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Evaluating an e-mental health program (“deprexis”) as adjunctive treatment tool in psychotherapy for depression: Results of a pragmatic randomized controlled trial
Open accessAbstract
Background Depressive disorders place a significant disease burden on individuals as well as on societies. Several web-based interventions for depression have shown to be effective in reducing depressive symptoms. However, it is not known whether web-based interventions, when used as adjunctive treatment tools to regular psychotherapy, have an additional effect compared to regular psychotherapy for depression.Methods Adults (N = 98) with a unipolar affective disorder were recruited in routine outpatient psychotherapy practices in Germany from therapists over the course of their initial sessions and randomized within therapists to one of two active treatment conditions: regular psychotherapy or psychotherapy plus a web-based depression program ("deprexis"). Primary outcome was depressive symptoms measured with the Beck Depression Inventory (BDI-II) at 12 weeks. Secondary outcomes were anxiety symptoms, somatic symptoms and quality of life at 12 weeks and six months follow-up. The study also included an assessment of the working alliance after six and 12 weeks.Results The combination of psychotherapy with the web-based program was more effective than psychotherapy alone at 12 weeks, with medium between-group effect sizes on primary depressive symptoms (Cohen's d = .51) and small to medium between-group effect sizes on secondary outcomes (Cohen's d = .07-.55). Furthermore, we did not observe negative side effects in the blended format, e.g., a lower working alliance than in psychotherapy alone.Limitations The study had a smaller than planned sample size and the dropout rate at follow-up was high.Conclusions This study provides first evidence that the use of a web-based program as an adjunctive tool in regular psychotherapy could be a promising option to consider in future treatment for depression.
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“In this randomized controlled trial, integrated blended therapy was superior over standard psychotherapy (d = 0.51; n = 98).”
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The present and future of blended care: current research and introduction to the B-FIT framework
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Kneubühler, A. M., von Känel, E., Grgić, K., Munkovic, E., Berger, T., & Bielinski, L. L. (2026) · JMIR Mental Health · doi:10.2196/78079 · Cited by 1
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InfluentialDigitale Gesundheitsanwendungen
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Erste Evidenz für eine Online-Schulung zu körperbezogenen repetitiven Verhaltensweisen
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“So far, the efficacy and feasibility of blended therapy compared to a control group has been shown in studies using a range of mental disorders such as depression and anxiety disorders compared to a control group [7,8] as well as compared to face-to-face therapy [9].”
Self-citationInternet-/Online-basierte Psychotherapieverfahren
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Metadata
- Authors
- Berger, T., Krieger, T., Sude, K., Meyer, B., & Maercker, A.
- Affiliations
- University of Bern (CH)
- City, University of London (GB)
- Corresponding author
- Berger, Thomas
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 227
- Pages
- 455-462
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2767843933
- Cited by
- 153
- References
- 46
- Citations by year
- 2026: 15 · 2025: 18 · 2024: 14 · 2023: 19 · 2022: 23 · 2021: 17 · 2020: 19 · 2019: 15 · 2018: 12
- FWCI
- 14.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Affective Disorders (acceptedVersion)
- PubMed (publishedVersion)
- BORIS (University Library Bern) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PP00P1_144824/1)
- European Commission
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- depression, e-mental health, online intervention, Deprexis, adjunctive therapy, psychotherapy, blended treatment, therapeutic relationship, depressive symptoms, anxiety symptoms, somatic symptoms, quality of life, unipolar affective disorder
- MeSH terms
- Adult, Combined Modality Therapy, Major Depressive Disorder, Female, Germany, Humans, Male, Middle Aged, Psychotherapy, Software, Somatoform Disorders, Therapy, Computer-Assisted, Internet
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