The DOI matches its Crossref record; 196 of the 201 references it cites were found in a registry or an index.
Complementary and alternative therapies as add-on to pharmacotherapy for mood and anxiety disorders: A systematic review
Abstract
Background Depressed and anxious patients often combine complementary and alternative medicine (CAM) therapies with conventional pharmacotherapy to self-treat symptoms. The benefits and risks of such combination strategies have not been fully evaluated. This paper evaluates the risk-benefit profile of CAM augmentation to antidepressants in affective conditions.Methods PubMed was searched for all available clinical reports published in English up to December 2012. Data were evaluated based on graded levels of evidence for efficacy and safety.Results Generally, the evidence base is significantly larger for depression than for anxiety disorder. In unipolar depression, there is Level 2 evidence for adjunctive sleep deprivation (SD) and Free and Easy Wanderer Plus (FEWP), and Level 3 for exercise, yoga, light therapy (LT), omega-3 fatty acids, S-adenosylmethionine and tryptophan. In bipolar depression, there is Level 1 evidence for adjunctive omega-3s, Level 2 for SD, and Level 3 for LT and FEWP. In anxiety conditions, exercise augmentation has Level 3 support in generalized anxiety disorder and panic disorder. Though mostly well-tolerated, these therapies can only be recommended as third-line interventions due to the quality of available evidence.Limitations Overall, the literature is limited. Studies often had methodological weaknesses, with little information on long-term use and on potential drug-CAM interactions. Many CAM studies were not published in English.Conclusions While several CAM therapies show some evidence of benefit as augmentation in depressive disorders, such evidence is largely lacking in anxiety disorders. The general dearth of adequate safety and tolerability data encourages caution in clinical use.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“We found that participants in the Seduction of Spirit meditation course experienced a greater reduction in depressed mood scores compared to the other courses, which supports previous data on the beneficial effects of meditation specifically on depression.34”
From Psychosocial Effects of a Holistic Ayurvedic Approach to Well-being in Health and Wellness Courses (2019) · cites this paper as [34]
Citations
Cites
1 retracted
Bright Light Treatment as Add-On Therapy for Depression in 28 Adolescents
Niederhofer, H. (2011) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.11m01194 · Cited by 32
RetractedPharmacological interventions for somatoform disorders in adults
Kleinstäuber, M., Witthöft, M., Steffanowski, A., van Marwijk, H., Hiller, W., & Lambert, M. J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010628.pub2 · Cited by 11,369
The burden of oral disease: challenges to improving oral health in the 21st century.
Petersen, P. E. (2005) · Europe PMC (PubMed Central) · Cited by 3,575
Yatham, L. N., & Malhi, G. S. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780199562305.001.0001 · Cited by 3,515
Effects of exercise training on older patients with major depression
Blumenthal, J. A., Babyak, M. A., Moore, K. A., Craighead, W. E., Herman, S., Khatri, P., Waugh, R., Napolitano, M. A., Forman, L. M., Appelbaum, M., et al. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.19.2349 · Cited by 1,277 · cited 1×
“Interestingly, in one of these studies, onset of improvement was fastest with medication alone (Blumenthal et al., 1999), but at 6-month follow-up, depression was lower and relapse and remission higher with exercise alone (Babyak et al.”
BackgroundPhysical activity, exercise, depression and anxiety disorders
Ströhle, A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-008-0092-x · Cited by 1,269
Sequenced treatment alternatives to relieve depression (STAR*D): Rationale and design
Rush, A. J., Fava, M., Wisniewski, S. R., Lavori, P. W., Trivedi, M. H., Sackeim, H. A., Thase, M. E., Nierenberg, A. A., Quitkin, F. M., Kashner, T. M., et al. (2004) · Controlled Clinical Trials · doi:10.1016/s0197-2456(03)00112-0 · Cited by 1,076
Exercise Treatment for Major Depression: Maintenance of Therapeutic Benefit at 10 Months
Babyak, M., Blumenthal, J. A., Herman, S., Khatri, P., Doraiswamy, M., Moore, K., Edward Craighead, W., Baldewicz, T. T., & Ranga Krishnan, K. (2000) · Psychosomatic Medicine · doi:10.1097/00006842-200009000-00006 · Cited by 1,063
Thompson (2007) · doi:10.1161/circulationaha.107.181485 · Cited by 1,000
Golden, R. N., Gaynes, B. N., Ekstrom, R. D., Hamer, R. M., Jacobsen, F. M., Suppes, T., Wisner, K. L., & Nemeroff, C. B. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.4.656 · Cited by 896 · cited 1×
“, 2008), while two meta-analyses did not (Golden et al., 2005; Tuunainen et al., 2004).”
