The Role of Polyphenols in Human Health and Food Systems: A Mini-Review
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This narrative mini- review summarizes current knowledge of the role of polyphenols in health outcomes-and non-communicable diseases specifically-and discusses the implications of this evidence for public health, and for future directions for public health practice, policy, and research. The publications cited originate mainly from animal models and feeding experiments, as well as human cohort and case-control studies. Hypothesized protective effects of polyphenols in acute and chronic diseases, including obesity, neurodegenerative diseases, type 2 diabetes, and cardiovascular diseases, are evaluated. Potential harmful effects of some polyphenols are also considered, counterbalanced with the limited evidence of harm in the research literature. Recent international governmental regulations are discussed, as the safety and health claims of only a few specific polyphenolic compounds have been officially sanctioned. The implications of food processing on the bioavailability of polyphenols are also assessed, in addition to the health claims and marketing of polyphenols as a functional food. Finally, this mini-review asserts the need for increased regulation and guidelines for polyphenol consumption and supplementation in order to ensure consumers remain safe and informed about polyphenols.
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Some studies highlight that high doses of pure compounds increase the risk of stroke and premature death.
“and others highlighting the increased risk of stroke and premature death [235]”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [235]
The in vivo safety of high doses of pure compounds (over 100 times higher than the natural occurrence in some cases) is unlikely to be feasibly extrapolated from in vitro mechanistic research.
“Furthermore, the in vivo safety of high doses of pure compounds (over 100 times higher than the natural occurrence in some cases) is unlikely to be feasibly extrapolated from in vitro mechanistic research, with several studies reporting the increased risk of hepatotoxicity [234], and others highlighting the increased risk of stroke and premature death [235], and even carcinogenesis [236].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [235]
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Cites
Plant Polyphenols as Dietary Antioxidants in Human Health and Disease
Pandey, K. B., & Rizvi, S. I. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.5.9498 · Cited by 4,727 · see citing works
Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties
Dai, J., & Mumper, R. J. (2010) · Molecules · doi:10.3390/molecules15107313 · Cited by 4,541 · see citing works
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601 · see citing works
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275 · see citing works
Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects
Zhang, H., & Tsao, R. (2016) · Current Opinion in Food Science · doi:10.1016/j.cofs.2016.02.002 · Cited by 1,519 · see citing works
Iron bioavailability and dietary reference values
Hurrell, R., & Egli, I. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.28674f · Cited by 1,359 · see citing works
Interactions of polyphenols with carbohydrates, lipids and proteins
Jakobek, L. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.12.013 · Cited by 1,236 · see citing works
Hydrogen peroxide scavenging, antioxidant and anti-radical activity of some phenolic acids
Sroka, Z., & Cisowski, W. (2003) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00329-0 · Cited by 946 · see citing works
Novel insights of dietary polyphenols and obesity
Wang, S. F., Moustaïd‐Moussa, N., Chen, L., Mo, H., Shastri, A. A., Su, R., Bapat, P., Kwun, I., & Shen, C. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.09.001 · Cited by 903 · see citing works
The therapeutic potential of resveratrol: a review of clinical trials
