronaviruses associated with suicide and psychosis persisting one year after SARS (Okusaga et al., 2011).”
From Anxiety and depression in COVID-19 survivors: role of inflammatory and clinical predictors (2020) · cites this paper as Okusaga et al., 2011
In the citing paper
“Further indication for psychiatric implications of coronaviruses infections came from a study of Okusaga et al. [160], who connected seropositivity for human coronavirus strain L63 with mood disorders and suicide attempts.”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [160]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Harrison's principles of internal medicine
(2008) · Choice Reviews Online · doi:10.5860/choice.46-0330 · Cited by 3,072
Harrison's Principles of Internal Medicine.
(1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-100-1-167_1 · Cited by 1,527
Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones
Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986) · Science · doi:10.1126/science.3014662 · Cited by 1,519
The role of corticotropin-releasing factor in depression and anxiety disorders
Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600001 · Cited by 1,378
Neurobiology of suicidal behaviour
Mann, J. J. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1220 · Cited by 1,260
Cytokine-induced sickness behavior: where do we stand?
Dantzer, R. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2000.0613 · Cited by 862
Nicholson, K. G., Wood, J., & Zambon, M. C. F. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14854-4 · Cited by 696
Beautrais, A. L., Joyce, P. R., Mulder, R. T., Fergusson, D. M., Deavoll, B. J., & Nightingale, S. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.8.1009 · Cited by 654
Gelder, M. (1983) · Cited by 557
Neuroinvasion by Human Respiratory Coronaviruses
Arbour, N., Day, R. W., Newcombe, J., & Talbot, P. J. (2000) · Journal of Virology · doi:10.1128/jvi.74.19.8913-8921.2000 · Cited by 526
Interferon-alpha–induced changes in tryptophan metabolism
Capuron, L., Neurauter, G., Musselman, D. L., Lawson, D. H., Nemeroff, C. B., Fuchs, D., & Miller, A. H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00173-2 · Cited by 493
Xu, J., Zhong, S., Liu, J., Li, L., Li, Y., Wu, X., Li, Z., Deng, P., Zhang, J., Zhong, N. S., et al. (2005) · Clinical Infectious Diseases · doi:10.1086/444461 · Cited by 492
Organic Psychiatry: The Psychological Consequences of Cerebral Disorder
Lishman, W. (1978) · Cited by 483
Measuring the global burden of disease and epidemiological transitions: 2002–2030
López, A. D., & Mathers, C. D. (2006) · Annals of Tropical Medicine and Parasitology · doi:10.1179/136485906x97417 · Cited by 462
Licinio, J., & Wong, M.-L. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000586 · Cited by 380
Jawetz, Melnick & Adelberg's Medical Microbiology
Brooks, G. F. (2001) · Cited by 377
The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans
Wichers, M., & Maes, M. (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702003103 · Cited by 329
Yeh, E. A., Collins, A. R., Cohen, M. E., Duffner, P. K., & Faden, H. S. (2004) · PEDIATRICS · doi:10.1542/peds.113.1.e73 · Cited by 329
Seasonal Patterns of Stress, Immune Function, and Disease
Nelson, R. J., Demas, G. E., Klein, S. L., Kriegsfeld, L. J., & Bronson, F. H. (2002) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546341 · Cited by 316
Cytokines as modulators of the hypothalamus-pituitary-adrenal axis
Besedovsky, H. O., Del Rey, A., Klusman, I., Furukawa, H., Monge Arditi, G., & Kabiersch, A. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90284-c · Cited by 314