Result
Research works printed but not linked: 3
- Alonso, 2007, Overview of key data from the European study of the epidemiology of mental disorders (ESEMeD), Journal of Clinical Psychiatry, 68, 3
- Chan, 1994, Mania precipitated by light therapy for patients with SAD (letter), Journal of Clinical Psychiatry, 55, 454
- World Health Organization (WHO), 2000, Cross-national comparisons of the prevalences and correlates of mental disorders, Bulletin of the World Health Organization, 78, 413
Cited by
Sorted by citations
Rebar, A. L., Stanton, R., Geard, D., Short, C., Duncan, M. J., & Vandelanotte, C. (2015) · Health Psychology Review · doi:10.1080/17437199.2015.1022901 · Cited by 1,323
Ravindran, A. V., Balneaves, L. G., Faulkner, G., Ortiz, A., McIntosh, D., Morehouse, R. L., Ravindran, L., Yatham, L. N., Kennedy, S. H., Lam, R. W., et al. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716660290 · Cited by 337
“It involves keeping patients awake for extended periods, with total SD lasting up to 40 hours and partial SD allowing 3 to 4 hours of sleep per night.(29) Sleep deprivation is typically employed 2 to 4 times over the course of 1 week, with total SD often interspersed with partial SD or normal (recovery) sleep.”
BackgroundSelf-citationNutrition and behavioral health disorders: depression and anxiety
Kris‐Etherton, P. M., Petersen, K. S., Hibbeln, J. R., Hurley, D. L., Kolick, V., Peoples, S., Rodriguez, N. R., & Woodward-Lopez, G. M. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa025 · Cited by 342
“cal trial evidence for benefits of n-3 fatty acids on anxiety disorders in patients who are taking medications for anxiety disorders.(105) However, there is some evidence from small clinical studies showing benefits of n-3 fatty”
BackgroundHerbal Medicine for Anxiety, Depression and Insomnia
Liu, L., Liu, C., Wang, Y., Wang, P., Li, Y., & Li, B. (2015) · Current Neuropharmacology · doi:10.2174/1570159x1304150831122734 · Cited by 243
“Comprehensive descriptions on herbs used to treat depression, anxiety or insomnia have been documented in the recent years [20-24].”
Augsberger, A., Yeung, A., Dougher, M. C., & Hahm, H. C. (2015) · BMC Health Services Research · doi:10.1186/s12913-015-1191-7 · Cited by 233
Supplementation with Omega-3 Fatty Acids in Psychiatric Disorders: A Review of Literature Data
Bozzatello, P., Brignolo, E., Grandi, E. D., & Bellino, S. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5080067 · Cited by 193
“In each case, the evidence supporting the use of omega-3 PUFAs as an anxiolytic is currently insufficient [78].”