Berman, A. Y., Motechin, R. A., Wiesenfeld, M. Y., & Holz, M. K. (2017) · npj Precision Oncology · doi:10.1038/s41698-017-0038-6 · Cited by 895 · see citing works
Rothwell, J. A., Pérez‐Jiménez, J., Neveu, V., Medina‐Remón, A., M'hiri, N., Garcia-Lobato, P., Manach, C., Knox, C., Eisner, R., Wishart, D. S., et al. (2013) · Database · doi:10.1093/database/bat070 · Cited by 884 · see citing works
Falowo, A. B., Fayemi, P. O., & Muchenje, V. (2014) · Food Research International · doi:10.1016/j.foodres.2014.06.022 · Cited by 860 · see citing works
Pérez‐Jiménez, J., Neveu, V., Vos, F., & Scalbert, A. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.221 · Cited by 798 · see citing works
Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties
Marín, L., Miguélez, E. M., Villar, C. J., & Lombó, F. (2015) · BioMed Research International · doi:10.1155/2015/905215 · Cited by 778 · see citing works
Natural Polyphenols for Prevention and Treatment of Cancer
Zhou, Y., Zheng, J., Li, Y., Xu, D.-P., Li, S., Chen, Y., & Li, H. (2016) · Nutrients · doi:10.3390/nu8080515 · Cited by 749 · see citing works
Basic biochemical mechanisms behind the health benefits of polyphenols
Fraga, C. G., Galleano, M., Verstraeten, S. V., & Oteiza, P. I. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.006 · Cited by 748 · see citing works
Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota
Lee, H. C., Jenner, A. M., Low, C. S., & Lee, Y. K. (2006) · Research in Microbiology · doi:10.1016/j.resmic.2006.07.004 · Cited by 697 · see citing works
Interactions of gut microbiota with functional food components and nutraceuticals
Laparra, J. M., & Sanz, Y. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2009.11.001 · Cited by 684 · see citing works
The Case for Anthocyanin Consumption to Promote Human Health: A Review
Pojer, E., Mattivi, F., Johnson, D., & Stockley, C. S. (2013) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12024 · Cited by 636 · see citing works
Wootton-Beard, P. C., Moran, A., & Ryan, L. (2010) · Food Research International · doi:10.1016/j.foodres.2010.10.033 · Cited by 631 · see citing works
The gut microbiota: a key factor in the therapeutic effects of (poly)phenols
Espín, J. C., González-Sarrías, A., & Tomás-Barberán, F. A. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.04.033 · Cited by 603 · see citing works
Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice
Ejaz, A., Wu, D., Kwan, P., & Meydani, M. (2009) · Journal of Nutrition · doi:10.3945/jn.108.100966 · Cited by 585 · see citing works
Carbonell-Capella, J. M., Buniowska, M., Barba, F., Esteve, M., & Frígola, A. (2014) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12049 · Cited by 580 · see citing works
Papuc, C. P., GORAN, G. V., Predescu, N. C., Nicorescu, V., & Ștefan, G. (2017) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12298 · Cited by 576 · see citing works
Miglio, C., Chiavaro, E., Visconti, A., Fogliano, V., & Pellegrini, N. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf072304b · Cited by 573 · see citing works
Porras, D., Nistal, E., Martínez‐Flórez, S., Pisonero‐Vaquero, S., Olcoz, J. L., Jover, R., González‐Gallego, J., García‐Mediavilla, M. V., & Sánchez‐Campos, S. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.037 · Cited by 528 · see citing works
Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area.
Orgogozo, J. M., Dartigues, J. F., Lafont, S., Letenneur, L., Commenges, D., Salamon, R., Renaud, S., & Breteler, M. M. B. (1997) · PubMed · Cited by 525 · see citing works
Control of Biogenic Amines in Food—Existing and Emerging Approaches
Naila, A., Flint, S., Fletcher, G. C., Bremer, P. J., & Meerdink, G. (2010) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01774.x · Cited by 508 · see citing works
EFSA Panel on Dietetic Products, N. A. A. (. (2011) · EFSA Journal · doi:10.2903/j.efsa.2011.2033 · Cited by 491 · see citing works
Polyphenols: Benefits to the Cardiovascular System in Health and in Aging
Khurana, S., Venkataraman, K., Hollingsworth, A., Piché, M., & Tai, T. C. (2013) · Nutrients · doi:10.3390/nu5103779 · Cited by 438 · see citing works
