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Cited by 48Bipolar Disorder and TreatmentSuicide and Self-Harm StudiesSchizophrenia research and treatment

The 5-HTTLPR polymorphism, impulsivity and suicide behavior in euthymic bipolar patients

Malloy-Diniz, Leandro Fernandes, Neves, Fernando Silva, de Moraes, Paulo Henrique Paiva, De Marco, Luiz Armando, Romano-Silva, Marco Aurélio, Krebs, Marie-Odile, Corrêa, Humberto·2011·Journal of Affective Disorders
DOI 10.1016/j.jad.2011.03.051
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Abstract

Background Suicide behavior is very frequent in Bipolar Disorder (BD) and they are both closely associated with impulsivity. Furthermore they are, impulsivity, BD and suicide behavior, associated with serotonergic function, at least partially, under genetic determinism and somewhat associated with the serotonin transporter gene polymorphism, the 5-HTTLPR. We aimed to assess different impulsivity components in BD sub-grouped by suicidal attempt and healthy controls. We hypothesized that the non-planning/cognitive impulsivity, could be more closely associated with suicidal behavior. We further associated 5-HTTLPR genotypes with neuropsychological results to test the hypothesis that this polymorphism is associated with cognitive impulsivity. Method We assessed 95 euthymic bipolar patients sub-grouped by suicidal attempt history in comparison with 94 healthy controls. All subjects underwent a laboratory assessment of impulsivity (Continuous Performance Test and Iowa Gambling Test). Furthermore the genotyping of 5-HTTLPR was performed in all subjects. Results We found that bipolar patients are more impulsive than healthy controls in all impulsivity dimensions we studied. Furthermore bipolar patients with a suicide attempt history have a greater cognitive impulsivity when compared to both bipolar patients without such a history as well when compared to healthy controls. No association was found between 5-HTTLPR genotypes and neuropsychological measures of impulsive behavior. Limita…

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Sorted by citations

Authors
Malloy-Diniz, L. F., Neves, F. S., de Moraes, P. H. P., De Marco, L. A., Romano-Silva, M. A., Krebs, M.-O., & Corrêa, H.
Affiliations
  • Universidade Federal de Minas Gerais (BR)
  • Inserm (FR)
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2011-09
Volume
133
Issue
1-2
Pages
221-226
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/j.jad.2011.03.051
OpenAlex
W2000585395
Cited by
48
References
6
Citations by year
2025: 3 · 2024: 1 · 2022: 3 · 2021: 4 · 2020: 4 · 2018: 1 · 2017: 7 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 7 · 2012: 2
FWCI
2.92
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • CNPq
  • MCT
  • FAPEMIG (SHA-APQ-00741-09)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
bipolar disorder, suicide attempts, impulsivity, cognitive impulsivity, 5-HTTLPR polymorphism, serotonin transporter gene, euthymic bipolar patients, Iowa Gambling Task, continuous performance test, neuropsychological assessment, genetic association
MeSH terms
Adult, Bipolar Disorder, Cyclothymic Disorder, Female, Genotype, Humans, Impulsive Behavior, Iowa, Male, Middle Aged, Polymorphism, Genetic, Promoter Regions, Genetic, Suicide, Suicide, Attempted, Serotonin Plasma Membrane Transport Proteins, Suicidal Ideation

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