The American Psychiatric Association Practice Guidelines for the Psychiatric Evaluation of Adults
Silverman, J. J., Galanter, M. S., Jackson‐Triche, M., Jacobs, D. G., Lomax, J. W., Riba, M., Tong, L., Watkins, K. E., Fochtmann, L. J., Rhoads, R. S., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.1720501 · Cited by 193
Fond, G. B., Hamdani, N., Kapczinski, F. P., Boukouaci, W., Drancourt, N., Dargél, A., Oliveira, J., Guen, E. L., Marlinge, E., Tamouza, R., et al. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12211 · Cited by 175
Health benefits and phenolic compounds of Moringa oleifera leaves: A comprehensive review
Hassan, M., Xu, T., Tian, Y., Zhong, Y., Ali, F. A. Z., Yang, X., & Lu, B. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153771 · Cited by 155
Complementary therapies for clinical depression: an overview of systematic reviews
Haller, H., Anheyer, D., Cramer, H., & Dobos, G. J. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-028527 · Cited by 134
“While some complementary therapies have become a promising adjunct in the standard treatment of depression,(29) 30 others are known for their possible side effects or interactions with standard drugs.(30) Recent clinical practice guidelines, in addition, vary widely in their search strategies and resulting recommendat…”
BackgroundDanielsson, L., Papoulias, I., Petersson, E., Carlsson, J. Y., & Wærn, M. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.06.049 · Cited by 130
Nutrients Turned into Toxins: Microbiota Modulation of Nutrient Properties in Chronic Kidney Disease
Fernández-Prado, R., Esteras, R., Pérez-Gómez, M. V., Gracia-Iguacel, C., González‐Parra, E., Sanz, A. B., Ortíz, A., & Sánchez-Niño, M. D. (2017) · Nutrients · doi:10.3390/nu9050489 · Cited by 109
“However, this use of tryptophan is not supported by scientific evidence [120].”
BackgroundLight therapy in the treatment of patients with bipolar depression: A meta-analytic study
Tseng, P.-T., Chen, Y.-W., Tu, K.-Y., Chung, W., Wang, H.-Y., Wu, C.-K., & Lin, P.-Y. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.03.001 · Cited by 100
The American Psychiatric Association Practice Guidelines for the Psychiatric Evaluation of Adults
(2015) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9780890426760 · Cited by 125
Kaur, G., Invally, M., Sanzagiri, R., & Buttar, H. S. (2015) · Journal of Ayurveda and Integrative Medicine · doi:10.4103/0975-9476.172384 · Cited by 76
“[1] Ravindran and da Silva[2] have”
BackgroundTreatment-resistant panic disorder: clinical significance, concept and management
Chen, M., & Tsai, S. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.02.001 · Cited by 74
de Jonge, P., Wardenaar, K. J., Hoenders, R. H. J., Evans-Lacko, S. E., Kovess–Masféty, V., Aguilar‐Gaxiola, S., Al-Hamzawi, A., Alonso, J., Andrade, L. H., Benjet, C. L., et al. (2017) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796017000774 · Cited by 77
“Standardised translation, back-translation, harmonization and quality control procedures were applied in all of the participating survey sites (Pennell et al. 2008).”
MethodLopresti, A. L., Drummond, P. D., Inarejos-García, A. M., & Pródanov, M. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.02.070 · Cited by 68
Rhee, T. G., Evans, R., McAlpine, D. D., & Johnson, P. J. (2016) · Journal of Primary Care & Community Health · doi:10.1177/2150131916671229 · Cited by 66
Ravindran, A. V., Balneaves, L. G., Faulkner, G., Ortiz, A., McIntosh, D., Morehouse, R. L., Ravindran, L. N., Yatham, L. N., Kennedy, S. H., Lam, R. W. M., et al. (2018) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.16106 · Cited by 67
“It involves keeping patients awake for extended periods, with total SD lasting up to 40 hours and partial SD allowing 3 to 4 hours of sleep per night.(29) Sleep deprivation is typically employed 2 to 4 times over the course of 1 week, with total SD often interspersed with partial SD or normal (recovery) sleep.”
BackgroundSelf-citationMoslemi, F., Alijaniha, F., Naseri, M., Kazemnejad, A., Charkhkar, M., & Heidari, M. R. (2019) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2019.0061 · Cited by 58
“12 13–15 Furthermore, in traditional Persian medicine (TPM), there is a considerable emphasis on using aromatic herbal drugs to relieve emotional disorders, including anxiety.”
