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Cited by 118Asthma and respiratory diseasesAllergic Rhinitis and SensitizationIndoor Air Quality and Microbial Exposure

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Sensitization and Exposure to Pets: The Effect on Asthma Morbidity in the US Population

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Gergen, Peter J., Mitchell, Herman E., Calatroni, Agustin, Sever, Michelle L., Cohn, Richard D., Salo, Pӓivi M., Thorne, Peter S., Zeldin, Darryl C.·2018·The Journal of Allergy and Clinical Immunology: In Practice
DOI 10.1016/j.jaip.2017.05.019PMC PMC5756688
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Abstract

Background Although pets are found in more than 50% of US homes, the effect of pet allergen exposure on asthma morbidity in the US population is not well documented.Objective To determine the effect of dog and cat allergen exposures on asthma morbidity in the US population.Methods The National Health and Nutrition Examination Survey is a representative sample of civilian US population. Data on asthma, dog and cat allergen levels in bedroom dust, as well as specific IgE to dog and cat were analyzed for all participants 6 years or older.Results Pets are common in the United States, with more that 50% of households having a dog or a cat or both. The prevalence of allergic sensitization in the National Health and Nutrition Examination Survey population was similar for dog and cat, with both being approximately 12%. Among those who were sensitized, exposure to elevated levels of pet allergens was associated with an increased prevalence of asthma and asthma attacks. Indeed, 44.2% of the asthma attacks were attributable to exposure to high levels of dog allergen in the bedroom among patients with asthma sensitive to dog and 30.3% were attributable to cat allergen exposure among the comparable cat-sensitive and exposed group. Projecting these results to the US population indicates more than 1 million increased asthma attacks each year for the dog-sensitive and exposed group and more than 500,000 increased asthma attacks for the cat-sensitive and exposed population of patients with asthma.Conclusions Exposure to elevated levels of dog and cat allergens among those sensitized individuals with asthma is associated with excess asthma attacks. Reducing pet allergen exposures has the potential for a significant decrease in asthma morbidity.

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  1. Filep, 2012, A multi-allergen standard for the calibration of immunoassays: CREATE principles applied to eight purified allergens, Allergy, 67, 235, 10.1111/j.1398-9995.2011.02750.x · DOI

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Metadata

Authors
Gergen, P. J., Mitchell, H. E., Calatroni, A., Sever, M. L., Cohn, R. D., Salo, P. M., Thorne, P. S., & Zeldin, D. C.
Affiliations
  • National Institutes of Health (US)
  • Rho (United States) (US)
  • Social and Scientific Systems (United States) (US)
  • University of Iowa (US)
  • National Institute of Environmental Health Sciences (US)
Corresponding author
Gergen, Peter J.
ORCID
Venue
The Journal of Allergy and Clinical Immunology: In Practice
Publisher
Elsevier BV
Published
2018-01
Volume
6
Issue
1
Pages
101-107.e2
ISSN
2213-2198 (ISSN-L)
DOI
10.1016/j.jaip.2017.05.019
PMC
PMC5756688
OpenAlex
W2724616620
Cited by
117
References
20
Citations by year
2026: 9 · 2025: 19 · 2024: 14 · 2023: 15 · 2022: 12 · 2021: 8 · 2020: 13 · 2019: 18 · 2018: 8
FWCI
8.09
Type
journal article
Language
en
Open access
Licence
Locations
  • The Journal of Allergy and Clinical Immunology In Practice (acceptedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (n01ai25482-15-0-1, Z99 AI999999)
  • National Institute of Allergy and Infectious Diseases (HHSN272201000052I, N01 AI025482, UM2AI117870)
  • National Institute of Environmental Health Sciences (Z01ES025041, P30ES005605)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Keywords
pet allergens, dog allergen, cat allergen, asthma morbidity, allergen sensitization, specific IgE, asthma exacerbations, household pets, allergen exposure, NHANES
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Allergens, Animals, Asthma, Cats, Child, Dogs, Environmental Exposure, Female, Humans, Hypersensitivity, Immunization, Male, Middle Aged, Morbidity, United States, Prevalence, Air Pollution, Indoor, Young Adult, Pets

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