The prevalence of severe asthma and low asthma control among Danish adults

von Bülow, Anna; Kriegbaum, Margit; Backer, Vibeke; Porsbjerg, Celeste

doi:10.1016/j.jaip.2014.05.005

Cited by 154Asthma and respiratory diseasesOccupational exposure and asthmaChronic Obstructive Pulmonary Disease (COPD) Research

The prevalence of severe asthma and low asthma control among Danish adults

von Bülow, Anna, Kriegbaum, Margit, Backer, Vibeke, Porsbjerg, Celeste·2014·The Journal of Allergy and Clinical Immunology In Practice

DOI 10.1016/j.jaip.2014.05.005

Open this paper in CoChat — free account

Abstract

Background The prevalence of severe asthma is unknown. However, international expert statements estimate that severe asthma represents 5% to 10 % of the entire asthma population.Objective Based on register data from a nationwide population, we wanted to investigate the prevalence of severe asthma, the extent of asthma control, and contact with specialist care.Methods A descriptive cross-sectional register study was performed. By using a nationwide prescription database, we identified current patients with asthma (age, 18-44 years) in 2010. Severity was classified as severe versus mild-moderate asthma according to the level of antiasthma treatment. We investigated prescription drug use, hospitalizations, emergency department visits, and outpatient clinic visits according to severity.Results Among a nationwide population, we identified 61,583 current patients with asthma. Based on the level of antiasthma treatment, 8.1% of identified patients was classified as having severe asthma. Low asthma control (dispensed prescriptions of prednisolone, emergency department visits, hospitalization, or excessive short-acting β₂-agonist use) was more frequent in subjects with severe asthma (36.4% vs 25.2%, P < .0001); 63.8% with severe asthma and low asthma control were not managed by specialist care. Patients with severe asthma with specialist contact more frequently had impaired asthma control compared with subjects not treated by a specialist (44.4% vs 33.1%, P < .0001).Conclusion Based on the level of treatment, 8.1% of a nationwide population of current patients with asthma was classified as having severe asthma. Low asthma control was more frequent among subjects with severe asthma, and only a minority had access to specialist care. There is room for optimizing asthma management, particularly among patients with severe disease.

Integrity signals

Registry

Crossref · 10.1016/j.jaip.2014.05.005

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Surveys in Denmark described a higher proportion of approximately 8% of severe asthmatics.
“Surveys in Denmark described a higher proportion of ~8% of severe asthmatics (37)”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [37]

GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION
PAUWELS, R. A. (1996) · Arerugī/Arerugi · doi:10.15036/arerugi.45.792 · Cited by 9,997 · see citing works
Expert Panel Report 2: Guidelines for the Diagnosis and Management of Asthma
Program, P., & theDiagnosis, T. E. P. O. (1997) · Cited by 4,082 · see citing works
Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma–Summary Report 2007
(2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.09.029 · Cited by 2,181 · see citing works
British Guideline on the Management of Asthma
British Thoracic Society Scottish Intercollegiate Guidelines Network (2008) · Thorax · doi:10.1136/thx.2008.097741 · Cited by 2,018 · see citing works
An Official American Thoracic Society/European Respiratory Society Statement: Asthma Control and Exacerbations
Reddel, H. K., Taylor, D. R., Bateman, E. D., Boulet, L., Boushey, H. A., Busse, W. W., Casale, T. B., Chanez, P., Enright, P., Gibson, P. G., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200801-060st · Cited by 1,918 · see citing works
Clinical management of asthma in 1999: the Asthma Insights and Reality in Europe (AIRE) study
Rabe, K. F., Vermeire, P., Soriano, J. B., & Maier, W. (2000) · European Respiratory Journal · doi:10.1183/09031936.00.16580200 · Cited by 1,024 · see citing works
Proceedings of the ATS Workshop on Refractory Asthma
(2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.6.ats9-00 · Cited by 905 · see citing works
Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma
Bousquet, J., Mantzouranis, E., Cruz, A. A., Aït-Khaled, N., Baena-Cagnani, C. E., Bleecker, E. R., Brightling, C. E., Burney, P., Bush, A., Busse, W. W., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.07.019 · Cited by 741 · see citing works
The Danish prescription registries.
Gaist, D., Sørensen, H. T., & Hallas, J. (1997) · PubMed · Cited by 570 · see citing works
A new perspective on concepts of asthma severity and control
Taylor, D. R., Bateman, E. D., Boulet, L., Boushey, H. A., Busse, W. W., Casale, T. B., Chanez, P., Enright, P., Gibson, P. G., de Jongste, J. C., et al. (2008) · European Respiratory Journal · doi:10.1183/09031936.00155307 · Cited by 471 · see citing works
The Prevalence of Nonadherence in Difficult Asthma
Gamble, J., Stevenson, M., McCLEAN, E., & Heaney, L. G. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200902-0166oc · Cited by 423 · see citing works
Asthma in older adults
Gibson, P. G., McDonald, V. M., & Marks, G. B. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61087-2 · Cited by 395 · see citing works
Difficult/therapy‐resistant asthmaThe need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies
Ers Task Force on Difficult/therapy-Resistant Asthma, & Bel, E. H. (1999) · European Respiratory Journal · doi:10.1034/j.1399-3003.1999.13e43.x · Cited by 351 · see citing works
Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI)
Bel, E. H., Sousa, A. R., Fleming, L., Bush, A., Chung, K. F., Versnel, J., Wagener, A. H., Wagers, S. S., Sterk, P. J., & Compton, C. (2010) · Thorax · doi:10.1136/thx.2010.153643 · Cited by 342 · see citing works
Costs of asthma are correlated with severity: a 1-yr prospective study
Godard, P., Chanez, P., Siraudin, L., Nicoloyannis, N., & Duru, G. (2001) · European Respiratory Journal · doi:10.1183/09031936.02.00232001 · Cited by 328 · see citing works
Inhaled corticosteroids: Impact on asthma morbidity and mortality
Suissa, S., & Ernst, P. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.115653 · Cited by 305 · see citing works
Effect of asthma exacerbations on health care costs among asthmatic patients with moderate and severe persistent asthma
Ivanova, J. I., Bergman, R., Birnbaum, H. G., Colice, G., Silverman, R. A., & McLaurin, K. K. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.01.039 · Cited by 302 · see citing works
Severe asthma in adults: What are the important questions?
Chanez, P., Wenzel, S. E., Anderson, G. P., Antó, J. M., Bel, E. H., Boulet, L., Brightling, C. E., Busse, W. W., Castro, M., Dahlén, B., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.11.702 · Cited by 275 · see citing works
Asthma control in Europe: A real-world evaluation based on an international population-based study
Cazzoletti, L., Marcon, A., Janson, C., Corsico, A. G., Jarvis, D., Pin, I., Accordini, S., Almar, E., Bugiani, M., Carolei, A., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.09.019 · Cited by 274 · see citing works
Difficult asthma
Barnes, P. J., & Woolcock, A. J. (1998) · European Respiratory Journal · doi:10.1183/09031936.98.12051209 · Cited by 244 · see citing works
The relationship between clinical outcomes and medication adherence in difficult-to-control asthma: Table 1
Murphy, A. C., Proeschal, A., Brightling, C. E., Wardlaw, A. J., Pavord, I. D., Bradding, P. H., & Green, R. H. (2012) · Thorax · doi:10.1136/thoraxjnl-2011-201096 · Cited by 239 · see citing works
Asthma Control in Canada Remains Suboptimal: The Reality of Asthma Control (TRAC) Study
FitzGerald, J. M., Boulet, L., McIvor, A., Zimmerman, S., & Chapman, K. R. (2006) · Canadian Respiratory Journal · doi:10.1155/2006/753083 · Cited by 236 · see citing works
Severe asthma: Lessons from the Severe Asthma Research Program
Wenzel, S. E., & Busse, W. W. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.10.025 · Cited by 234 · see citing works
Prognostic factors of asthma severity: A 9-year international prospective cohort study
de Marco, R., Marcon, A., Jarvis, D., Accordini, S., Almar, E., Bugiani, M., Carolei, A., Cazzoletti, L., Corsico, A. G., Gíslason, D., et al. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.03.019 · Cited by 208 · see citing works
Short-acting β-agonist use and its ability to predict future asthma-related outcomes
Stanford, R. H., Shah, M. B., D’Souza, A. O., Dhamane, A. D., & Schatz, M. X. (2012) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2012.08.014 · Cited by 182 · see citing works
Unawareness and undertreatment of asthma and allergic rhinitis in a general population
Nolte, H., Nepper-Christensen, S., & Backer, V. (2005) · Respiratory Medicine · doi:10.1016/j.rmed.2005.05.012 · Cited by 176 · see citing works
Inhaled corticosteroids and decline of lung function in community residents with asthma
Lange, P. (2006) · Thorax · doi:10.1136/thx.2004.037978 · Cited by 126 · see citing works
Does non-responder bias have a significant effect on the results in a postal questionnaire study?
Kotaniemi, J., Hassi, J., Kataja, M., Jönsson, E., Laitinen, L. A., Sovijärvi, A. R. A., & Lundbäck, B. (2001) · European Journal of Epidemiology · doi:10.1023/a:1015615130459 · Cited by 113 · see citing works
Quality‐of‐life and asthma‐severity in general population asthmatics: results of the ECRHS II study
Siroux, V., Boudier, A., Antó, J. M., Cazzoletti, L., Accordini, S., Alonso, J., Cerveri, I., Corsico, A. G., Gulsvik, A., Jarvis, D., et al. (2008) · Allergy · doi:10.1111/j.1398-9995.2008.01638.x · Cited by 103 · see citing works
Validation of a β-agonist long-term asthma control scale derived from computerized pharmacy data
Schatz, M. X., Zeiger, R. S., Vollmer, W. M., Mosen, D. M., Apter, A. J., Stibolt, T. B., Leong, A., Johnson, M. S., Mendoza, G., & Cook, E. F. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.01.053 · Cited by 101 · see citing works
Nonresponse bias in EC Respiratory Health Survey in Italy
de Marco, R., Verlato, G., Zanolin, E., Bugiani, M., & Drane, J. W. (1994) · European Respiratory Journal · doi:10.1183/09031936.94.07122139 · Cited by 99 · see citing works
Quality of Care and Outcomes of Adults With Asthma Treated by Specialists and Generalists in Managed Care
Wu, A. W., Young, Y., Skinner, E. A., Diette, G. B., Huber, M. T., Peres, A., & Steinwachs, D. M. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.21.2554 · Cited by 98 · see citing works
Development and validation of database indexes of asthma severity and control
Firoozi, F., Lemière, C., Beauchesne, M.-F., Forget, A., & Blais, L. (2007) · Thorax · doi:10.1136/thx.2006.061572 · Cited by 86 · see citing works
Organization and financing of the Danish health care system
Christiansen, T. (2002) · Health Policy · doi:10.1016/s0168-8510(01)00201-9 · Cited by 82 · see citing works
Identification of asthmatic children using prescription data and diagnosis
Moth, G., Vedsted, P., & Schiøtz, P. O. (2007) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-007-0286-4 · Cited by 75 · see citing works
Use of anti-asthmatic medications as a proxy for prevalence of asthma in children and adolescents in Norway:a nationwide prescription database analysis
Furu, K., Skurtveit, S. O., Langhammer, A., & Nafstad, P. H. J. (2007) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-007-0301-9 · Cited by 71 · see citing works
Identifying general practice patients diagnosed with asthma and their exacerbation episodes from prescribing data
Pont, L., van der Werf, G. T., Denig, P., & Haaijer‐Ruskamp, F. M. (2001) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-001-0395-4 · Cited by 56 · see citing works
Pricing and reimbursement of drugs in Denmark
Pedersen, K. M. (2003) · The European Journal of Health Economics · doi:10.1007/s10198-003-0165-6 · Cited by 56 · see citing works
Risk of perinatal mortality associated with inhaled corticosteroid use for the treatment of asthma during pregnancy
Breton, M.-C., Beauchesne, M.-F., Lemière, C., Rey, É., Forget, A., & Blais, L. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.08.018 · Cited by 46 · see citing works
The register-based system of demographic and social statistics in Denmark – an overview
Thygesen, L. C. (1995) · Statistical Journal of the United Nations Economic Commission for Europe · doi:10.3233/sju-1995-12106 · Cited by 43 · see citing works
Control of Asthma Under Specialist Care
Gaga, M., Papageorgiou, N., Ζervas, Ε., Gioulekas, D., & Konstantopoulos, S. (2005) · CHEST Journal · doi:10.1378/chest.128.1.78 · Cited by 37 · see citing works
Unsatisfactory asthma control: astonishing evidence from general practitioners and respiratory medicine specialists.
Braido, F., Baiardini, I., Stagi, E., Piroddi, M. G., Balestracci, S., & Canonica, G. W. (2010) · PubMed · Cited by 36 · see citing works
Quality of care in patients with asthma and rhinitis treated by respiratory specialists and primary care physicians: a 3-year randomized and prospective follow-up study
Backer, V., Nepper-Christensen, S., & Nolte, H. (2006) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)60940-4 · Cited by 34 · see citing works
The Effect of Generalist and Specialist Care on Quality of Life in Asthma Patients with and without Allergic Rhinitis
Harmsen, L., Nolte, H., & Backer, V. (2010) · International Archives of Allergy and Immunology · doi:10.1159/000283041 · Cited by 20 · see citing works
Impact of socioeconomic status on the use of inhaled corticosteroids in young adult asthmatics
Davidsen, J. R., Søndergaard, J., Hallas, J., Siersted, H. C., Knudsen, T. B., Lykkegaard, J., & Andersen, M. T. (2010) · Respiratory Medicine · doi:10.1016/j.rmed.2010.11.009 · Cited by 20 · see citing works
Controlled and uncontrolled allergic asthma in routine respiratory specialist care – a clinical–epidemiological study in Germany
Kardos, P., Wïttchen, H., Mühlig, S., Ritz, T., Buhl, R., Rabe, K. F., Klotsche, J., Riedel, O., & for the sap-NEEDS study group (2011) · Current Medical Research and Opinion · doi:10.1185/03007995.2011.606805 · Cited by 17 · see citing works
The level of control of mild asthma in general practice: an observational community-based study
Caminati, M., Bettoncelli, G., Magnoni, M. S., Rizzi, A., Testi, R., Passalacqua, G., de Marco, R., Caramori, G., & Senna, G. (2013) · Journal of Asthma · doi:10.3109/02770903.2013.843098 · Cited by 16 · see citing works
Research in the Danish health service system: completeness and validity of prescription data, illustrated by analysis of utilization of oral anticoagulants
Sørensen, H. T., Steffensen, F. H., Ejlersen, E., Dahlerup, J. F., & Kristensen, K. (1995) · International Journal of Risk & Safety in Medicine · doi:10.3233/jrs-1995-7104 · Cited by 15 · see citing works
Management of asthma in adults: Do the patients get what they need—and want?
Backer, V., Ulrik, C. S., Harving, H., Lange, P., Søes‐Petersen, U., & Plaschke, P. P. (2007) · Allergy and Asthma Proceedings · doi:10.2500/aap.2007.28.3001 · Cited by 11 · see citing works
Asthma consultations with specialists: What do the pediatricians seek?
Poowuttikul, P., Kamat, D., Thomas, R., & Pansare, M. V. (2011) · Allergy and Asthma Proceedings · doi:10.2500/aap.2011.32.3445 · Cited by 9 · see citing works

