Depressive Symptoms and Circadian Activity Rhythm Disturbances in Community-Dwelling Older Women
Open accessAbstract
Objectives Aging is associated with changes in circadian rhythms. Current evidence supports a role for circadian rhythms in the pathophysiology of depression. However, little is known about the relationship between depressive symptoms and circadian activity rhythms in older adults. We examined this association in community-dwelling older women.Methods We performed a cross-sectional analysis of 3,020 women (mean age: 83.55 ± 3.79 years) enrolled in the Study of Osteoporotic Fractures. Depressive symptoms were assessed with the Geriatric Depression Scale categorizing participants as "normal" (0-2; referent group, N = 1,961), "some depressive symptoms" (3-5, N = 704), or "depressed" (≥6, N = 355). Circadian activity rhythm variables were measured using wrist actigraphy.Results In age-adjusted and Study of Osteoporotic Fractures site-adjusted models, greater levels of depressive symptoms were associated with decreased amplitude (height; df = 3,014, t = -11.31, p for linear trend <0.001), pseudo F-statistic (robustness; df = 3,014, t = -8.07, p for linear trend <0.001), and mesor (mean modeled activity; df = 3014, t = -10.36, p for linear trend <0.001) of circadian activity rhythms. Greater levels of depressive symptoms were also associated with increased odds of being in the lowest quartile for amplitude (df = 1, χ(2) = 9240, p for linear trend <0.001), pseudo F-statistic (df = 1, χ(2) = 49.73, p for linear trend <0.001), and mesor (df = 1, χ(2) = 81.12, p for linear trend <0.001). These associations remained significant in multivariate models. Post-hoc analyses comparing mean amplitude, mesor, and pseudo F-statistic values pair-wise between depression-level groups revealed significant differences between women with "some depressive symptoms" and the "normal" group.Conclusion These data suggest a graded association between greater levels of depressive symptoms and more desynchronization of circadian activity rhythms in community-dwelling older women. This association was observed even for women endorsing subthreshold levels of depressive symptoms.
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Among cosinor-based metrics, lower pseudo-F statistic values and later acrophase, both based on steps and heart rate, were associated with more severe symptoms, but these correlations became nonsignificant after FDR correction and in multiple regression analysis.
“our data indicated lower pseudo-F statistic values and later acrophase, both based on steps and heart rate, in participants with more severe symptoms, which is consistent with existing evidence [22,23,25,26,29,30], yet these correlations became nonsignificant after the FDR correction and in multiple regression analysis.”
From Digital Biomarkers for Depression Screening With Wearable Devices: Cross-sectional Study With Machine Learning Modeling (2021) · cites this paper as [25]
Our data did not show a relationship with cosinor-based metrics estimating the level of activity, including mesor and rhythm amplitude, or with nonparametric measures, including M10, L5, and RA.
“our data did not show a relationship with cosinor-based metrics estimating the level of activity, including mesor and rhythm amplitude [24,25], or with nonparametric measures, including M10, L5, and RA.”
From Digital Biomarkers for Depression Screening With Wearable Devices: Cross-sectional Study With Machine Learning Modeling (2021) · cites this paper as [25]
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References 55 · Cited by 49
- Authors
- Maglione, J. E., Ancoli-Israel, S., Peters, K. W., Paudel, M. L., Yaffe, K., Ensrud, K. E., Tranah, G. J., & Stone, K. L.
- Affiliations
- University of California San Diego (US)
- California Pacific Medical Center (US)
- University of Minnesota (US)
- University of California, San Francisco (US)
- Corresponding author
- Stone, Katie L.
- Venue
- The American Journal of Geriatric Psychiatry
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 22
- Issue
- 4
- Pages
- 349-361
- ISSN
- 1064-7481 (ISSN-L)
- PMC
- PMC4109690
- OpenAlex
- W2064906203
- Cited by
- 49
- References
- 55
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 1
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (AG08415)
- National Institutes of Health (R01 AG027576-22, AG05407, AG05394, AR35583, AR35584, 2 R01 AG027574-22A1, AR35582, AG026720, R25MH7450)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- depressive symptoms, circadian activity rhythm, older women, aging, actigraphy, circadian rhythm desynchronization, amplitude, mesor, community-dwelling older adults, geriatric depression
- MeSH terms
- Aged, Aged, 80 and over, Aging, Circadian Rhythm, Cross-Sectional Studies, Depression, Female, Humans, Risk Factors, Multivariate Analysis, Linear Models, Chronobiology Disorders, Actigraphy
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