Review of Medical Microbiology and Immunology
Levinson, W. E. (2002) · Repository of the University of Ljubljana (University of Ljubljana) · Cited by 256
Dictionary of Psychological Medicine
WOK (1893) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-189309000-00024 · Cited by 227
PCR on cerebrospinal fluid to show influenza-associated acute encephalopathy or encephalitis
Fujimoto, S., Kobayashi, M., Uemura, O., Iwasa, M., 安藤, 恒., Katoh, T., Nakamura, C., Maki, N., Togari, H., & Wada, Y. (1998) · The Lancet · doi:10.1016/s0140-6736(98)12449-2 · Cited by 227
Gold, P. W., Licinio, J., Wong, M., & Chrousos, G. P. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44723.x · Cited by 199
Coronavirus Immunoreactivity in Individuals With a Recent Onset of Psychotic Symptoms
Severance, E. G., Dickerson, F., Viscidi, R. P., Bossis, I., Stallings, C. R., Origoni, A. E., Sullens, A., & Yolken, R. H. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp052 · Cited by 196
Self-citationDeterminants and Outcomes of Serious Attempted Suicide: A Nationwide Study in Finland, 1996-2003
Haukka, J. K., Suominen, K. H., Partonen, T., & Lönnqvist, J. K. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn017 · Cited by 194
Organic Psychiatry The Psychological Consequences of Cerebral Disorder
Durward, W. F. (1979) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.42.8.772-a · Cited by 168
Capuron, L., Fornwalt, F. B., Knight, B. T., Harvey, P. D., Ninan, P. T., & Miller, A. H. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.02.017 · Cited by 164
Mouse interleukin-6 stimulates the HPA axis and increases brain tryptophan and serotonin metabolism
Wang, J., & Dunn, A. J. (1998) · Neurochemistry International · doi:10.1016/s0197-0186(98)00016-3 · Cited by 144
dictionary of psychological medicine
Tuke, D. H. (2016) · Medical Entomology and Zoology · Cited by 139
Brain-immune interactions and disease susceptibility
Marques-Deak, A., Cizza, G., & Sternberg, E. M. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001643 · Cited by 134
Hiroi, N., Wong, M. L., Licinio, J., Park, C., Young, M., Gold, P. W., Chrousos, G. P., & Bornstein, S. R. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000908 · Cited by 124
Ellman, L. M., Yolken, R. H., Buka, S. L., Torrey, E. F., & Cannon, T. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.12.015 · Cited by 116
Self-citationShorter Oxford Textbook of Psychiatry
Ford, P. (2011) · Occupational Medicine · doi:10.1093/occmed/kqq186 · Cited by 114
Postolache, T. T., Mortensen, P. B., Tonelli, L. H., Jiao, X., Frangakis, C., Soriano, J. J., & Qin, P. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.05.015 · Cited by 106
Self-citationSeverance, E. G., Bossis, I., Dickerson, F., Stallings, C. R., Origoni, A. E., Sullens, A., Yolken, R. H., & Viscidi, R. P. (2008) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00124-08 · Cited by 101
Self-citationInfluenza B Virus Encephalitis
McCullers, J. A., Facchini, S., Chesney, P. J., & Webster, R. G. (1999) · Clinical Infectious Diseases · doi:10.1086/515214 · Cited by 93
Azorin, J., Kaladjian, A., Besnier, N., Adida, M., Hantouche, E. G., Lancrenon, S., & Akiskal, H. S. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.09.004 · Cited by 82
Orthomyxoviruses (influenza viruses)
Hermodsson, S. (1983) · Elsevier eBooks · doi:10.1016/b978-0-407-00253-1.50032-3 · Cited by 52
Acute sickness behaviour: an immune system-to-brain communication?