Flagged first, then by citations

Sorted by citations

Epidemiology of Asthma in Children and Adults
Dharmage, S. C., Perret, J. L., & Custovic, A. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00246 · Cited by 1,200 · see citing works
Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature
Volmer, T., Effenberger, T., Trautner, C., & Buhl, R. (2018) · European Respiratory Journal · doi:10.1183/13993003.00703-2018 · Cited by 322 · see citing works
Co‐morbidities in severe asthma: <scp>C</scp> linical impact and management
Porsbjerg, C., & Menzies‐Gow, A. (2017) · Respirology · doi:10.1111/resp.13026 · Cited by 233 · see citing works
Utilization and Costs of Severe Uncontrolled Asthma in a Managed-Care Setting
Zeiger, R. S., Schatz, M. N., Dalal, A. A., Qian, L., Chen, W., Ngor, E. W., Suruki, R., & Kawatkar, A. A. (2015) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2015.08.003 · Cited by 164 · see citing works
Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era
Jackson, D. J., Busby, J., Pfeffer, P., Menzies-Gow, A. N., Brown, T., Gore, R. B., Doherty, M., Mansur, A. H., Message, S. D., Niven, R. M., et al. (2020) · Thorax · doi:10.1136/thoraxjnl-2020-215168 · Cited by 161 · see citing works
Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis
Thyssen, J. P., Toft, P. B., Halling, A., Gislason, G., Skov, L., & Egeberg, A. (2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2017.03.003 · Cited by 152 · see citing works
Shadow cost of oral corticosteroids-related adverse events: A pharmacoeconomic evaluation applied to real-life data from the Severe Asthma Network in Italy (SANI) registry
Canonica, G. W., Colombo, G. L., Bruno, G. M., Matteo, S. D., Martinotti, C., Blasi, F., Bucca, C. B., Crimi, N., Paggiaro, P., Pelaia, G., et al. (2019) · World Allergy Organization Journal · doi:10.1016/j.waojou.2018.12.001 · Cited by 120 · see citing works
Asthma biomarkers in the age of biologics
Kim, H. L., Ellis, A. K., Fischer, D., Noseworthy, M., Olivenstein, R., Chapman, K. R., & Lee, J. (2017) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-017-0219-4 · Cited by 110 · see citing works
Severe Asthma in a General Population Study: Prevalence and Clinical Characteristics
Rönnebjerg, L., Axelsson, M., Kankaanranta, H., Bäckman, H., Rådinger, M., Lundbäck, B., & Ekerljung, L. (2021) · Journal of Asthma and Allergy · doi:10.2147/jaa.s327659 · Cited by 110 · see citing works
Systematic literature review of the clinical, humanistic, and economic burden associated with asthma uncontrolled by GINA Steps 4 or 5 treatment
Chen, S. H., Golam, S. M., Myers, J. A., Bly, C. A., Smolen, H. J., & Xu, X. P. (2018) · Current Medical Research and Opinion · doi:10.1080/03007995.2018.1505352 · Cited by 109 · see citing works
Prevalence, disease burden, and treatment reality of patients with severe, uncontrolled asthma in Japan
Nagase, H., Adachi, M., Matsunaga, K., Yoshida, A., 大古場知子, Hayashi, N., Emoto, K., & Tohda, Y. (2019) · Allergology International · doi:10.1016/j.alit.2019.06.003 · Cited by 108 · see citing works
Prevalence and management of severe asthma in primary care: an observational cohort study in Sweden (PACEHR)
Larsson, K., Ställberg, B., Lisspers, K., Telg, G., Johansson, G., Thuresson, M., & Janson, C. (2018) · Respiratory Research · doi:10.1186/s12931-018-0719-x · Cited by 100 · see citing works
“1% were reported to have severe asthma [11].”
BackgroundMethodInfluential
Severe asthma—A population study perspective
Bäckman, H., Jansson, S., Stridsman, C., Eriksson, B., Hedman, L., Eklund, B., Sandström, T., Lindberg, A., Lundbäck, B., & Rönmark, E. (2019) · Clinical & Experimental Allergy · doi:10.1111/cea.13378 · Cited by 99 · see citing works
Oral corticosteroid use, morbidity and mortality in asthma: A nationwide prospective cohort study in Sweden
Ekström, M. P., Nwaru, B. I., Hasvold, P., Wiklund, F., Telg, G., & Janson, C. (2019) · Allergy · doi:10.1111/all.13874 · Cited by 97 · see citing works
Associations of symptoms of anxiety and depression with health-status, asthma control, dyspnoea, dysfunction breathing and obesity in people with severe asthma
Stubbs, M. A., Clark, V. L., Gibson, P. G., Yorke, J., & McDonald, V. M. (2022) · Respiratory Research · doi:10.1186/s12931-022-02266-5 · Cited by 81 · see citing works
Importance of Early COPD in Young Adults for Development of Clinical COPD. Findings from the Copenhagen General Population Study
Çolak, Y., Afzal, S., Nordestgaard, B. G., Lange, P., & Vestbo, J. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202003-0532oc · Cited by 77 · see citing works
Potential Severe Asthma Hidden in UK Primary Care
Ryan, D. P., Heatley, H., Heaney, L. G., Jackson, D. J., Pfeffer, P., Busby, J., Menzies-Gow, A. N., Jones, R. C. M., Tran, T. N., Al-Ahmad, M. S., et al. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.11.053 · Cited by 74 · see citing works
Low-dose oral corticosteroids in asthma associates with increased morbidity and mortality
Skov, I. R., Madsen, H., Henriksen, D. P., Andersen, J. H., Pottegård, A., & Davidsen, J. R. (2022) · European Respiratory Journal · doi:10.1183/13993003.03054-2021 · Cited by 70 · see citing works
Higher mortality of adults with asthma: A 15‐year follow‐up of a population‐based cohort
Lemmetyinen, R., Karjalainen, J., But, A., Renkonen, R., Pekkanen, J., Toppila-Salmi, S. K., & Haukka, J. K. (2018) · Allergy · doi:10.1111/all.13431 · Cited by 70 · see citing works
The Burden of Severe Asthma in France: A Case-Control Study Using a Medical Claims Database
BOURDIN, A. A., Fabry-Vendrand, C., Ostinelli, J., Ait-Yahia, M., Darnal, E., Bouée, S., Laurendeau, C., Bureau, I., Gourmelen, J., & CHOUAID, C. (2019) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2018.12.029 · Cited by 62 · see citing works
Severe Occupational Asthma: Insights From a Multicenter European Cohort
Vandenplas, O., Godet, J., Hurdubaea, L., Rifflart, C., Suojalehto, H., Walusiak‐Skorupa, J., Muñoz, X., Sastre, J., Klusáčková, P., Moore, V. C., et al. (2019) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2019.03.017 · Cited by 62 · see citing works
Development of the International Severe Asthma Registry (ISAR): A Modified Delphi Study
Bulathsinhala, L., Eleangovan, N., Heaney, L. G., Menzies-Gow, A. N., Gibson, P. G., Peters, M. J., Hew, M. J., van Boven, J. F. M., Lehtimäki, L. A., Ganse, E. H. V., et al. (2018) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2018.08.016 · Cited by 59 · see citing works
The real world effect of omalizumab add on therapy for patients with moderate to severe allergic asthma: The ASTERIX Observational study
Bhutani, M., Yang, W. H.-C., Hébert, J., de Takacsy, F., & Stril, J.-L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183869 · Cited by 58 · see citing works
Efficacy, adverse events, and inter-drug comparison of mepolizumab and reslizumab anti-IL-5 treatments of severe asthma – a systematic review and meta-analysis
Henriksen, D. P., Bødtger, U. C. S., Sidenius, K., Maltbæk, N., Pedersen, L., Madsen, H., Andersson, E. A., Norgaard, O., Klokker, L., & Chawes, B. (2018) · European Clinical Respiratory Journal · doi:10.1080/20018525.2018.1536097 · Cited by 57 · see citing works
Lost in the transition from pediatric to adult healthcare? Experiences of young adults with severe asthma
Ödling, M., Jonsson, M., Janson, C., Melén, E., Bergström, A., & Kull, I. (2019) · Journal of Asthma · doi:10.1080/02770903.2019.1640726 · Cited by 57 · see citing works
