Drug–Nutrient Interactions: A Broad View with Implications for Practice
Abstract
The relevance of drug?nutrient interactions in daily practice continues to grow with the widespread use of medication. Interactions can involve a single nutrient, multiple nutrients, food in general, or nutrition status. Mechanistically, drug?nutrient interactions occur because of altered intestinal transport and metabolism, or systemic distribution, metabolism and excretion, as well as additive or antagonistic effects. Optimal patient care includes identifying, evaluating, and managing these interactions. This task can be supported by a systematic approach for categorizing interactions and rating their clinical significance. This review provides such a broad framework using recent examples, as well as some classic drug?nutrient interactions. Pertinent definitions are presented, as is a suggested approach for clinicians. This important and expanding subject will benefit tremendously from further clinician involvement.
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Picking the proper nutritional assessment method depends greatly on the setting, the objective of the study, and the characteristics of the population.
“Given the diversity of nutritional assessment tools, picking the proper method depends greatly on the setting, the objective of the study, and the characteristics of the population [59,60].”
From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [60]
Nutrient-drug interactions represent a clinically relevant interface in which medications may alter nutrient absorption, metabolism, distribution, and excretion, while nutrients may influence drug pharmacokinetics and therapeutic efficacy.
“NDIs represent a clinically relevant interface in which medications may alter nutrient absorption, metabolism, distribution, and excretion, while nutrients may influence drug pharmacokinetics and therapeutic efficacy [60].”
From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [60]
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The Role of Polyphenols in Human Health and Food Systems: A Mini-Review
Cory, H., Passarelli, S., Szeto, J., Tamez, M., & Mattei, J. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00087 · Cited by 1,297 · see citing works
The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review
Zambrano-Villacres, R., Arteaga-Pazmiño, C., Guevara Castillo, W. D., Herrera-Fontana, M. E., Domínguez Brito, L. D., Becerra Granados, L. M., Recoba-Obregón, P. E., Rodríguez-Veintimilla, D., Bressi, V., Andrade-Molina, D., et al. (2026) · Applied Sciences · doi:10.3390/app16020845 · Cited by 5 · see citing works
- Authors
- Boullata, J. I., & Hudson, L. M.
- Affiliations
- Hospital of the University of Pennsylvania (US)
- Corresponding author
- Boullata, Joseph I.
- ORCID
- Boullata, Joseph I.
- Venue
- Journal of the Academy of Nutrition and Dietetics
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 112
- Issue
- 4
- Pages
- 506-517
- ISSN
- 2212-2672 (ISSN-L)
- OpenAlex
- W2027526799
- Cited by
- 138
- References
- 3
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 8 · 2023: 7 · 2022: 36 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 11 · 2015: 6 · 2014: 14 · 2013: 8 · 2012: 1
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Academy of Nutrition and Dietetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Health Professions › Health Information Management › Dietetics, Nutrition, and Education
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- drug-nutrient interactions, food-drug interactions, nutritional status, intestinal nutrient transport, drug metabolism, drug excretion, interaction classification
- MeSH terms
- Biological Availability, Dietetics, Energy Metabolism, Humans, Intestinal Absorption, Nutritional Status, Pharmacokinetics, Risk Factors, Food-Drug Interactions, Dietary Supplements
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