Zhang, B., Deng, Z., Ramdath, D. D., et al. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.09.144 · Cited by 429 · see citing works
Antiobesity effects of green tea catechins: a mechanistic review
Rains, T. M., Agarwal, S., & Maki, K. C. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.06.006 · Cited by 425 · see citing works
Polyphenol Oxidases in Crops: Biochemical, Physiological and Genetic Aspects
Taranto, F., Pasqualone, A., Mangini, G., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020377 · Cited by 424 · see citing works
Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network
Navarro, V. J., Barnhart, H., Bonkovsky, H. L., Davern, T., Fontana, R. J., Grant, L., Reddy, R. K., Seeff, L. B., Serrano, J., Sherker, A. H., et al. (2014) · Hepatology · doi:10.1002/hep.27317 · Cited by 418 · see citing works
Hepatotoxicity from green tea: a review of the literature and two unpublished cases
Mazzanti, G., Menniti‐Ippolito, F., Moro, P. A., Cassetti, F., Raschetti, R., Santuccio, C., & Mastrangelo, S. (2009) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-008-0610-7 · Cited by 412 · see citing works
Dietary Polyphenols and Obesity
Meydani, M., & Hasan, S. T. (2010) · Nutrients · doi:10.3390/nu2070737 · Cited by 389 · see citing works
Dietary Polyphenols and Type 2 Diabetes: Current Insights and Future Perspectives
Xiao, J., & Högger, P. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140706130807 · Cited by 361 · see citing works
Dong, J.-Y., & Qin, L. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1270-8 · Cited by 355 · see citing works
Curry Consumption and Cognitive Function in the Elderly
Ng, T. P., Chiam, P., Lee, T. M., Chua, H.-C., Lim, L. E. C., & Kua, E. H. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj267 · Cited by 353 · see citing works
The effects of green tea on weight loss and weight maintenance: a meta-analysis
Hursel, R., Viechtbauer, W., & Westerterp‐Plantenga, M. S. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.135 · Cited by 323 · see citing works
Six-Week Consumption of a Wild Blueberry Powder Drink Increases Bifidobacteria in the Human Gut
Vendrame, S., Guglielmetti, S., Riso, P., Arioli, S., Klimis‐Zacas, D. J., & Porrini, M. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2028686 · Cited by 313 · see citing works
Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy?
Weiskirchen, S., & Weiskirchen, R. (2016) · Advances in Nutrition · doi:10.3945/an.115.011627 · Cited by 310 · see citing works
Shao, W., Yu, Z., Chiang, Y., Yang, Y., Chai, T., Foltz, W. D., Lu, H., Fantus, I. G., & Jin, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0028784 · Cited by 307 · see citing works
Dietary polyphenols: Structures, bioavailability and protective effects against atherosclerosis
Santhakumar, A. B., Battino, M. A., & Álvarez-Suárez, J. M. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.01.022 · Cited by 300 · see citing works
Amount and type of alcohol and risk of dementia
Truelsen, T. C., Thudium, D., & Grønbæk, M. (2002) · Neurology · doi:10.1212/01.wnl.0000031421.50369.e7 · Cited by 283 · see citing works
Aquilano, K., Baldelli, S., Rotilio, G., & Ciriolo, M. R. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9697-6 · Cited by 267 · see citing works
Probiotics modulate gut microbiota and improve insulin sensitivity in DIO mice
Bagarolli, R. A., Tobar, N., Oliveira, A. G., Araújo, T. G., Carvalho, B. M., Rocha, G. Z., Vecina, J. F., Calisto, K., Guadagnini, D., Prada, P. O., et al. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.08.006 · Cited by 266 · see citing works
Polyphenols as dietary supplements: A double-edged sword
Martin, K. R. (2009) · Nutrition and Dietary Supplements · doi:10.2147/nds.s6422 · Cited by 265 · see citing works
Martín‐Peláez, S., Covas, M. I., Fitó, M., Kušar, A., & Pravst, I. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200421 · Cited by 259 · see citing works
Papandreou, M. A., Dimakopoulou, A. G., Linardaki, Z. I., Cordopatis, P. A., Klimis‐Zacas, D. J., Margarity, M., & Lamari, F. N. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.11.013 · Cited by 244 · see citing works