Defining asthma and assessing asthma outcomes using electronic health record data: a systematic scoping review
Sallakh, M. A. A., Vasileiou, E., Rodgers, S., Lyons, R. A., Sheikh, A., & Davies, G. A. (2017) · European Respiratory Journal · doi:10.1183/13993003.00204-2017 · Cited by 56 · see citing works
Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults
Porsbjerg, C. M., Ulrik, C. S., Skjold, T., Backer, V., Lærum, B. N., Lehman, S., Janson, C., Sandström, T., Bjermer, L. H., Dahlén, B., et al. (2018) · European Clinical Respiratory Journal · doi:10.1080/20018525.2018.1440868 · Cited by 54 · see citing works
Efficacy of azithromycin in severe asthma from the AMAZES randomised trial
Gibson, P. G., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S. J., James, A. L., Jenkins, C. R., Peters, M. J., Marks, G. B., Baraket, M., et al. (2019) · ERJ Open Research · doi:10.1183/23120541.00056-2019 · Cited by 54 · see citing works
International Severe Asthma Registry
Canonica, G. W., Alacqua, M., Altraja, A., Backer, V., Bel, E. H., Bjermer, L. H., Björnsdóttir, U. S., BOURDIN, A. A., Brusselle, G., Christoff, G., et al. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.10.051 · Cited by 53 · see citing works
Efficacy of omalizumab in children, adolescents, and adults with severe allergic asthma: a systematic review, meta-analysis, and call for new trials using current guidelines for assessment of severe asthma
Henriksen, D. P., Bødtger, U. C. S., Sidenius, K., Maltbæk, N., Pedersen, L., Madsen, H., Andersson, E. A., Nørgaard, O., Madsen, L. K., & Chawes, B. (2020) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-020-00442-0 · Cited by 53 · see citing works
Usage Patterns of Short-Acting β2-Agonists and Inhaled Corticosteroids in Asthma: A Targeted Literature Review
Amin, S., Soliman, M., McIvor, A., Cave, A., & Cabrera, C. S. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.03.013 · Cited by 49 · see citing works
Socioeconomic biases in asthma control and specialist referral of possible severe asthma
Håkansson, K. E. J., Backer, V., & Ulrik, C. S. (2021) · European Respiratory Journal · doi:10.1183/13993003.00741-2021 · Cited by 45 · see citing works
Insomnia symptoms and asthma control—Interrelations and importance of comorbidities
Sundbom, F., Malinovschi, A., Lindberg, E., Almqvist, C., & Janson, C. (2019) · Clinical & Experimental Allergy · doi:10.1111/cea.13517 · Cited by 45 · see citing works
Pregnancy complications, treatment characteristics and birth outcomes in women with atopic dermatitis in Denmark
Hamann, C. R., Egeberg, A., Wollenberg, A., Gislason, G., Skov, L., & Thyssen, J. P. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15256 · Cited by 43 · see citing works
Severe asthma is related to high societal costs and decreased health related quality of life
Jansson, S., Bäckman, H., Andersson, M., Telg, G., Lindberg, A., Stridsman, C., Lundbäck, B., & Rönmark, E. (2020) · Respiratory Medicine · doi:10.1016/j.rmed.2019.105860 · Cited by 43 · see citing works
Use of High-Dose Inhaled Corticosteroids and Risk of Corticosteroid-Related Adverse Events in Asthma Findings From the NORDSTAR Cohort
von Bülow, A., Hansen, S., Sandin, P., Cooper, A., Ernstsson, O., Geale, K., Lehtimäki, L. A., Ulrik, C. S., Aarli, B. B., Ilmarinen, P., et al. (2025) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2025.01.023 · Cited by 42 · see citing works
Management of severe asthma: targeting the airways, comorbidities and risk factors
Gibson, P. G., & McDonald, V. M. (2017) · Internal Medicine Journal · doi:10.1111/imj.13441 · Cited by 41 · see citing works
Clinical and economic burden of severe asthma: A French cohort study
Nordon, C., Grimaldi‐Bensouda, L., Pribil, C., Nachbaur, G., Amzal, B., Thabut, G., Marthan, R., Aubier, M., Aubier, M., Crestani, B., et al. (2018) · Respiratory Medicine · doi:10.1016/j.rmed.2018.10.002 · Cited by 41 · see citing works
Living well with severe asthma
Stubbs, M. A., Clark, V. L., & McDonald, V. M. (2019) · Breathe · doi:10.1183/20734735.0165-2019 · Cited by 41 · see citing works
Prevalence and management of severe asthma in the Nordic countries: findings from the NORDSTAR cohort
Hansen, S., von Bülow, A., Sandin, P., Ernstsson, O., Janson, C., Lehtimäki, L. A., Kankaanranta, H., Ulrik, C. S., Aarli, B. B., Wahl, H. F., et al. (2023) · ERJ Open Research · doi:10.1183/23120541.00687-2022 · Cited by 40 · see citing works
Health care resource utilization and cost for asthma patients regularly treated with oral corticosteroids – a Swedish observational cohort study (PACEHR)
Janson, C., Lisspers, K., Ställberg, B., Johansson, G. S., Telg, G., Thuresson, M., Christensen, H. N., & Larsson, K. (2018) · Respiratory Research · doi:10.1186/s12931-018-0855-3 · Cited by 40 · see citing works
High prevalence of severe asthma in a large random population study
Mincheva, R., Ekerljung, L., Bossios, A., Lundbäck, B., & Lötvall, J. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.07.047 · Cited by 37 · see citing works
Efficacy and safety of mepolizumab in Japanese patients with severe eosinophilic asthma
Shimoda, T., Odajima, H., Okamasa, A., Kawase, M., Komatsubara, M., Mayer, B., Yancey, S. W., & Ortega, H. G. (2017) · Allergology International · doi:10.1016/j.alit.2016.11.006 · Cited by 36 · see citing works
Strategies to reduce corticosteroid-related adverse events in asthma
Heffler, E. M., Bagnasco, D., & Canonica, G. W. (2018) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000493 · Cited by 36 · see citing works
The role of antifungals in the management of patients with severe asthma
Rapeport, G., Ito, K., & Denning, D. W. (2020) · Clinical and Translational Allergy · doi:10.1186/s13601-020-00353-8 · Cited by 34 · see citing works
Severe asthma in Japan
Nagase, H. (2019) · Allergology International · doi:10.1016/j.alit.2019.02.004 · Cited by 33 · see citing works
The new era of add-on asthma treatments: where do we stand?
Calhoun, W. J., & Chupp, G. L. (2022) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-022-00676-0 · Cited by 33 · see citing works
Asthma and fixed airflow obstruction: Long‐term trajectories suggest distinct endotypes
Smith, B. M., Zhao, N., Olivenstein, R., Lemière, C., Hamid, Q. A., & Martin, J. G. (2020) · Clinical & Experimental Allergy · doi:10.1111/cea.13714 · Cited by 31 · see citing works
Beyond direct costs: individual and societal financial burden of asthma in young adults in a Danish nationwide study
Håkansson, K. E. J., Løkke, A., Ibsen, R., Hilberg, O., Backer, V., & Ulrik, C. S. (2023) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2022-001437 · Cited by 30 · see citing works
Association of Obesity and Severe Asthma in Adults
Olejnik, A. E., & Kuźnar-Kamińska, B. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13123474 · Cited by 29 · see citing works
Evaluation and Management of Difficult-to-Treat and Severe Asthma: An Expert Opinion From the Korean Academy of Asthma, Allergy and Clinical Immunology, the Working Group on Severe Asthma
Kim, B., Park, S., Ban, G., Kim, M., Lee, J., An, J. Y., Shim, J., Lee, Y., Won, H., Lee, H. Y., et al. (2020) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2020.12.6.910 · Cited by 29 · see citing works
Complete response to anti-interleukin-5 biologics in a real-life setting: results from the nationwide Danish Severe Asthma Register
