Alterations of functional connectivity and intrinsic activity within the cingulate cortex of suicidal ideators
Open accessAbstract
The 'default mode network' (DMN), a collection of brain regions including the posterior cingulate cortex (PCC), shows reliable inter-regional functional connectivity at rest. It has been implicated in rumination and other negative affective states, but its role in suicidal ideation is not well understood. We employed seed based functional connectivity methods to analyze resting state fMRI data in 34 suicidal ideators and 40 healthy control participants. Whole-brain connectivity with dorsal PCC or ventral PCC was broadly intact between the two groups, but while the control participants showed greater coupling between the dorsal anterior cingulate cortex (dACC) and dorsal PCC, compared to the dACC and ventral PCC, this difference was reversed in the ideators. Furthermore, ongoing low frequency BOLD signal in these three regions (dorsal, ventral PCC, dACC) was reduced in the ideators. The structural integrity of the cingulum bundle, as measured using diffusion tensor imaging (DTI), also explained variation in the functional connectivity measures but did not abolish the group differences. Together, these findings provide evidence of abnormalities in the DMN underlying the tendency towards suicidal ideation.
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Individuals with a history of suicidal ideation show abnormal resting-state connectivity between prefrontal control regions and subcortical brain regions.
“individuals with a history of suicidal ideation appear to show abnormal resting state connectivity between PFC control regions and subcortical brain regions (Chase et al. 2017, Ordaz et al. 2018)”
From Adolescent Suicide as a Failure of Acute Stress-Response Systems. (2019) · cites this paper as Chase et al. 2017
The Results (Group differences in connectivity; page unavailable) report abnormal resting-state connectivity in suicidal ideators, chiefly between the dorsal anterior cingulate cortex and posterior cingulate cortex. They do not report an ideator–control difference in connectivity between prefrontal control regions and subcortical regions. The Results (Main effects; page unavailable) mention prefrontal and subcortical connectivity across participants, not as an abnormality in ideators. (LLM, conf=0.88)
Experimental — accuracy not yet measuredSuicidal ideation relates to greater rs-fMRI activity in the vmPFC and greater resting functional connectivity between the OFC and amygdala and between the posterior cingulate cortex and middle temporal gyrus.
“Suicidal ideation relates to greater rs-fMRI activity in the vmPFC (88) and greater resting functional connectivity between the OFC and amygdala (89) and between the posterior cingulate cortex and middle temporal gyrus (90), perhaps related to negative self-reflection or rumination (91).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [90]
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References 53 · Cited by 78
Research works printed but not linked: 2
- Jung K-J Kohli N Yeh F-C Keller TA Zhao T 2013 Motion correction in diffusion spectrum imaging using simulated diffusion images at multiple b bands Proceedings of the 21st Annual Meeting of the ISMRM Salt Lake City, Utah 3192
- Jung KJ 2010 Sensitivity of motion estimation to the anisotropic diffusion of white matter in diffusion MRI Proceedings of the 18th Annual Meeting of the ISMRM Stockholm, Sweden 4036
- Authors
- Chase, H. W., Segreti, A. M., Keller, T. A., Cherkassky, V. L., Just, M. A., Pan, L. A., & Brent, D. A.
- Affiliations
- University of Pittsburgh (US)
- Carnegie Mellon University (US)
- Corresponding author
- Chase, Henry W.
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 212
- Pages
- 78-85
- ISSN
- 0165-0327 (ISSN-L)
- PMC
- PMC5358995
- OpenAlex
- W2573819071
- Cited by
- 78
- References
- 53
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 11 · 2020: 11 · 2019: 14 · 2018: 8 · 2017: 2
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Figshare (submittedVersion, cc-by-nc-nd)
- KiltHub Repository
- Funders
- National Institute of Mental Health (R01MH029617)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Keywords
- suicidal ideation, default mode network, posterior cingulate cortex, anterior cingulate cortex, functional connectivity, resting state, rumination, negative affect, cingulum, structural integrity, intrinsic brain activity
- MeSH terms
- Adult, Brain Mapping, Emotions, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Young Adult, Diffusion Tensor Imaging, Suicidal Ideation
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