Evaluation of the antioxidant potential of grape seed and bearberry extracts in raw and cooked pork
Carpenter, R., O’Grady, M. N., O’Callaghan, Y. C., O’Brien, N. M., & Kerry, J. P. (2007) · Meat Science · doi:10.1016/j.meatsci.2007.01.021 · Cited by 243 · see citing works
Dietary polyphenols in the prevention and treatment of allergic diseases
Singh, A., Holvöet, S., & Mercenier, A. (2011) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2011.03773.x · Cited by 242 · see citing works
Antioxidant supplements and mortality
Bjelakovic, G., Nikolova, D., & Gluud, C. (2013) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000009 · Cited by 234 · see citing works
Benefits from Dietary Polyphenols for Brain Aging and Alzheimer’s Disease
Rossi, L. C., Mazzitelli, S., Arciello, M., Capo, C. R., & Rotilio, G. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9696-7 · Cited by 216 · see citing works
Bozkurt, H. (2006) · Meat Science · doi:10.1016/j.meatsci.2006.01.005 · Cited by 212 · see citing works
de Souza, E. L., de Albuquerque, T. M. R., dos Santos, A. S., Massa, N. M. L., & Alves, J. L. D. B. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1425285 · Cited by 200 · see citing works
Effect of phenolic compounds on the growth of selected probiotic and pathogenic bacteria
Pacheco‐Ordaz, R., Wall‐Medrano, A., Goñi, M. G., Montfort, G. R.-C., Ayala-Zavala, J. F., & González-Aguilar, G. A. (2017) · Letters in Applied Microbiology · doi:10.1111/lam.12814 · Cited by 193 · see citing works
Sahebkar, A. (2013) · Nutrition Reviews · doi:10.1111/nure.12081 · Cited by 192 · see citing works
Antioxidants: Friends or foe in prevention or treatment of cancer: The debate of the century
Saeidnia, S., & Abdollahi, M. R. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.05.004 · Cited by 190 · see citing works
González‐Sarrías, A., Espı́n, J. C., & Tomás-Barberán, F. A. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.07.010 · Cited by 190 · see citing works
Hepatotoxicity of green tea: an update
Mazzanti, G., Di Sotto, A., & Vitalone, A. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1521-x · Cited by 189 · see citing works
Dietary reference intake (DRI) value for dietary polyphenols: are we heading in the right direction?
Williamson, G., & Holst, B. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508006867 · Cited by 185 · see citing works
Brain Iron Metabolism Dysfunction in Parkinson’s Disease
Jiang, H. F., Wang, J., Rogers, J. T., & Xie, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9879-1 · Cited by 183 · see citing works
Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics
García-Cortés, M., Robles-Díaz, M., Ortega-Alonso, A., Medina-Caliz, I., & Andrade, R. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040537 · Cited by 179 · see citing works
Wang, Y., Li, F., Zhuang, H., Chen, X., Li, L., Qiao, W., & Zhang, J. (2014) · LWT · doi:10.1016/j.lwt.2014.09.022 · Cited by 175 · see citing works
Noguchi-Shinohara, M., Yuki, S., Dohmoto, C., Ikeda, Y., Samuraki, M., Iwasa, K., Yokogawa, M., Asai, K., Komai, K., Nakamura, H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096013 · Cited by 174 · see citing works
Li, T., Li, J., Hu, W., et al. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.04.115 · Cited by 173 · see citing works
Position of the Academy of Nutrition and Dietetics: Functional Foods
Crowe, K. M., & Francis, C. (2013) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2013.06.002 · Cited by 170 · see citing works
A Discussion of Polyphenols in Beer Physical and Flavour Stability
Aron, P. M., & Shellhammer, T. H. (2010) · Journal of the Institute of Brewing · doi:10.1002/j.2050-0416.2010.tb00788.x · Cited by 167 · see citing works
Barrett, A. H., Farhadi, N. F., & Smith, T. J. (2017) · LWT · doi:10.1016/j.lwt.2017.09.002 · Cited by 161 · see citing works
Hursel, R., Viechtbauer, W., Dulloo, A. G., Tremblay, A., Tappy, L., Rumpler, W. V., & Westerterp‐Plantenga, M. S. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00862.x · Cited by 160 · see citing works