Soendergaard, M. B., Hansen, S., Bjerrum, A., Hilberg, O., Johansson, S. L., Håkansson, K. E. J., Ingebrigtsen, T. S., Johnsen, C. R., Rasmussen, L. M., von Bülow, A., et al. (2022) · ERJ Open Research · doi:10.1183/23120541.00238-2022 · Cited by 29 · see citing works
Asthma Prevalence and Phenotyping in the General Population: The LEAD (Lung, hEart, sociAl, boDy) Study
Schiffers, C., Wouters, E. F. �., Breyer‐Kohansal, R., Buhl, R., Pohl, W., Irvin, C. G., Breyer, M., & Hartl, S. (2023) · Journal of Asthma and Allergy · doi:10.2147/jaa.s402326 · Cited by 30 · see citing works
Omalizumab for the treatment of patients with severe allergic asthma with immunoglobulin E levels above >1500 IU/mL
Menzella, F., Just, J., Sauerbeck, I. S., Mailaender, C., Saccheri, F., Thonnelier, C., Jaumont, X., & Mala, L. (2023) · World Allergy Organization Journal · doi:10.1016/j.waojou.2023.100787 · Cited by 29 · see citing works
The level of diagnostic assessment in severe asthma: A nationwide real-life study
von Bülow, A., Backer, V., Bødtger, U. C. S., Søes-Petersen, N. U., Assing, K. D., Skjold, T., & Porsbjerg, C. M. (2017) · Respiratory Medicine · doi:10.1016/j.rmed.2017.01.010 · Cited by 27 · see citing works
Allergic asthma is associated with increased risk of infections requiring antibiotics
Woehlk, C., von Bülow, A., Kriegbaum, M., Backer, V., & Porsbjerg, C. M. (2018) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2017.11.015 · Cited by 27 · see citing works
Prevalence of severe asthma according to the drug regulatory agency perspective: An Italian experience
Vianello, A., Caminati, M., Andretta, M., Menti, A. M., Tognella, S., Senna, G., & Esposti, L. D. (2019) · World Allergy Organization Journal · doi:10.1016/j.waojou.2019.100032 · Cited by 26 · see citing works
Real-life retrospective observational study to determine the prevalence and economic burden of severe asthma in Spain
Sicras‐Mainar, A., Capel, M., Navarro‐Artieda, R., Nuevo, J., Orellana, M. O., & Resler, G. (2020) · Journal of Medical Economics · doi:10.1080/13696998.2020.1719118 · Cited by 26 · see citing works
Significantly Higher Prevalence Rate of Asthma and Bipolar Disorder Co-Morbidity
Wu, M., Wang, H., Chen, Y., Lin, P., Wu, C.-K., & Tseng, P. (2016) · Medicine · doi:10.1097/md.0000000000003217 · Cited by 25 · see citing works
Asthma exacerbations: risk factors for hospital readmissions
González‐Barcala, F. J., Calvo-Álvarez, U., García-Sanz, M.-T., García-Couceiro, N., Martín‐Lancharro, P., Pose, A., Carreira, J. M., Moure-González, J.-D., Valdés, L., & Muñoz, X. (2017) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-017-1633-9 · Cited by 25 · see citing works
Clinical characteristics of the BREATHE cohort – a real-life study on patients with asthma and COPD
Backer, V., Klein, D. K., Bødtger, U. C. S., Romberg, K., Porsbjerg, C. M., Erjefalt, J. S., Kristiansen, K., Xu, R., Silberbrandt, A. W., Frøssing, L., et al. (2020) · European Clinical Respiratory Journal · doi:10.1080/20018525.2020.1736934 · Cited by 25 · see citing works
The Prevalence, Characteristics, and Patient Burden of Severe Asthma Determined by Using a Japan Health Care Claims Database
Sato, K., Ohno, T., Ishii, T., Ito, C., & Kaise, T. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.08.015 · Cited by 24 · see citing works
Prevalence and characterization of severe asthma in Hungary
Csoma, Z., Gál, Z., Gézsi, A., Herjavecz, I., & Szalai, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-66445-4 · Cited by 24 · see citing works
Tobacco Exposure and Efficacy of Biologic Therapy in Patients With Severe Asthma: A Nationwide Study From the Danish Severe Asthma Register
Soendergaard, M. B., Hansen, S., Bjerrum, A., von Bülow, A., Håkansson, K. E. J., Hilberg, O., Ingebrigtsen, T. S., Johnsen, C. R., Johansson, S. L., Rasmussen, L. M., et al. (2023) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2023.10.012 · Cited by 23 · see citing works
Long-Term Use of Short-Acting β2-Agonists in Patients With Adult-Onset Asthma
Vähätalo, I., Lehtimäki, L. A., Tuomisto, L. E., Karjalainen, J., Niemelä, O. J., Ilmarinen, P., & Kankaanranta, H. (2022) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2022.03.027 · Cited by 22 · see citing works
Can we predict who will benefit most from biologics in severe asthma? A post-hoc analysis of two phase 3 trials
Chen, W., Reddel, H. K., FitzGerald, J. M., Beasley, R. W., Janson, C., & Sadatsafavi, M. (2023) · Respiratory Research · doi:10.1186/s12931-023-02409-2 · Cited by 22 · see citing works
Severe asthma trajectories in adults: findings from the NORDSTAR cohort
von Bülow, A., Hansen, S., Sandin, P., Ernstsson, O., Janson, C., Lehtimäki, L. A., Kankaanranta, H., Ulrik, C. S., Aarli, B. B., Geale, K., et al. (2023) · European Respiratory Journal · doi:10.1183/13993003.02474-2022 · Cited by 22 · see citing works
Asthma severity, nature or nurture: genetic determinants
Raby, B. A. (2019) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000758 · Cited by 21 · see citing works
Treatable Traits as a Pathway to Remission in Asthma
Farinha, I. T., Gibson, P. G., McDonald, V. M., & Heaney, L. G. (2025) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2025.05.002 · Cited by 20 · see citing works
Picturing asthma in Turkey: results from the Turkish adult asthma registry
Çelík, G., Aydın, Ö., Gokmen, D., Buhari, G. K., Sözener, Z. Ç., Gemicioğlu, B., Bulut, İ., Beyaz, Ş., Örçen, C., Özdemir, S. K., et al. (2023) · Journal of Asthma · doi:10.1080/02770903.2023.2206902 · Cited by 20 · see citing works
Perceptions of Severe Asthma and Asthma-COPD Overlap Syndrome Among Specialists: A Questionnaire Survey
Kim, S., Moon, J., Lee, J., Ban, G., Kim, S., Kim, M., Kim, J., Kim, M., Park, C. S., Park, S., et al. (2018) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2018.10.3.225 · Cited by 20 · see citing works
Oral corticosteroid-sparing effects of mepolizumab in severe eosinophilic asthma: evidence from randomized controlled trials and real-world studies
Casale, T. B., Burnette, A. F., BOURDIN, A. A., Howarth, P. H., Hahn, B. A., Stach-Klysh, A., & Khurana, S. (2022) · Therapeutic Advances in Respiratory Disease · doi:10.1177/17534666221107313 · Cited by 18 · see citing works
Roles of real-world evidence in severe asthma treatment: challenges and opportunities
Lee, Y., Lee, J., Park, S. Y., Lee, J.-H., Kim, J., Kim, H. J., Kim, S., Chung, K. F., & Song, W. (2022) · ERJ Open Research · doi:10.1183/23120541.00248-2022 · Cited by 18 · see citing works
Characteristics of Severe Asthma Patients and Predictors of Asthma Control in the Swiss Severe Asthma Registry
Jaun, F., Tröster, L. M., Giezendanne, S., Bridevaux, P., Charbonnier, F., Clarenbach, C. F., Gianella, P., Jochmann, A., Kern, L., Miedinger, D., et al. (2023) · Respiration · doi:10.1159/000533474 · Cited by 18 · see citing works
Schistosoma mansoni antigens alter activation markers and cytokine profile in lymphocytes of patients with asthma
de Almeida, T. V. V. S., Fernandes, J. S., Lopes, D. M., Andrade, L. S., Oliveira, S. C., Carvalho, E. M., Araújo, M. I., Cruz, Á. A., & Cardoso, L. S. (2016) · Acta Tropica · doi:10.1016/j.actatropica.2016.12.002 · Cited by 16 · see citing works
Epidemiology of patients with severe asthma in Japan: a nationwide descriptive study
Kimura, Y., Suzukawa, M., Jo, T., Hashimoto, Y., Kumazawa, R., Ishimaru, M., Matsui, H., Yokoyama, A., Tanaka, G., & Yasunaga, H. (2024) · ERJ Open Research · doi:10.1183/23120541.00122-2024 · Cited by 15 · see citing works