Koga, N., Ogura, J., Yoshida, F., Hattori, K., Hori, H., Aizawa, E., Ishida, I., & Kunugi, H. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0536-0 · Cited by 54
Current status of yoga in mental health services
Varambally, S. S., & Gangadhar, B. N. (2016) · International Review of Psychiatry · doi:10.3109/09540261.2016.1159950 · Cited by 54
Döme, P., Tombor, L., Lazáry, J., Gonda, X., & Rihmer, Z. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.12.015 · Cited by 49
Guidelines for the diagnosis and treatment of depressive disorders in China: The second edition
Feng, Y., Xiao, L., Wang, W., Ungvari, G. S., Ng, C. H., Wang, G., & Xiang, Y. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.04.104 · Cited by 49
Prader–Willi syndrome: From genetics to behaviour, with special focus on appetite treatments
Griggs, J. L., Sinnayah, P., & Mathai, M. L. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.003 · Cited by 45
Biofeedback to treat anxiety in young people at clinical high risk for developing psychosis
McAusland, L., & Addington, J. (2018) · Early Intervention in Psychiatry · doi:10.1111/eip.12368 · Cited by 37
Schuch, F. B., da Silveira, L. E., de Zeni, T. C., da Silva, D. P., Wollenhaupt-Aguiar, B., Ferrari, P., Reischak-Oliveira, Á., & Kapczinski, F. P. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.07.072 · Cited by 33
“The Schmidt-Kassow et al. (2012) study used an exercise protocol based on sustained exercise during 30 min.”
MethodCorreale, C., Borgi, M., Collacchi, B., Falamesca, C., Gentile, S., Vigevano, F., Cappelletti, S., & Cirulli, F. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.840107 · Cited by 31
Animal-Assisted Therapy in Pediatric Palliative Care
Gilmer, M. J., Baudino, M. N., Goddard, A., Vickers, D. C., & Akard, T. F. (2016) · Nursing Clinics of North America · doi:10.1016/j.cnur.2016.05.007 · Cited by 33
Psychosocial Effects of a Holistic Ayurvedic Approach to Well-being in Health and Wellness Courses
Patel, S., Klagholz, S., Peterson, C. T., Weiss, L., Chopra, D., & Mills, P. J. (2019) · Global Advances In Health and Medicine · doi:10.1177/2164956119843814 · Cited by 29
“We found that participants in the Seduction of Spirit meditation course experienced a greater reduction in depressed mood scores compared to the other courses, which supports previous data on the beneficial effects of meditation specifically on depression.(34) Participants in the Seduction of Spirit course also spent…”
ResultThe role of n-3 polyunsaturated fatty acids (n-3PUFAs) in affective disorders
Ciappolino, V., Delvecchio, G., Agostoni, C. V., Mazzocchi, A., Altamura, A. C., & Brambilla, P. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.12.034 · Cited by 29
Trkulja, V., & Barić, H. (2020) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-32-9705-0_22 · Cited by 28
Danilovich, M. E., Alberto, M. R., & Tomás, M. S. J. (2021) · Journal of Applied Microbiology · doi:10.1111/jam.15012 · Cited by 29
Malagodi, F., Dommett, E., Findon, J. L., & Gardner, B. (2023) · Mental Health and Physical Activity · doi:10.1016/j.mhpa.2023.100563 · Cited by 29
Eyre, H. A., & Baune, B. T. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.10.026 · Cited by 30
Panic Disorder: A Review of Treatment Options
Ziffra, M. (2021) · Annals of Clinical Psychiatry · doi:10.12788/acp.0014 · Cited by 29
“TABLE 3 lists supplements considered to have possible anti-anxiety effects that have been studied for that purpose.(115-126) While some of these supplements have modest evidence validating their use for other problems (for example, St.”
Insight in psychosis: An independent predictor of outcome or an explanatory model of illness?
Jacob, K. S. (2014) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2014.06.001 · Cited by 26
Kishore, R. K., Abhishekh, H. A., Udupa, K., Thirthalli, J., Lavekar, G. S., Gangadhar, B. N., Raju, T. R., & Sathyaprabha, T. N. (2014) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2014.07.002 · Cited by 28
Jacob, K. (2016) · Indian Journal of Psychological Medicine · doi:10.4103/0253-7176.183078 · Cited by 24
“[15] People with mental illness commonly combine modern medicine with complementary and alternative therapies for relief of symptoms and distress.[41] Patients and their families seem to be comfortable with compartmentalizing their contradictory EMs and seek diverse forms of cure and healing.”