Atheroprotective effects of (poly)phenols: a focus on cell cholesterol metabolism
Zanotti, I., Dall’Asta, M., Mena, P. R., Mele, L., Bruni, R., Ray, S., & Rio, D. D. (2014) · Food & Function · doi:10.1039/c4fo00670d · Cited by 158 · see citing works
Fenwick, G. R., Hanley, A. B., & Whitaker, J. R. (1985) · C R C Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398509527419 · Cited by 155 · see citing works
Li, J., He, X., Li, M., et al. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.12.040 · Cited by 150 · see citing works
Dietary polyphenols regulate endothelial function and prevent cardiovascular disease
Yamagata, K., Tagami, M., & Yamori, Y. (2014) · Nutrition · doi:10.1016/j.nut.2014.04.011 · Cited by 148 · see citing works
Szkudelska, K., Nogowski, L., & Szkudelski, T. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.11.001 · Cited by 138 · see citing works
Drug–Nutrient Interactions: A Broad View with Implications for Practice
Boullata, J. I., & Hudson, L. M. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jada.2011.09.002 · Cited by 138 · see citing works
Antiobesity Effects of Anthocyanins in Preclinical and Clinical Studies
Azzini, E., Giacometti, J., & Russo, G. L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2740364 · Cited by 131 · see citing works
(ANS), E. P. O. F. A. A. N. S. A. T. F. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4246 · Cited by 130 · see citing works
Bao, H. N. D., Ushio, H., & Ohshima, T. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8017063 · Cited by 109 · see citing works
Guo, H., Chen, Y.-L., Liao, L.-Z., & Wu, W.-K. (2013) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-013-6442-4 · Cited by 106 · see citing works
Fujiki, H., Sueoka, E., Watanabe, T., et al. (2015) · Journal of Cancer Prevention · doi:10.15430/jcp.2015.20.1.1 · Cited by 100 · see citing works
Zhang, Q. Q., Jiang, M., Rui, X., Li, W., Chen, X. H., & Dong, M. S. (2017) · Food Control · doi:10.1016/j.foodcont.2017.02.054 · Cited by 94 · see citing works
Dietary patterns, insulin sensitivity and inflammation in older adults
Anderson, A. L., Harris, T. B., Tylavsky, F. A., Perry, S. E., Houston, D. K., Lee, J. S., Kanaya, A. M., Sahyoun, N. R., & Study, F. T. H. A. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.162 · Cited by 93 · see citing works
Guo, R., Li, W., Liu, B., Li, S., Zhang, B., & Xu, Y. (2014) · Medical science monitor basic research/Medical science monitor. Basic research · doi:10.12659/msmbr.890858 · Cited by 92 · see citing works
Natural Polyphenols and Cardioprotection
Lecour, S., & Lamont, K. T. (2011) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/13895575111091191 · Cited by 85 · see citing works
Selby-Pham, S. N. B., Miller, R. B., Howell, K. S., Dunshea, F. R., & Bennett, L. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-01888-w · Cited by 84 · see citing works
Zhong, X.-S., Ge, J., Chen, S.-W., et al. (2016) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2016.09.036 · Cited by 77 · see citing works
Kim, J., Kim, S., Huh, K., Kim, Y., Joung, H., & Park, M.-J. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04127.x · Cited by 69 · see citing works
Influence of polyphenols on allergic immune reactions: mechanisms of action
Magrone, T., & Jirillo, E. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000109 · Cited by 67 · see citing works
Törrönen, R., McDougall, G. J., Dobson, G., Stewart, D., Hellström, J., Mattila, P. H., Pihlava, J., Koskela, A. K. J., & Karjalainen, R. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2012.05.001 · Cited by 66 · see citing works
Auclair, S., Chironi, G. N., Milenković, D., Hollman, P. C. H., Renard, C. M. G. C., Megnien, J. L., Gariépy, J., Paul, J. L., Simon, A. C., & Scalbert, A. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.135 · Cited by 66 · see citing works
Ogle, W. O., Speisman, R. B., & Ormerod, B. K. (2012) · Gerontology · doi:10.1159/000342208 · Cited by 62 · see citing works
In Vitro Research on Dietary Polyphenols and Health: A Call of Caution and a Guide on How To Proceed