Spontaneous sputum discriminates inflammatory phenotypes in patients with asthma
Tanaka, A., Sato, H., Akimoto, K., Matsunaga, T., & Sagara, H. (2020) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2020.06.017 · Cited by 15 · see citing works
Associations of Breathing Pattern Disorder and Nijmegen Score With Clinical Outcomes in Difficult-to-Treat Asthma
Freeman, A. T., Abraham, S., Kadalayil, L., Varkonyi-Sepp, J., Ainsworth, B., Hudson-Colby, J. J., Barber, C., Dennison, P., Azim, A., Mistry, H. M., et al. (2023) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2023.11.036 · Cited by 14 · see citing works
Severe Asthma Global Evaluation (SAGE): An Electronic Platform for Severe Asthma
Denton, E. J., Hore‐Lacy, F., Radhakrishna, N., Gilbert, A., Tay, T. R., Lee, J., Dabscheck, E. J., Harvey, E. S., Bulathsinhala, L., Fingleton, J., et al. (2019) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2019.02.042 · Cited by 14 · see citing works
Clinical characteristics of patients with not well-controlled severe asthma in Japan: Analysis of the Keio Severe Asthma Research Program in Japanese population (KEIO-SARP) registry
Tanosaki, T., Kabata, H., Matsusaka, M., Miyata, J., Masaki, K., Mochimaru, T., Okuzumi, S., Kuwae, M., Watanabe, R., Suzuki, Y., et al. (2020) · Allergology International · doi:10.1016/j.alit.2020.06.002 · Cited by 14 · see citing works
Clinical Experience with Anti-IgE Monoclonal Antibody (Omalizumab) in Pediatric Severe Allergic Asthma—A Romanian Perspective
Berghea, C. E., Bălgrădean, M., Pavelescu, C., Cirstoveanu, C. G., Toma, C., Ionescu, M. D., & Bumbăcea, R. S. (2021) · Children · doi:10.3390/children8121141 · Cited by 14 · see citing works
Disease Control, Not Severity, Drives Job Absenteeism in Young Adults with Asthma – A Nationwide Cohort Study
Håkansson, K. E. J., Backer, V., & Ulrik, C. S. (2022) · Journal of Asthma and Allergy · doi:10.2147/jaa.s360776 · Cited by 14 · see citing works
Determinants of Severe Asthma – A Long-Term Cohort Study in Northern Sweden
Bäckman, H., Stridsman, C., Hedman, L., Rönnebjerg, L., Nwaru, B. I., Sandström, T., Kankaanranta, H., Lindberg, A., & Rönmark, E. (2022) · Journal of Asthma and Allergy · doi:10.2147/jaa.s376806 · Cited by 14 · see citing works
A call to action for improving clinical outcomes in patients with asthma
McIvor, A., & Kaplan, A. G. (2020) · npj Primary Care Respiratory Medicine · doi:10.1038/s41533-020-00211-x · Cited by 14 · see citing works
Real-world treatment and health care resource use among severe asthma patients in Japan
To, Y., Taguchi, Y., Shimazaki, T., Arima, K., Yu, E., Demiya, S., & Iwanaga, T. (2021) · Respiratory Investigation · doi:10.1016/j.resinv.2021.02.010 · Cited by 14 · see citing works
Combining the Mannitol Test and FeNO in the Assessment of Poorly Controlled Asthma
Porsbjerg, C. M., Sverrild, A., & Backer, V. (2015) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2015.02.005 · Cited by 13 · see citing works
Socioeconomic status is associated with healthcare seeking behaviour and disease burden in young adults with asthma – A nationwide cohort study
Håkansson, K. E. J., Backer, V., & Ulrik, C. S. (2022) · Chronic Respiratory Disease · doi:10.1177/14799731221117297 · Cited by 12 · see citing works
T2‐low severe asthma clinical spectrum and impact: The Greek PHOLLOW cross‐sectional study
Porpodis, Κ., Zias, N., Κostikas, Κ., Τzouvelekis, Α., Makris, M. P., Konstantinou, G. Ν., Ζervas, Ε., Loukides, S., Steiropoulos, P., Κatsoulis, Κ., et al. (2025) · Clinical and Translational Allergy · doi:10.1002/clt2.70035 · Cited by 12 · see citing works
Are recreational SCUBA divers with asthma at increased risk?
Ustrup, A. S., & Ulrik, C. S. (2016) · Journal of Asthma · doi:10.1080/02770903.2016.1263861 · Cited by 12 · see citing works
Efficacy of bronchial thermoplasty in patients with severe asthma
Madsen, H., Henriksen, D. P., Backer, V., Siersted, H. C., Bjerring, N., & Ulrik, C. S. (2019) · Journal of Asthma · doi:10.1080/02770903.2019.1678636 · Cited by 12 · see citing works
The burden of severe asthma in sub-Saharan Africa: Findings from the African Severe Asthma Project
Kirenga, B., Chakaya, J. M., Yimer, G., Nyale, G. M., Haile, T., Muttamba, W., Mugenyi, L., Katagira, W., Worodria, W. O., Aanyu-Tukamuhebwa, H., et al. (2024) · Journal of Allergy and Clinical Immunology Global · doi:10.1016/j.jacig.2024.100209 · Cited by 13 · see citing works
Long-Term Clinical Remission on Benralizumab Treatment in Severe Eosinophilic Asthma: A Four-Year Real-Life Study
Quarato, C. M. I., Tondo, P., Lacedonia, D., Soccio, P., Pescatore, D., Baccellieri, M. L., Lepore, G., Barbaro, M. P. F., & Scioscia, G. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14062075 · Cited by 11 · see citing works
NORDSTAR: paving the way for a new era in asthma research
Geale, K., Darabi, H., Lindh, M., Wahl, H. F., Ström, O., Cao, H., Alvares, L., Dodge, R., Loefroth, E., Altraja, A., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.02476-2019 · Cited by 12 · see citing works
FASE-CPHG Study: identification of asthma phenotypes in the French Severe Asthma Study using cluster analysis
Rahérison, C., Parrat, É., Nocent-Eijnani, C., Mangiapan, G., Prudhomme, A., Oster, J.-P., de Vecchi, C. A., Maurer, C., Debieuvre, D., & Portel, L. (2021) · Respiratory Research · doi:10.1186/s12931-021-01723-x · Cited by 11 · see citing works
Clinical response and remission in patients treated with dupilumab for severe asthma: Results from the nationwide Danish Severe Asthma Register
Hansen, S., Håkansson, K. E. J., Soendergaard, M. B., Bjerrum, A., Schmid, J. M., Johansson, S. L., Rasmussen, L. M., Johnsen, C. R., von Bülow, A., Bonnesen, B., et al. (2025) · Respiratory Medicine · doi:10.1016/j.rmed.2025.108203 · Cited by 10 · see citing works
The Impact of Social Distancing in 2020 on Admission Rates for Exacerbations in Asthma: A Nationwide Cohort Study
Toennesen, L. L., Bonnesen, B., Sivapalan, P., Jordan, A. S., Saeed, M. I., Eklöf, J. V., Ulrik, C. S., Skaarup, K. G., Lassen, M. C. H., Biering‐Sørensen, T., et al. (2022) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2022.04.020 · Cited by 10 · see citing works
Adherence to inhaled corticosteroids in relation to quality of life and symptoms of anxiety and depression in asthma
Renzi-Lomholt, M., Håkansson, K. E. J., & Ulrik, C. S. (2022) · European Clinical Respiratory Journal · doi:10.1080/20018525.2022.2149920 · Cited by 10 · see citing works
The Danish National Database for Asthma: establishing clinical quality indicators
Hansen, S., Hoffmann‐Petersen, B., Sverrild, A., Bräuner, E. V., Lykkegaard, J., Bødtger, U. C. S., Agertoft, L., Korshoej, L., & Backer, V. (2016) · European Clinical Respiratory Journal · doi:10.3402/ecrj.v3.33903 · Cited by 10 · see citing works
BMI at school age and incident asthma admissions in early adulthood: a prospective study of 310,211 children
Ulrik, C. S., Lophaven, S., Andersen, Z. J., Sørensen, T. I. A., & Baker, J. L. (2018) · Clinical Epidemiology · doi:10.2147/clep.s156310 · Cited by 10 · see citing works
PAGE Study: Summary of a Study Protocol to Estimate the Prevalence of Severe Asthma in Spain Using Big Data Methods
Almonacid, C., Moreno, C. M., Gancedo, S. Q., Sánchez-Herrero, M. G., Gutiérrez, F. J. Á., Conejero, D. B., Cardona, V., & Soriano, J. B. (2020) · Journal of Investigational Allergology and Clinical Immunology · doi:10.18176/jiaci.0483 · Cited by 10 · see citing works