BackgroundPain in Mucopolysaccharidoses: Analysis of the Problem and Possible Treatments
Congedi, S., ORZALESI, M. M., Pede, C. D., & Benini, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103063 · Cited by 23
“Non-pharmacological therapies should be taken into consideration in addition to the pharmacological ones mostly for illness associated emotional, social, and spiritual disturbances and in the case of chronic pain [96].”
BackgroundRavindran, A. V., McKay, M. S., Silva, T. D., Tindall, C., Garfinkel, T., Paric, A., & Ravindran, L. (2021) · The Canadian Journal of Psychiatry · doi:10.1177/0706743720940535 · Cited by 22
“Depressed patients are often seeking these options, partly due to poor access to conventional treatments, but in addition, they often perceive CAMs as safer, accessible, more tolerable, and easily acceptable compared to pharmaceuticals.(15) It has been estimated that 10% to 30% of depressed patients use CAM therapies,…”
BackgroundSelf-citationBanaschewski, T., Belsham, B., Bloch, M. H., Ferrín, M., Johnson, M., Kustow, J., Robinson, S., & Zuddas, A. (2018) · Nutrition and Health · doi:10.1177/0260106018772170 · Cited by 27
“Data from autism (van Elst et al., 2014), anxiety disorders (Ravindran and da Silva, 2013) and obsessive–compulsive disorder studies (Fux et al., 2004) are too sparse from which to draw conclusions.”
BackgroundVoluntary exercise enables stress resistance in females
Tanner, M. K., Fallon, I. P., Baratta, M. V., & Greenwood, B. N. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111923 · Cited by 23
Effect of Osteopathic Manipulative Therapy on Generalized Anxiety Disorder
Dixon, L., Fotinos, K., Sherifi, E., Lokuge, S., Fine, A., Furtado, M., Anand, L., Liberatore, K., & Katzman, M. A. (2020) · Journal of Osteopathic Medicine · doi:10.7556/jaoa.2020.026 · Cited by 20
Oketch‐Rabah, H. A., Roe, A. L., Gurley, B. J., Griffiths, J. C., & Giancaspro, G. I. (2016) · Journal of Nutrition · doi:10.3945/jn.115.227280 · Cited by 19
“, insomnia, mood alteration, and pain control) (18), despite the mixed evidence for its effectiveness for these conditions.”
BackgroundTsai, C.-Y., Yang, H.-C., Islam, M., Hsieh, W.-S., Juan, S.-H., Chen, J.-C., Khan, H. A., & Jian, W.-S. (2017) · International Journal for Quality in Health Care · doi:10.1093/intqhc/mzx123 · Cited by 14
“We found that psychotropic medication prescription has increased in adolescents over the study period, although the percentage of adolescents treated with psychotropic medications was still lower than in the USA (6%), [11], Italy (2.”