Ávila‐Gálvez, M. Á., González‐Sarrías, A., & Espı́n, J. C. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03377 · Cited by 61 · see citing works
EFSA Panel on Dietetic Products, N. A. A. (. (2014) · EFSA Journal · doi:10.2903/j.efsa.2014.3654 · Cited by 59 · see citing works
Molecular Interactions between (−)-Epigallocatechin Gallate Analogs and Pancreatic Lipase
Wang, S., Sun, Z., Dong, S., Liu, Y., & Liu, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111143 · Cited by 57 · see citing works
Jaiswal, A. K., & Abu‐Ghannam, N. (2013) · Food Research International · doi:10.1016/j.foodres.2013.04.007 · Cited by 57 · see citing works
Effects of tea polyphenol on quality and shelf life of pork sausages
Wenjiao, F., Yunchuan, C., Jun-xiu, S., et al. (2013) · Journal of Food Science and Technology · doi:10.1007/s13197-013-1076-x · Cited by 52 · see citing works
Yang, X., Belosay, A., Hartman, J. A., et al. (2015) · Clinical & Experimental Metastasis · doi:10.1007/s10585-015-9709-2 · Cited by 48 · see citing works
Schneider, M., Esposito, D., Lila, M. A., & Foegeding, E. A. (2016) · Food & Function · doi:10.1039/c5fo01499a · Cited by 48 · see citing works
Dietary Phytochemicals Promote Health by Enhancing Antioxidant Defence in a Pig Model
Selby-Pham, S. N. B., Cottrell, J. J., Dunshea, F. R., Ng, K., Bennett, L. E., & Howell, K. S. (2017) · Nutrients · doi:10.3390/nu9070758 · Cited by 33 · see citing works
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Jackson, C. C., & Paliyath, G. (2011) · Wiley eBooks · doi:10.1002/9780470960844.ch2 · Cited by 28 · see citing works
Soybean isoflavones attenuate the expression of genes related to endometrial cancer risk
Carbonel, A. A. F., Calió, M. L., dos Santos, M. A., et al. (2014) · Climacteric · doi:10.3109/13697137.2014.964671 · Cited by 27 · see citing works
Habas, K., Brinkworth, M. H., & Anderson, D. (2017) · Toxicology · doi:10.1016/j.tox.2017.03.013 · Cited by 27 · see citing works
Novel Technologies for the Production of Functional Foods
Ofori, J. A., & Hsieh, Y. P. (2013) · doi:10.1002/9781118451915.ch8 · Cited by 25 · see citing works
Nguyen, R. H. N., Umbach, D. M., Parad, R. B., Stroehla, B. C., Rogan, W. J., & Estroff, J. A. (2010) · Pediatric Radiology · doi:10.1007/s00247-010-1895-0 · Cited by 25 · see citing works
Whitsett, M. P., Marzio, D. H., & Rossi, S. (2014) · ACG Case Reports Journal · doi:10.14309/crj.2014.59 · Cited by 18 · see citing works
Isolation and Characterization of Novel Microsatellite Markers for Yellow Perch (Perca flavescens)
Zhan, A., Wang, Y., Brown, B. L., et al. (2008) · International Journal of Molecular Sciences · doi:10.3390/ijms10010018 · Cited by 17 · see citing works
Selby-Pham, S. N. B., Howell, K. S., Dunshea, F. R., Ludbey, J., Lutz, A., & Bennett, L. E. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.10.102 · Cited by 15 · see citing works
Polyphenol antioxidants in commercial chocolate bars: Is the label accurate?
Vinson, J. A., & Motisi, M. J. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.12.022 · Cited by 11 · see citing works
Polyphenols in the diet: friend or foe?
Hooper, B., & Frazier, R. A. (2012) · Nutrition Bulletin · doi:10.1111/j.1467-3010.2012.02001.x · Cited by 10 · see citing works
Wine Polyphenols in the Management of Cardiovascular Risk Factors
Arranz, S., Chiva‐Blanch, G., Lamuela-Raventós, R. M., & Estruch, R. (2013) · Polyphenols in Human Health and Disease · doi:10.1016/b978-0-12-398456-2.00077-3 · Cited by 7 · see citing works
Selby-Pham, S. N. B., Osborne, S. A., Howell, K. S., et al. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.10.016 · Cited by 7 · see citing works
Miyatake, N., Sakano, N., & Numata, T. (2012) · Open Journal of Epidemiology · doi:10.4236/ojepi.2012.22007 · Cited by 4 · see citing works
Zhang, H., Liu, Q., Lin, J., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.07.097 · Cited by 4 · see citing works
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Panzella, L., Moccia, F., Nasti, R., Marzorati, S., Verotta, L., & Napolitano, A. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00060 · Cited by 448 · see citing works
Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases
Mirabelli, M., Chiefari, E., Arcidiacono, B., Corigliano, D. M., Brunetti, F. S., Maggisano, V., Russo, D., Foti, D. P., & Brunetti, A. (2020) · Nutrients · doi:10.3390/nu12041066 · Cited by 272 · see citing works
“Furthermore, the in vivo safety of high doses of pure compounds (over 100 times higher than the natural occurrence in some cases) is unlikely to be feasibly extrapolated from in vitro mechanistic research, with several studies reporting the increased risk of hepatotoxicity [234], and others highlighting the increased…”
BackgroundGaforio, J. J., Visioli, F., Alarcón-de-la-Lastra, C., Castañer, O., Delgado-Rodríguez, M., Fitó, M., Hernández, A. F., Huertas, J. R., Martínez-González, M. A., Menendez, J. A., et al. (2019) · Nutrients · doi:10.3390/nu11092039 · Cited by 187 · see citing works
Rahman, M. H., Bajgai, J., Fadriquela, A., Sharma, S., Trinh, T. T., Akter, R., Jeong, Y. J., Goh, S. H., Kim, C.-S., & Lee, K.-J. (2021) · Molecules · doi:10.3390/molecules26175327 · Cited by 182 · see citing works
Murador, D. C., de Souza Mesquita, L. M., Vannuchi, N., Braga, A. R. C., & de Rosso, V. V. (2019) · Current Opinion in Food Science · doi:10.1016/j.cofs.2019.03.002 · Cited by 158 · see citing works
Del Bo', C., Bernardi, S., Cherubini, A., Porrini, M., Gargari, G., Hidalgo-Liberona, N., González-Domínguez, R., Zamora-Ros, R., Peron, G., Marino, M., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.12.014 · Cited by 133 · see citing works
Skin protection from solar ultraviolet radiation using natural compounds: a review
Verma, A., Zanoletti, A., Kareem, K. Y., Adelodun, B., Kumar, P., Ajibade, F. O., Silva, L. F. O., Phillips, A. J., Kartheeswaran, T., Bontempi, E., et al. (2024) · Environmental Chemistry Letters · doi:10.1007/s10311-023-01649-4 · Cited by 102 · see citing works
A High Polyphenol Diet Improves Psychological Well-Being: The Polyphenol Intervention Trial (PPhIT)
Kontogianni, M. D., Vijayakumar, A., Rooney, C., Noad, R. L., Appleton, K. M., McCarthy, D., Donnelly, M., Young, I. S., McKinley, M. C., McKeown, P. P., et al. (2020) · Nutrients · doi:10.3390/nu12082445 · Cited by 83 · see citing works
Angeloni, S., Freschi, M., Marrazzo, P., Hrelia, S., Beghelli, D., Juan-García, A., Juan, C., Caprioli, G., Sagratini, G., & Angeloni, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6620913 · Cited by 50 · see citing works
Azaroual, L., Liazid, A., Mansouri, F. E., Brigui, J., Ruíz-Rodriguez, A., Barbero, G. F., & Palma, M. (2021) · Agronomy · doi:10.3390/agronomy11081527 · Cited by 33 · see citing works
Tomaselli, S., La Vitola, P., Pagano, K., Brandi, E., Santamaria, G., Galante, D., D’Arrigo, C., Moni, L., Lambruschini, C., Banfi, L., et al. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00241 · Cited by 29 · see citing works
- Authors
- Cory, H., Passarelli, S., Szeto, J., Tamez, M., & Mattei, J.
- Affiliations
- Harvard University (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Mattei, Josiemer
- Venue
- Frontiers in Nutrition
- Publisher
- Frontiers Media SA
- Published
- 2018-09-21
- Volume
- 5
- Pages
- 87-87
- ISSN
- 2296-861X (ISSN-L)
- PMC
- PMC6160559
- OpenAlex
- W2890239906
- Cited by
- 1,297
- References
- 115
- Citations by year
- 2026: 122 · 2025: 118 · 2024: 164 · 2023: 215 · 2022: 240 · 2021: 230 · 2020: 162 · 2019: 43 · 2018: 2
- FWCI
- 11.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Nutrition (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Robert Wood Johnson Foundation
- Consejo Nacional de Ciencia y Tecnología
- National Heart, Lung, and Blood Institute (HL120951)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Keywords
- polyphenols, non-communicable diseases, obesity, neurodegenerative diseases, type 2 diabetes, cardiovascular disease, health claims regulation, functional foods, food processing, bioavailability, dietary supplementation, public health policy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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