Features of severe asthma in primary care – an observational study
Telg, G., Larsson, K., Ställberg, B., Lisspers, K., Johansson, G. S., Janson, C., & Thuresson, M. (2017) · doi:10.1183/1393003.congress-2017.pa1601 · Cited by 1 · see citing works
Severe and non-severe asthma in the community: A large electronic database analysis
Varsano, S., Segev, D., & Shitrit, D. (2016) · Respiratory Medicine · doi:10.1016/j.rmed.2016.12.017 · Cited by 39 · see citing works
Severe Asthma in a General Population Study: Prevalence and Clinical Characteristics
Rönnebjerg, L., Axelsson, M., Kankaanranta, H., Bäckman, H., Rådinger, M., Lundbäck, B., & Ekerljung, L. (2021) · Journal of Asthma and Allergy · doi:10.2147/jaa.s327659 · Cited by 110 · see citing works
Prevalence and management of severe asthma in the Nordic countries: findings from the NORDSTAR cohort
Hansen, S., von Bülow, A., Sandin, P., Ernstsson, O., Janson, C., Lehtimäki, L. A., Kankaanranta, H., Ulrik, C. S., Aarli, B. B., Wahl, H. F., et al. (2023) · ERJ Open Research · doi:10.1183/23120541.00687-2022 · Cited by 40 · see citing works
Prevalence and management of severe asthma in primary care: an observational cohort study in Sweden (PACEHR)
Larsson, K., Ställberg, B., Lisspers, K., Telg, G., Johansson, G., Thuresson, M., & Janson, C. (2018) · Respiratory Research · doi:10.1186/s12931-018-0719-x · Cited by 100 · see citing works