BackgroundStreeter, C. C., Gerbarg, P. L., Nielsen, G. H., Brown, R. P., Jensen, J. E., & Silveri, M. M. (2018) · PubMed · doi:10.4172/neuropsychiatry.1000535 · Cited by 19
Gautam, S., Jain, A., Marwale, A., & Gautam, A. (2020) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_776_19 · Cited by 16
Tennis enhances well-being in university students
Yazıcı, A. B., Gul, M. O., Yazıcı, E., & Gül, G. K. (2016) · Mental Illness · doi:10.4081/mi.2016.6510 · Cited by 21
Integrating yoga in mental health services
Gangadhar, B. N., & Varambally, S. S. (2015) · The Indian Journal of Medical Research · doi:10.4103/0971-5916.160685 · Cited by 13
Olatunji, T. L., Siebert, F., Adetunji, A. E., Harvey, B. H., Gericke, J., Hamman, J. H., & van der Kooy, F. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114476 · Cited by 12
Non-pharmacological strategies to decrease anxiety in cardiac catheterization: integrative review
Ferreira, N. D. C., Ramalho, E. D. S., & Lopes, J. D. L. (2015) · Revista Brasileira de Enfermagem · doi:10.1590/0034-7167.2015680614i · Cited by 12
Faisal‐Cury, A., & Rodrigues, D. M. D. O. (2022) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2022.102146 · Cited by 11
Acupuncture for Major Depressive Disorder: A Systematic Review
Sorbero, M. E. S., Reynolds, K. A., Colaiaco, B., Lovejoy, S. L., Farris, C. A., Vaughan, C., Sloan, J., Kandrack, R., Apaydin, E. A., & Herman, P. M. (2015) · Rand health quarterly · doi:10.7249/rhq-05-04-07 · Cited by 11
Schieffler, D. A., & Matta, S. E. (2021) · Military Medicine · doi:10.1093/milmed/usab130 · Cited by 10
Zarghi, S. S., Ghezeljeh, T. N., & Rasouli, M. (2020) · Journal of Client-centered Nursing Care · doi:10.32598/jccnc.6.2.34.2 · Cited by 11
Practice Guidelines for the Psychiatric Evaluation of Adults, Third Edition
(2015) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9780890426760.pe02 · Cited by 13
Yoga-based interventions for the management of psychiatric disorders
Varambally, S. S., & Gangadhar, B. N. (2016) · Cambridge University Press eBooks · doi:10.1017/cbo9781316157565.010 · Cited by 9
Yoga in Psychiatry: An Examination of Concept, Efficacy, and Safety
Reddy, M. S. S., & Vijay, M. S. (2016) · Indian Journal of Psychological Medicine · doi:10.4103/0253-7176.185948 · Cited by 9
“Anxiety and depression There are many studies[4‐6] showing improvement in anxiety and depressive symptoms (level 3 evidence[7]) Editorial”
Gnasso, R., Corrado, B. M., Iommazzo, I., Migliore, F., Magliulo, G., Giardulli, B., & Ruosi, C. (2022) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-022-02402-w · Cited by 8
“in 2018, instead, in their systematic review have summarised the effects of complementary and alternative medicine (CAM) on depression, panic and anxiety disorders [49].”
BackgroundOlatunji, T. L., Siebert, F., Adetunji, A. E., Harvey, B. H., Gericke, J., Hamman, J. H., & van der Kooy, F. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114711 · Cited by 8
On Gelsemium and Complementary and Alternative Medicine (CAM) in Anxiety and Experimental Neurology
Chirumbolo, S. (2014) · Neurology and Therapy · doi:10.1007/s40120-014-0025-6 · Cited by 8
Zhao, F.-Y., Kennedy, G. A., Xu, P., Conduit, R., Wang, Y., Zhang, W., Wang, H., Yue, L.-P., Huang, Y., Wang, Y., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1290580 · Cited by 7
“on termination, however, can be major deterrents to compliance, and affect over 50% of users in the longer-term (20, 22, 23).”