Vollmer-Conna, U. S. (2001) · Psychological Medicine · doi:10.1017/s0033291701003841 · Cited by 52
Coronaviruses in brain tissue from patients with multiple sclerosis
Dessau, R. B., Lisby, G., & Frederiksen, J. L. (2001) · Acta Neuropathologica · doi:10.1007/s004010000331 · Cited by 51
Skok, M. V. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0209106 · Cited by 48
Airborne inflammatory factors from the nose to the brain
Tonelli, L. H. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s52 · Cited by 47
The widening scope of coronaviruses
Kahn, J. S. (2006) · Current Opinion in Pediatrics · doi:10.1097/01.mop.0001110940.57894.90 · Cited by 46
Influenza Infection Causing Manic Psychosis
Steinberg, D., Hirsch, S. R., Marston, S. D., Reynolds, K., & Sutton, R. N. P. (1972) · The British Journal of Psychiatry · doi:10.1192/bjp.120.558.531 · Cited by 44
An exploratory approach to the serotonergic hypothesis of depression: bridging the synaptic gap
Dursun, S. M., Blackburn, J., & Kutcher, S. (2001) · Medical Hypotheses · doi:10.1054/mehy.2000.1187 · Cited by 32
Reversible Splenial Lesion in Influenza Virus Encephalopathy
Matsubara, K., Kodera, M., Nigami, H., Yura, K., & Fukaya, T. (2007) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2007.08.008 · Cited by 29
Host-pathogen interactions during coronavirus infection of primary alveolar epithelial cells
Miura, T. A., & Holmes, K. V. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0209078 · Cited by 25
Influenza and Mania: A Possible Connection With the Locus Ceruleus
MAURIZI, C. P. (1985) · Southern Medical Journal · doi:10.1097/00007611-198502000-00025 · Cited by 24
Harrison, R. M. (1958) · BMJ · doi:10.1136/bmj.1.5068.460 · Cited by 15
The Neurology of Affective Disorder and Suicide
Whitlock, F. A. (1982) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048678209159465 · Cited by 15
M-Protein as a Possible Inducer of Depressive State in Influenza
Zhilinskaya, I. N., Маклакова, А. С., & Ашмарин, И. П. (2002) · Doklady Biological Sciences · doi:10.1023/a:1021749810319 · Cited by 2
Shorter Oxford Textbook of Psychiatry
Harrison, P., Cowen, P., Fazel, M., & Bhui, K. (2026) · Oxford University Press eBooks · doi:10.1093/med/9780192871053.001.0001
Cited by
Sorted by citations
Fegert, J. M., Vitiello, B., Plener, P. L., & Clemens, V. (2020) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-020-00329-3 · Cited by 1,807
Anxiety and depression in COVID-19 survivors: role of inflammatory and clinical predictors
Mazza, M. G., De Lorenzo, R., Conte, C., Poletti, S., Vai, B., Bollettini, I., Melloni, E. M. T., Furlan, R., Ciceri, F., Rovere-Querini, P., et al. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.07.037 · Cited by 1,804
Troyer, E. A., Kohn, J. N., & Hong, S. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.04.027 · Cited by 964
Autoimmune Diseases and Severe Infections as Risk Factors for Mood Disorders: A Nationwide Study
Benros, M. E., Waltoft, B. L., Nordentoft, M., Østergaard, S. D., Eaton, W. W., Krogh, J., & Mortensen, P. B. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1111 · Cited by 572
Consideraciones sobre la salud mental en la pandemia de COVID-19
Huarcaya-Victoria, J. (2020) · Revista Peruana de Medicina Experimental y Salud Pública · doi:10.17843/rpmesp.2020.372.5419 · Cited by 496
Metadata
- Authors
- Okusaga, O., Yolken, R. H., Langenberg, P., Lapidus, M., Arling, T. A., Dickerson, F. B., Scrandis, D. A., Severance, E., Cabassa, J. A., Balis, T., & Postolache, T. T.
- Affiliations
- University of Maryland, Baltimore (US)
- Johns Hopkins University (US)
- Sheppard Pratt Health System (US)
- Corresponding author
- Postolache, Teodor T.
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 130
- Issue
- 1-2
- Pages
- 220-225
- ISSN
- 0165-0327 (ISSN-L)
- PMC
- PMC3043161
- OpenAlex
- W1965020733
- Cited by
- 163
- References
- 55
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 29 · 2021: 36 · 2020: 44 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Affective Disorders (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH074891, R21MH075891)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Keywords
- influenza A virus, influenza B, coronavirus, seropositivity, mood disorders, bipolar disorder, major depressive disorder, suicide attempts, psychotic symptoms, neurotropic viruses
- MeSH terms
- Adolescent, Adult, Aged, Bipolar Disorder, Major Depressive Disorder, Depressive Disorder, Female, Humans, Influenza, Human, Male, Middle Aged, Influenza A virus, Influenza B virus, Suicide, Attempted, Chi-Square Distribution, Logistic Models, Coronavirus, Coronavirus Infections, Mood Disorders, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
