Relationship between novel inflammatory biomarker galectin-3 and depression symptom severity in a large community-based sample
Open accessAbstract
Major depressive disorder is associated with pro-inflammatory markers, such as cytokines TNF-alpha, IL-6, IL-1ß, and C-reactive protein. Galectin-3 is a novel emerging biomarker with pro-inflammatory properties. It is a saccharide binding protein distributed throughout many tissues with varying functions and is a predictor of poor outcomes in patients with heart failure and stroke. However, its role as a predictor in depressive symptom severity remains undefined. Data from the community-based Dallas Heart Study (n = 2554) were examined using a multiple linear regression analysis to evaluate the relationship between galectin-3 and depressive symptom severity as assessed with Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR) scores. Additional covariates included age, sex, race/ethnicity, body mass index (BMI), years of education, serum creatinine, history of diabetes, and smoking history. Galectin-3 levels statistically significantly predicted QIDS-SR depressive symptom severity (β = 0.055, p = .015). Female sex, smoking status, and BMI were found to be statistically significant positive predictors of depression severity, while age, years of education, non-Hispanic White race, and Hispanic ethnicity were negative predictors of depressive symptom severity. In this large sample, higher galectin-3 levels were associated with higher levels of depressive symptoms. The findings suggest that galectin-3 may be a new and useful inflammatory biomarker associated with depression.
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Research works printed but not linked: 1
- North C, Yutzy S, 2018 Mood (Affective Disorders), Goodwin and Guze’s Psychiatric Diagnosis 7th Edition. Oxford University Press, USA, pp. 15– 59.
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“Moreover, King and colleagues reported that higher levels of Gal-3 were associated with greater depressive symptoms in a community-based sample of patients with heart failure and stroke (45).”
BackgroundGalectin-3 in Microglia-Mediated Neuroinflammation: Implications for Central Nervous System Diseases
Tian, Y.-K., Ye, D.-W., Ge, M.-M., Chen, N., Zhou, Y.-Q., & Yang, H. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220201094547 · Cited by 31 · see citing works
- Authors
- King, D. R., Salako, D. C., Arthur-Bentil, S. K., Rubin, A. E., Italiya, J. B., Tan, J. S., Macris, D. G., Neely, H. K., Palka, J. M., Grodin, J. L., Davis-Bordovsky, K., Faubion, M., North, C. S., & Brown, E. S.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- North, Carol S.
- Brown, E. Sherwood
- ORCID
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 281
- Pages
- 384-389
- ISSN
- 0165-0327 (ISSN-L)
- PMC
- PMC7856258
- OpenAlex
- W3111025659
- Cited by
- 29
- References
- 56
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 3
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- galectin-3, depression, depression severity, inflammatory markers, inflammation, major depressive disorder, QIDS-SR, Dallas Heart Study, sex differences, smoking, body mass index, race and ethnicity
- MeSH terms
- Depression, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Psychiatric Status Rating Scales, Severity of Illness Index, Biomarkers, Galectin 3
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