BackgroundPráticas corporais no Centro de Atenção Psicossocial de Álcool e Drogas: a percepção dos usuários
da Silva, P. P. C., dos Santos, A. R. M., dos Santos, P. D. J. C., Rodrigues, E. A. P. C., & de Freitas, C. M. S. M. (2018) · Revista Brasileira de Ciências do Esporte · doi:10.1016/j.rbce.2018.08.004 · Cited by 8
Use of Recorded Poetic Audios to Manage Levels of Anxiety and Sleep Disorders
dos Reis, A. C., Vidal, C. L., Caetano, K. A. D. S., & Dias, H. D. (2019) · Journal of Religion and Health · doi:10.1007/s10943-019-00947-y · Cited by 7
Neurotrophic paths in the treatment of depression
Hayley, S. P., & Anisman, H. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130146 · Cited by 7
Lipids in the Treatment of Mental Disorders
Lange, K. W. (2020) · Wiley eBooks · doi:10.1002/047167849x.bio120 · Cited by 7
Pasten, C. S., & Caneo, C. (2022) · Medwave · doi:10.5867/medwave.2022.01.002146 · Cited by 6
Sebastianski, M., Gates, M., Gates, A., Nuspl, M., Bialy, L. M., Featherstone, R. M., Breault, L. J., Mason-Lai, P., & Hartling, L. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-026847 · Cited by 7
Rådmark, L., Hanson, L. L. M., Montgomery, S., Horwitz, E. B., & Osika, W. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.012 · Cited by 7
Chronobiology and Treatment in Depression
Geoffroy, P. A., & Yeim, S. (2017) · Springer eBooks · doi:10.1007/978-981-10-6577-4_9 · Cited by 5
MATSUURA, Y., Watanabe, Y., Taniguchi, H., Koga, Y., Yasuno, F., & SAKAI, T. (2020) · Clinical Medicine Insights Case Reports · doi:10.1177/1179547620967379 · Cited by 5
Aktaş, Y. Y., & Karabulut, N. (2017) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2017.10.004 · Cited by 4
Adjunctive Docosahexaenoic Acid in Residual Symptoms of Depression and Anxiety
Piperoglou, M., Hopwood, M., & Norman, T. R. (2023) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001767 · Cited by 4
Morbid Anxiety: Identification and Treatment
Goddard, A. W. (2017) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20160046 · Cited by 4
Treatment-Resistant Panic Disorder
Chen, M., & Tsai, S. (2018) · Springer eBooks · doi:10.1007/978-981-10-4358-1_13 · Cited by 5
Thomas, S. R. (2015) · Advances in Integrative Medicine · doi:10.1016/j.aimed.2015.03.001 · Cited by 4
“In a review of complementary antidepressant augmentation agents, Ravindran notes that serotonin syndrome resulting from augmentation of antidepressants with L-tryptophan is ‘‘rare’’ [19].”
BackgroundEyre, H. A. (2014) · Journal of Yoga & Physical Therapy · doi:10.4172/2157-7595.1000165 · Cited by 4
“A number of primary research, meta-analyses and systematic reviews have examined the efficacy of various subtypes of PA in depression [26,34,29-32,48-54].”
BackgroundRådmark, L., Hanson, L. L. M., Horwitz, E. B., & Osika, W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184635 · Cited by 5
Castelli, L., Galasso, L., Borrelli, M., Esposito, F., Caumo, A., Michielon, G., Roveda, E., & Montaruli, A. (2025) · BMC Public Health · doi:10.1186/s12889-025-25951-8 · Cited by 3
“Notably, physical activity has been shown to be as effective as pharmacological or psychological treatments in alleviating symptoms of anxiety, psychological distress, and depression, primarily through activation of the serotonergic and noradrenergic systems [49–52].”
Plantas utilizadas en la medicina popular paraguaya para tratar afecciones relacionadas al estrés
Ebenhoch, R., Saenger, K., Crosa, F., González, Y. P., & de Arrúa, R. D. (2021) · Revista de la Sociedad Científica del Paraguay · doi:10.32480/rscp.2021.26.1.82 · Cited by 3
Palmieri, M. A., Agosti, L. P., Bové, M., Sikora, V., Santoro, M., Tucci, P., Schiavone, S., Trabace, L., & Morgese, M. G. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111362 · Cited by 3
“Research indicates that n-3 PUFA may have antidepressant effects through their ability to modulate neuroinflammation, influence neurotransmitters and improve neuro-plasticity (Ravindran and da Silva, 2013).”
Yoga and Traditional Healing Methods in Mental Health
Varambally, S. S., & Gangadhar, B. N. (2020) · Mental health and illness worldwide · doi:10.1007/978-981-10-2345-3_20 · Cited by 4
John, T. M. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35868-2.00021-9 · Cited by 4
Roberts, K., Dowell, A. C., & Nie, J. (2020) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2020.101114 · Cited by 3
Exploring on the comparative merit of allopathy medicine and yoga therapy for PCOD condition
Devi, C. R., & Rani, N. J. (2022) · International Journal of Health Sciences · doi:10.53730/ijhs.v6ns3.5187 · Cited by 2
Kim, R. W., & Kim, M. (2024) · Journal of Integrative and Complementary Medicine · doi:10.1089/jicm.2023.0577 · Cited by 4
“16 Particularly, aromatherapy is widely utilized as one of the various complementary and alternative therapies for alleviating anxiety.”
Nimri, L., Zohar, L., & Horovitz, O. (2024) · Food and Humanity · doi:10.1016/j.foohum.2024.100407 · Cited by 2
S-Adenosyl-L-Methionine for Major Depressive Disorder
Berardis, D. D., Orsolini, L., Iasevoli, F., Tomasetti, C., Mazza, M., Valchera, A., Fornaro, M., Perna, G., Piersanti, M., Nicola, M. D., et al. (2016) · Springer eBooks · doi:10.1007/978-81-322-2803-5_49 · Cited by 2
Body practices in rehabilitation alcohol and drugs users: a lifestyle setting
da Silva, P. P. C., dos Santos, A. R. M., dos Santos, P. D. J. C., & de Freitas, C. M. S. M. (2017) · Motricidade · doi:10.6063/motricidade.12945 · Cited by 2
Reddan, J. M., Gauci, S., Young, L. M., Kennedy, G., Rowsell, R., Minihane, A. M., Scholey, A. B., & Pipingas, A. (2024) · British Journal Of Nutrition · doi:10.1017/s0007114524002204 · Cited by 1
“Interestingly, one commonly cited reason for the use of complementary medicines, such as dietary supplements, in the general population is to help manage chronic diseases (5) , including mental health issues such as disordered mood (6,7) .”
Jellesma, F. C. (2013) · Cited by 1
Laux, G. (2017) · Springer eBooks · doi:10.1007/978-3-662-49295-6_67 · Cited by 2
Karmakar, D., Sen, S., Banerjee, A., & Ghosh, S. (2024) · Vulnerable Children and Youth Studies · doi:10.1080/17450128.2024.2418496 · Cited by 1
Thulesius, H. O. (2015) · Scandinavian Journal of Primary Health Care · doi:10.3109/02813432.2015.1030175 · Cited by 1
Komplementärmedizin im Krankenhaus: Strategien, Konzepte, Umsetzung
Hoefert, H.-W., & Michalsen, A. (2014) · Medizinisch Wissenschaftliche Verlagsgesellschaft eBooks · doi:10.32745/9783954664573 · Cited by 1
Treatment of Adolescent Mental Disorders: Cross‐Cultural Issues
Yang, X., & Chiu, M. Y.-L. (2020) · The Encyclopedia of Child and Adolescent Development · doi:10.1002/9781119171492.wecad339 · Cited by 1
Rådmark, L., Magnusson, L. H., Horwitz, E. B., & Osika, W. (2017) · MindRxiv (OSF Preprints) · doi:10.31231/osf.io/bma9y · Cited by 1
Schilling, R., Cody, R., Kreppke, J.-N., Faude, O., Beck, J., Brand, S., Donath, L., Hatzinger, M., Imboden, C., Lang, U. E., et al. (2024) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2024.1447821 · Cited by 1
Metadata
- Authors
- Ravindran, A. V., & da Silva, T. L.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- Ravindran, Arun V.
- ORCID
- Ravindran, Arun V.
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 150
- Issue
- 3
- Pages
- 707-719
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W1977854880
- Cited by
- 121
- References
- 201
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 9 · 2020: 12 · 2019: 10 · 2018: 9 · 2017: 14 · 2016: 18 · 2015: 18 · 2014: 7 · 2013: 4
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Keywords
- complementary and alternative medicine, adjunctive therapy, antidepressants, depression, anxiety disorders, bipolar depression, sleep deprivation, physical activity, yoga, phototherapy, omega-3 fatty acids, S-adenosylmethionine, tryptophan, generalized anxiety disorder, panic disorder, safety and tolerability
- MeSH terms
- Complementary Therapies, Anxiety Disorders, Combined Modality Therapy, Female, Humans, Male, Phototherapy, S-Adenosylmethionine, Tryptophan, Yoga, Fatty Acids, Omega-3, Meditation, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