Authors: von Bülow, A., Kriegbaum, M., Backer, V., & Porsbjerg, C.
Affiliations: University of Copenhagen (DK)
Bispebjerg Hospital (DK)
ORCID: Kriegbaum, Margit
Backer, Vibeke
Porsbjerg, Celeste
Venue: The Journal of Allergy and Clinical Immunology In Practice
Publisher: Elsevier BV
Published: 2014-11
Volume: 2
Issue: 6
Pages: 759-767.e2
ISSN: 2213-2198 (ISSN-L)
DOI: 10.1016/j.jaip.2014.05.005
OpenAlex: W2019613010
Cited by: 154
References: 50
Citations by year: 2026: 3 · 2025: 11 · 2024: 7 · 2023: 14 · 2022: 21 · 2021: 14 · 2020: 23 · 2019: 20 · 2018: 18 · 2017: 14 · 2016: 5 · 2015: 4
FWCI: 5.10
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Journal of Allergy and Clinical Immunology In Practice (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords: severe asthma, asthma prevalence, asthma control, specialist care, hospitalization, emergency department visits, adults, Denmark
MeSH terms: Adolescent, Adult, Age Factors, Ambulatory Care, Asthma, Cross-Sectional Studies, Denmark, Emergency Service, Hospital, Female, Health Resources, Hospitalization, Humans, Lung, Male, Drug Prescriptions, Referral and Consultation, Registries, Severity of Illness Index, Prevalence, Treatment Outcome, Drug Utilization Review, Anti-Asthmatic Agents, Health Care Surveys, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The prevalence of severe asthma and low asthma control among Danish adults

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks