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Cited by 112Physical Activity and HealthTreatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Antidepressants or running therapy: Comparing effects on mental and physical health in patients with depression and anxiety disorders

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Verhoeven, Josine E., Han, Laura K.M., Lever-van Milligen, Bianca A., Hu, Mandy X., Révész, Dóra, Hoogendoorn, Adriaan W., Batelaan, Neeltje M., van Schaik, Digna J.F., van Balkom, Anton J.L.M., van Oppen, Patricia, Penninx, Brenda W.J.H.·2023·Journal of Affective Disorders
DOI 10.1016/j.jad.2023.02.064
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Abstract

BACKGROUND: Antidepressant medication and running therapy are both effective treatments for patients with depressive and anxiety disorders. However, they may work through different pathophysiological mechanisms and could differ in their impact on physical health. This study examined effects of antidepressants versus running therapy on both mental and physical health. METHODS: According to a partially randomized patient preference design, 141 patients with depression and/or anxiety disorder were randomized or offered preferred 16-week treatment: antidepressant medication (escitalopram or sertraline) or group-based running therapy ≥2 per week. Baseline (T0) and post-treatment assessment at week 16 (T16) included mental (diagnosis status and symptom severity) and physical health indicators (metabolic and immune indicators, heart rate (variability), weight, lung function, hand grip strength, fitness). RESULTS: Of the 141 participants (mean age 38.2 years; 58.2 % female), 45 participants received antidepressant medication and 96 underwent running therapy. Intention-to-treat analyses showed that remission rates at T16 were comparable (antidepressants: 44.8 %; running: 43.3 %; p = .881). However, the groups differed significantly on various changes in physical health: weight (d = 0.57; p = .001), waist circumference (d = 0.44; p = .011), systolic (d = 0.45; p = .011) and diastolic (d = 0.53; p = .002) blood pressure, heart rate (d = 0.36; p = .033) and heart rate variability (d = 0.48; p = .006). LIMITATIONS: A minority of the participants was willing to be randomized; the running therapy was larger due to greater preference for this intervention. CONCLUSIONS: While the interventions had comparable effects on mental health, running therapy outperformed antidepressants on physical health, due to both larger improvements in the running therapy group as well as larger deterioration in the antidepressant group. TRIAL REGISTRATION: Trialregister.nl Number of identification: NTR3460.

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Crossref · 10.1016/j.jad.2023.02.064

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Metadata

Authors
Verhoeven, J. E., Han, L. K. M., Lever-van Milligen, B. A., Hu, M. X., Révész, D., Hoogendoorn, A. W., Batelaan, N. M., van Schaik, D. J. F., van Balkom, A. J. L. M., van Oppen, P., & Penninx, B. W. J. H.
Affiliations
  • Amsterdam Neuroscience (NL)
  • Tilburg University (NL)
Corresponding author
Verhoeven, Josine E.
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2023-05
Volume
329
Pages
19-29
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/j.jad.2023.02.064
OpenAlex
W4321483614
Cited by
112
References
60
Citations by year
2026: 28 · 2025: 43 · 2024: 32 · 2023: 9
FWCI
19.77
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Affective Disorders (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (submittedVersion, cc-by)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders
  • ZonMw (636310017)
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (91811602)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
antidepressants, running therapy, depression, anxiety disorders, escitalopram, sertraline, physical health, weight, blood pressure, heart rate variability, exercise therapy, patient preferences, remission
MeSH terms
Adult, Antidepressive Agents, Anxiety Disorders, Depression, Female, Humans, Male, Hand Strength, Sertraline

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